Polychlorinated biphenyls, organochlorine pesticides and neurodevelopment

Current Opinion in Pediatrics

Volumn 20, Issue 2, 2008, Pages 198-204

  Korrick, Susan A ^a,b,c   Sagiv, Sharon K ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c CHANNING LABORATORY   (United States)

Author keywords

Neurodevelopment; Organochlorines; Pesticides; Polychlorinated biphenyls

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHANE; CHLORPHENOTANE; HEXACHLOROBENZENE; POLYCHLORINATED BIPHENYL;

BEHAVIOR DISORDER; COGNITION; HUMAN; IMPULSE CONTROL DISORDER; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; REVIEW;

CHILD; CHILD BEHAVIOR DISORDERS; COHORT STUDIES; DEVELOPMENTAL DISABILITIES; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; FEMALE; HEXACHLOROBENZENE; HUMANS; NEUROPSYCHOLOGICAL TESTS; PESTICIDES; POLYCHLORINATED BIPHENYLS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROSPECTIVE STUDIES;

EID: 40549085322     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOP.0b013e3282f6a4e9     Document Type: Review

References (85)

1. Jacobson JL, Jacobson SW. Developmental effects of PCBs in fish eater cohort studies. In: Robertson LW, Hansen LG, editors. PCBs: recent advances in environmental toxicology and health effects. Lexington: University Press of Kentucky; 2001. pp. 127-136.
2. Korrick SA. Polychlorinated biphenyls (PCBs) and neurodevelopment in general population samples. In: Robertson LW, Hansen LG, editors. PCBs: recent advances in environmental toxicology and health effects. Lexington: University Press of Kentucky; 2001. pp. 143-154.
3. Longnecker MP, Korrick SA, Moysich KB. Human health effects of polychlorinated biphenyls. In: Schecter A, Gasiewicz TA, editors. Dioxins and health, 2nd ed Hoboken: Wiley; 2003. pp. 679-728.
4. Longnecker MP, Rogan WJ, Lucier G. The human health effects of DDT (dichlorodiphenyltrichloroethane) and PCBS (polychlorinated biphenyls) and an overview of organochlorines in public health. Annu Rev Public Health 1997; 18:211-244.
5. Schantz SL, Widholm JJ, Rice DC. Effects of PCB exposure on neuropsychological function in children. Environ Health Perspect 2003; 111:357-576.
6. Schantz SL. Developmental neurotoxicity of PCBs in humans: what do we know and where do we go from here? Neurotoxicol Teratol 1996; 18:217-227; discussion 229-276.
7. Glynn A, Aune M, Darnerud PO, et al. Determinants of serum concentrations of organochlorine compounds in Swedish pregnant women: a cross-sectional study. Environ Health 2007; 6:2.
8. Patandin S, Dagnelie PC, Mulder PG, et al. Dietary exposure to polychlorinated biphenyls and dioxins from infancy until adulthood: a comparison between breast-feeding, toddler, and long-term exposure. Environ Health Perspect 1999; 107:45-51.
9. Jamshidi A, Hunter S, Hazrati S, Harrad S. Concentrations and chiral signatures of polychlorinated biphenyls in outdoor and indoor air and soil in a major UK conurbation. Environ Sci Technol 2007; 41:2153-2158.
10. Loffler G, Van Bavel B. Potential pathways and exposure to explain the human body burden of organochlorine compounds: a multivariate statistical analysis of human monitoring in Wurzburg, Germany. Chemosphere 2000; 40:1075-1082.
11. Herrick RF, McClean MD, Meeker JD, et al. An unrecognized source of PCB contamination in schools and other buildings. Environ Health Perspect 2004; 112:1051-1053.
12. Hites RA, Foran JA, Carpenter DO, et al. Global assessment of organic contaminants in farmed salmon. Science 2004; 303:226-229.
13. Rogan WJ. PCBs and cola-colored babies: Japan, 1968, and Taiwan, 1979. Teratology 1982; 26:259-261.
14. Rogan WJ, Gladen BC, Hung KL, et al. Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan. Science 1988; 241:334-336.
15. Yamashita F, Hayashi M. Fetal PCB syndrome: clinical features, intrauterine growth retardation and possible alteration in calcium metabolism. Environ Health Perspect 1985; 59:41-45.
16. Yoshimura T, Ikeda M. Growth of school children with polychlorinated biphenyl poisoning or yusho. Environ Res 1978; 17:416-425.
17. Yu ML, Hsu CC, Gladen BC, Rogan WJ. In utero PCB/PCDF exposure: relation of developmental delay to dysmorphology and dose. Neurotoxicol Teratol 1991; 13:195-202.
18. Chen YC, Guo YL, Hsu CC. Cognitive development of children prenatally exposed to polychlorinated biphenyls (Yu-Cheng children) and their siblings. J Formos Med Assoc 1992; 91:704-707.
19. Chen YC, Guo YL, Hsu CC, Rogan WJ. Cognitive development of Yu-Cheng ('oil disease') children prenatally exposed to heat-degraded PCBs. JAMA 1992; 268:3213-3218.
20. Chen YC, Yu ML, Rogan WJ, et al. A 6-year follow-up of behavior and activity disorders in the Taiwan Yu-cheng children. Am J Public Health 1994; 84:415-421.
21. Guo YL, Lin CJ, Yao WJ, et al. Musculoskeletal changes in children prenatally exposed to polychlorinated biphenyls and related compounds (Yu-Cheng children). J Toxicol Environ Health 1994; 41:83-93.
22. Kunita N, Kashimoto T, Miyata H, et al. Causal agents of yusho. Prog Clin Biol Res 1984; 137:45-58.
23. Rogan WJ, Gladen BC, McKinney JD, et al. Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in human milk: effects of maternal factors and previous lactation. Am J Public Health 1986; 76: 172-177.
24. Rogan WJ, Gladen BC, McKinney JD, et al. Neonatal effects of transplacental exposure to PCBs and DDE. J Pediatr 1986; 109:335-341.
25. Gladen BC, Rogan WJ, Hardy P, et al. Development after exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene transplacentally and through human milk. J Pediatr 1988; 113:991-995.
26. Rogan WJ, Gladen BC. PCBs, DDE, and child development at 18 and 24 months. Ann Epidemiol 1991; 1:407-413.
27. Gladen BC, Rogan WJ. Effects of perinatal polychlorinated biphenyls and dichlorodiphenyl dichloroethene on later development. J Pediatr 1991;119:58-63.
28. Schwartz PM, Jacobson SW, Fein G, et al. Lake Michigan fish consumption as a source of polychlorinated biphenyls in human cord serum, maternal serum, and milk. Am J Public Health 1983; 73:293-296.
29. Jacobson JL, Jacobson SW. The effects of perinatal exposure to polychlorinated biphenyls and related contaminants. In: Needleman HL, Bellinger D, editors. Prenatal exposure to toxicants: developmental consequences. Baltimore: Johns Hopkins University Press; 1994:130-147.
30. Jacobson JL, Jacobson SW, Schwartz PM, et al. Prenatal exposure to an environmental toxin: a test of the multiple effects model. Dev Psychol 1984;20:523-532.
31. Jacobson SW, Fein GG, Jacobson JL, et al. The effect of intrauterine PCB exposure on visual recognition memory. Child Dev 1985; 56:853-860.
32. Jacobson JL, Jacobson SW. Evidence for PCBs as neurodevelopmental toxicants in humans. Neurotoxicology 1997; 18:415-424.
33. Jacobson JL, Jacobson SW, Humphrey HE. Effects of in utero exposure to polychlorinated biphenyls and related contaminants on cognitive functioning in young children. J Pediatr 1990; 116:38-45.
34. Jacobson JL, Jacobson SW. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med 1996; 335:783-789.
35. Jacobson JL, Jacobson SW. Prenatal exposure to polychlorinated biphenyls and attention at school age. J Pediatr 2003; 143:780-788.
36. Jacobson JL, Jacobson SW, Padgett RJ, et al. Effects of prenatal PCB exposure on cognitive processing efficiency and sustained attention. Dev Psychol 1992; 28:297-306.
37. Steuerwald U, Weihe P, Jorgensen PJ, et al. Maternal seafood diet, methylmercury exposure, and neonatal neurologic function. J Pediatr 2000; 136:599-605.
38. Grandjean P, Weihe P, Needham LL, et al. Relation of a seafood diet to mercury, selenium, arsenic, and polychlorinated biphenyl and other organochlorine concentrations in human milk. Environ Res 1995; 71:29-38.
39. Longnecker MP, Wolff MS, Gladen BC, et al. Comparison of polychlorinated biphenyl levels across studies of human neurodevelopment. Environ Health Perspect 2003; 111:65-70.
40. Dahl R, White RF, Weihe P, et al. Feasibility and validity of three computer-assisted neurobehavioral tests in 7-year-old children. Neurotoxicol Teratol 1996; 18:413-419.
41. Grandjean P, Weihe P, Burse VW, et al. Neurobehavioral deficits associated with PCB in 7-year-old children prenatally exposed to seafood neurotoxicants. Neurotoxicol Teratol 2001; 23:305-317.
42. Huisman M, Koopman-Esseboom C, Fidler V, et al. Perinatal exposure to polychlorinated biphenyls and dioxins and its effect on neonatal neurological development. Early Hum Dev 1995; 41:111-127.
43. Koopman-Esseboom C, Weisglas-Kuperus N, De Ridder MA, et al. Effects of polychlorinated biphenyl/dioxin exposure and feeding type on infants' mental and psychomotor development. Pediatrics 1996; 97:700-706.
44. Patandin S, Lanting CI, Mulder PG, et al. Effects of environmental exposure to polychlorinated biphenyls and dioxins on cognitive abilities in Dutch children at 42 months of age. J Pediatr 1999; 134:33-41.
45. Vreugdenhil HJI, Lanting CI, Mulder PGH, et al. Effects of prenatal PCB and dioxin background exposure on cognitive and motor abilities in Dutch children at school age. J Pediatr 2002; 140:48-56.
46. Vreugdenhil HJ, Mulder PG, Emmen HH, Weisglas-Kuperus N. Effects of perinatal exposure to PCBs on neuropsychological functions in the Rotterdam cohort at 9 years of age. Neuropsychology 2004; 18:185-193.
47. Vreugdenhil HJ, Van Zanten GA, Brocaar MP, et al. Prenatal exposure to polychlorinated biphenyls and breastfeeding: opposing effects on auditory P300 latencies in 9-year-old Dutch children. Dev Med Child Neurol 2004; 46:398-405.
48. Lonky E, Reihman J, Darvill T, et al. Neonatal behavioral assessment scale performance in humans influenced by maternal consumption of environmentally contaminated Lake Ontario fish. J Great Lakes Res 1996; 22:198-212.
49. Stewart P, Reihman J, Lonky E, et al. Prenatal PCB exposure and neonatal behavioral assessment scale (NBAS) performance. Neurotoxicol Teratol 2000; 22:21-29.
50. Darvill T, Lonky E, Reihman J, et al. Prenatal exposure to PCBs and infant performance on the Fagan test of infant intelligence. Neurotoxicology 2000; 21:1029-1038.
51. Stewart PW, Reihman J, Lonky EI, et al. Cognitive development in preschool children prenatally exposed to PCBs and MeHg. Neurotoxicol Teratol 2003; 25:11-22.
52. Stewart P, Fitzgerald S, Reihman J, et al. Prenatal PCB exposure, the corpus callosum, and response inhibition. Environ Health Perspect 2003; 111:1670-1677.
53. Stewart P, Reihman J, Gump B, et al. Response inhibition at 8 and 9 1/2 years of age in children prenatally exposed to PCBs. Neurotoxicol Teratol 2005; 27:771-780. This study found strong associations of prenatal PCB exposure with behavior (attention and response inhibition) in New York children born to mothers who ate contaminated Great Lakes fish. This is an important corroboration of similar findings in Michigan infants (Lake Michigan fish eaters' children) and, more importantly, underscores the likely sensitivity of child behavior to early life PCB exposures.
54. Stewart PW, Sargent DM, Reihman J, et al. Response inhibition during differential reinforcement of low rates (DRL) schedules may be sensitive to low-level polychlorinated biphenyl, methylmercury, and lead exposure in children. Environ Health Perspect 2006; 114:1923-1929.
55. Winneke G, Bucholski A, Heinzow B, et al. Developmental neurotoxicity of polychlorinated biphenyls (PCBS): cognitive and psychomotor functions in 7-month old children. Toxicol Lett 1998; 102-103:423-428.
56. Walkowiak J, Wiener JA, Fastabend A, et al. Environmental exposure to polychlorinated biphenyls and quality of the home environment: effects on psychodevelopment in early childhood. Lancet 2001; 358:1602-1607.
57. Dallaire F, Dewailly E, Muckle G, et al. Acute infections and environmental exposure to organochlorines in Inuit infants from Nunavik. Environ Health Perspect 2004; 112:1359-1365.
58. Despres C, Beuter A, Richer F, et al. Neuromotor functions in Inuit preschool children exposed to Pb, PCBs, and Hg. Neurotoxicol Teratol 2005; 27:245-257.
59. Muckle G, Ayotte P, Dewailly EE, et al. Prenatal exposure of the northern Quebec Inuit infants to environmental contaminants. Environ Health Perspect 2001; 109:1291-1299.
60. Saint-Amour D, Roy MS, Bastien C, et al. Alterations of visual evoked potentials in preschool Inuit children exposed to methylmercury and polychlorinated biphenyls from a marine diet. Neurotoxicology 2006; 27:567-578.
61. Daniels JL, Longnecker MP, Klebanoff MA, et al. Prenatal exposure to lowl-evel polychlorinated biphenyls in relation to mental and motor development at 8 months. Am J Epidemiol 2003; 157:485-492.
62. Gray KA, Klebanoff MA, Brock JW, et al. In utero exposure to background levels of polychlorinated biphenyls and cognitive functioning among school-age children. Am J Epidemiol 2005; 162:17-26. This analysis did not find associations of IQ at ages 4 or 7 with prenatal PCB exposure among a large sample of Collaborative Perinatal Project infants. Thus, the study did not confirm findings in the other major published study of IQ among Michigan 11-year-olds and adds to uncertainty regarding the relation of PCBs with childhood IQ. An apparent association of PCBs with higher IQ at age 4 years also identified the potential for residual confounding to affect PCB analyses. For example, in contrast to much of the childhood lead exposure literature, PCB exposure is associated with sociodemographic advantage in some populations and thus residual confounding by these factors may attenuate associations.
63. Sala M, Ribas-Fito N, Cardo E, et al. Levels of hexachlorobenzene and other organochlorine compounds in cord blood: exposure across placenta. Chemosphere 2001; 43:895-901.
64. Ribas-Fito N, Cardo E, Sala M, et al. Breastfeeding, exposure to organochlorine compounds, and neurodevelopment in infants. Pediatrics 2003; 111:e580-e585.
65. Ribas-Fito N, Torrent M, Carrizo D, et al. In utero exposure to background concentrations of DDT and cognitive functioning among preschoolers. Am J Epidemiol 2006; 164:955-962.
66. Ribas-Fito N, Torrent M, Carrizo D, et al. Exposure to hexachlorobenzene during pregnancy and children's social behavior at 4 years of age. Environ Health Perspect 2007; 115:447-450. This is an important example of a relatively new study focused on HCB exposures, an area for which there has been limited prior human research. The finding of behavioral associations, particularly social competence and ADHD symptoms, with prenatal HCB exposure is an association for which further study is merited and which confirms the potential sensitivity of child behavior to early life organochlorine exposure.
67. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington: American Psychiatric Association; 2000.
68. Engel SM, Berkowitz GS, Barr DB, et al. Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort. Am J Epidemiol 2007; 165:1397-1404.
69. Fenster L, Eskenazi B, Anderson M, et al. In utero exposure to DDT and performance on the Brazelton neonatal behavioral assessment scale. Neurotoxicology 2007; 28:471-477.
70. Eskenazi B, Marks AR, Bradman A, et al. In utero exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) and neurodevelopment among young Mexican American children. Pediatrics 2006; 118:233-241.
71. Torres-Sanchez L, Rothenberg SJ, Schnaas L, et al. In utero p,p′-DDE exposure and infant neurodevelopment: a perinatal cohort in Mexico. Environ Health Perspect 2007; 115:435-439.
72. Nakajima S, Saijo Y, Kato S, et al. Effects of prenatal exposure to polychlorinated biphenyls and dioxins on mental and motor development in Japanese children at 6 months of age. Environ Health Perspect 2006; 114:773-778.
73. Rice DC. Neurotoxicity produced by developmental exposure to PCBs. Ment Retard Dev Disabil Res Rev 1997; 3:223-229.
74. Budtz-Jorgensen E, Keiding N, Grandjean P, White RF. Methylmercury neurotoxicity independent of PCB exposure. Environ Health Perspect 1999; 107:A236-A237.
75. Grandjean P, Weihe P, White RF, et al. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol 1997; 19:417-428.
76. Bellinger DC. What is an adverse effect? A possible resolution of clinical and epidemiological perspectives on neurobehavioral toxicity. Environ Res 2004; 95:394-405.
77. Korrick SA, Bellinger DC. Invited commentary: persistent organic pollutants and childhood learning and behavioural disorders. J Epidemiol Community Health 2007; 61:564-565.
78. Bellinger DC. Interpretation of small effect sizes in occupational and environmental neurotoxicology: individual versus population risk. Neurotoxicology 2007; 28:245-251.
79. Integrated Risk Information System. Hexachlorobenzene (CASRN 118-74-1). Washington: National Center for Environmental Assessment, US Environmental Protection Agency; 1996.
80. Integrated Risk Information System. p,p′- Dichlorodiphenyltrichloroethane (DDT) (CASRN 50-29-3). Washington: National Center for Environmental Assessment, US Environmental Protection Agency; 1996.
81. Integrated Risk Information System. Polychlorinated biphenyls (PCBs) (CASRN 1336-36-3). Washington: National Center for Environmental Assessment, US Environmental Protection Agency; 1997.
82. Laden F, Neas LM, Spiegelman D, et al. Predictors of plasma concentrations of DDE and PCBs in a group of US women. Environ Health Perspect 1999; 107:75-81.
83. Choi AL, Levy JI, Dockery DW, et al. Does living near a Superfund site contribute to higher polychlorinated biphenyl (PCB) exposure? Environ Health Perspect 2006; 114:1092-1098. This assessment of predictors of exposure among infants whose mothers lived adjacent to a PCB-contaminated Superfund site supports the notion that PCB exposure risk factors are variable and include not just diet, but a variety of sociodemographic characteristics as well as important local and/or regional factors.
84. Cohen JT, Bellinger DC, Connor WE, Shaywitz BA. A quantitative analysis of prenatal intake of n-3 polyunsaturated fatty acids and cognitive development. Am J Prev Med 2005; 29:366-374.
85. Nesheim MC, Yakatine AL, editors. Seafood choices: balancing benefits and risks. Washington: National Academies Press; 2007.