Transepithelial transport of the group II metabotropic glutamate 2/3 receptor agonist (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and its prodrug (1S,2S,5R,6S)-2-[(2′S)-(2′-amino) propionyl]aminobieyclo[3.1.0]hexane-2,6-dicarboxylate (LY544344)

Drug Metabolism and Disposition

Volumn 37, Issue 1, 2009, Pages 211-220

  Varma, Manthena V S ^a,c   Eriksson, André H ^a,d   Sawada, Geri ^b   Pak, Youngeen A ^b   Perkins, Everett J ^b   Zimmerman, Cheryl L ^a,e  

^a UNIVERSITY OF MINNESOTA   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EGLUMETAD; GLYCOPROTEIN P; GLYCYLGLUTAMIC ACID; GLYCYLSARCOSINE; METABOTROPIC RECEPTOR 2 AGONIST; METABOTROPIC RECEPTOR 3 AGONIST; METABOTROPIC RECEPTOR AGONIST; PEPTIDE TRANSPORTER 1; TALAGLUMETAD; UNCLASSIFIED DRUG;

APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CELL STRAIN CACO 2; CELL TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG TRANSPORT; EPITHELIUM CELL; HUMAN; HUMAN CELL; INHIBITION KINETICS; INTESTINE ABSORPTION; INTRACELLULAR TRANSPORT; MULTIDRUG RESISTANCE; PRIORITY JOURNAL;

EID: 58149469249     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.022012     Document Type: Article

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