Formulation development and bioavailability evaluation of a self-nanoemulsified drug delivery system of oleanolic acid

AAPS PharmSciTech

Volumn 10, Issue 1, 2009, Pages 172-182

  Xi, Jia ^a   Chang, Qi ^b   Chan, Chak K ^c   Meng, Zhao Yu ^b   Wang, Geng Nan ^b   Sun, Jia Bei ^a   Wang, Yi Tao ^a   Tong, Henry H Y ^d   Zheng, Ying ^a  

^a University of Macau   (Macao)

^b INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

^c HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^d MACAO POLYTECHNIC INSTITUTE   (Macao)

Author keywords

Bioavailability; Dissolution; Oleanolic acid; Self nanoemulsified drug delivery system (SNEDDS); Triterpenoid

Indexed keywords

CREMOPHOR; DIETHYLENE GLYCOL MONOETHYL ETHER; LABRASOL; OLEANOLIC ACID; SEFSOL 218; SURFACTANT; UNCLASSIFIED DRUG; DRUG CARRIER; DRUG DERIVATIVE; ETHYLENE GLYCOL DERIVATIVE; GLYCEROL; NANOPARTICLE; OIL; ORGANIC COMPOUND; PLANT MEDICINAL PRODUCT;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DILUTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; DRUG STABILITY; MALE; MAXIMUM PLASMA CONCENTRATION; NANOEMULSION; NONHUMAN; PARTICLE SIZE; RAT; SPRAGUE DAWLEY RAT; SUSTAINED DRUG RELEASE; TABLET FORMULATION; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; BIOAVAILABILITY; BLOOD; CHEMISTRY; COMPARATIVE STUDY; DRUG DOSAGE FORM; DRUG FORMULATION; EMULSION; EVALUATION; METHODOLOGY; ORAL DRUG ADMINISTRATION; PHARMACEUTICS; SOLUBILITY; SURFACE PROPERTY; TABLET; TRANSMISSION ELECTRON MICROSCOPY;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DOSAGE FORMS; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; EMULSIONS; ETHYLENE GLYCOLS; GLYCEROL; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; OILS; OLEANOLIC ACID; ORGANIC CHEMICALS; PLANT PREPARATIONS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SURFACE PROPERTIES; SURFACE-ACTIVE AGENTS; TABLETS; TECHNOLOGY, PHARMACEUTICAL;

EID: 67549123935     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-009-9190-9     Document Type: Article

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