Hydroxylation increases the neurotoxic potential of BDE-47 to affect exocytosis and calcium homeostasis in PC12 cells

Environmental Health Perspectives

Volumn 116, Issue 5, 2008, Pages 637-643

  Dingemans, Milou M L ^a   de Groot, Aart ^a   van Kleef, Regina G D M ^a   Bergman, Åke ^b   van den Berg, Martin ^a   Vijverberg, Henk P M ^a   Westerink, Remco H S ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Bioactivation; Brominated flame retardants; Calcium; Catecholamine; Exocytosis; Intracellular calcium stores; Neurotoxicity; Neurotransmitter release; Persistent organic pollutants; Polybrominated diphenyl ether

Indexed keywords

2,2',4,4' TETRABROMODIPHENYL ETHER; 6 HYDROXY 2,2',4,4' TETRABROMODIPHENYL ETHER; CALCIUM; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CATECHOLAMINE; FLAME RETARDANT; FURA 2; POLYBROMINATED DIPHENYL ETHER; THAPSIGARGIN;

AEROBIC METABOLISM; AMPEROMETRY; ANIMAL CELL; ARTICLE; BRAIN MITOCHONDRION; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL STRAIN; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENVIRONMENTAL EXPOSURE; EXOCYTOSIS; FLUORESCENCE ANALYSIS; HYDROXYLATION; NEUROTOXICITY; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; TOXICITY TESTING;

ANIMALS; CALCIUM; CATECHOLAMINES; ENVIRONMENTAL EXPOSURE; EXOCYTOSIS; FLAME RETARDANTS; HOMEOSTASIS; HYDROXYLATION; PC12 CELLS; POLYBROMINATED BIPHENYLS; RATS;

EID: 45749122700     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.11059     Document Type: Article

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