Intestinal absorption mechanism of tebipenem pivoxil, a novel oral carbapenem: Involvement of human OATP family in apical membrane transport

Molecular Pharmaceutics

Volumn 7, Issue 5, 2010, Pages 1747-1756

  Kato, Kazuhiko ^a   Shirasaka, Yoshiyuki ^b   Kuraoka, Erika ^b   Kikuchi, Akihiro ^c   Iguchi, Maki ^a   Suzuki, Hisashi ^a   Shibasaki, Shigeki ^a   Kurosawa, Tohru ^a   Tamai, Ikumi ^b,c  

^a MEIJI SEIKA KAISHA LTD   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

intestinal absorption; OATP1A2 and OATP2B1; oral carbapenem; Tebipenem pivoxil

Indexed keywords

ANTIBIOTIC AGENT; ASCORBIC ACID; BETA LACTAM ANTIBIOTIC; CAPTOPRIL; CARBAPENEM; CARBON 14; CEFADROXIL; CEFALEXIN; CEFCAPENE PIVOXIL; CEFDITOREN; CEFDITOREN PIVOXIL; CEFETAMET PIVOXIL; CEFIXIME; CEFPODOXIME PROXETIL; CEFTERAM PIVOXIL; CEFUROXIME AXETIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 2; PRODRUG; TEBIPENEM; TEBIPENEM PIVOXIL;

ALKALINITY; ANIMAL EXPERIMENT; APICAL MEMBRANE; ARTICLE; BACTERIAL INFECTION; CELL STRAIN CACO 2; DIFFUSION; DRUG TRANSPORT; HUMAN; HUMAN CELL; IN VIVO STUDY; INTESTINE ABSORPTION; INTESTINE MUCOSA PERMEABILITY; INTESTINE PERFUSION; ISOTOPE LABELING; MALE; MEMBRANE PERMEABILITY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RAT; RESPIRATORY TRACT INFECTION; XENOPUS;

ADMINISTRATION, ORAL; ANIMALS; ANTI-BACTERIAL AGENTS; BIOLOGICAL TRANSPORT, ACTIVE; CACO-2 CELLS; CAPTOPRIL; CARBAPENEMS; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; KINETICS; MALE; OOCYTES; ORGANIC ANION TRANSPORTERS; RATS; RATS, SPRAGUE-DAWLEY; SYMPORTERS; XENOPUS;

EID: 77957726730     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp100130b     Document Type: Article

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