Gene transfer of a synthetic pacemaker channel into the heart: A novel strategy for biological pacing

Circulation

Volumn 114, Issue 16, 2006, Pages 1682-1686

  Kashiwakura, Yuji ^a   Cho, Hee Cheol ^a   Barth, Andreas S ^a   Azene, Ezana ^a   Marbán, Eduardo ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Gene therapy; Ion channels; Pacing

Indexed keywords

POTASSIUM CHANNEL;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ARTIFICIAL HEART PACEMAKER; CONTROLLED STUDY; ELECTROCARDIOGRAM; FEMALE; GENE TRANSFER; HEART DEPOLARIZATION; HEART MUSCLE; HEART VENTRICLE; HYPERPOLARIZATION; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS;

ANIMALS; BIOLOGICAL CLOCKS; CELL LINE; FEMALE; GENE TRANSFER TECHNIQUES; GUINEA PIGS; HEART; HUMANS; ION CHANNEL GATING; ION CHANNELS; KV1.4 POTASSIUM CHANNEL; MYOCYTES, CARDIAC;

EID: 33750203720     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.106.634865     Document Type: Article

References (20)

1. DiFrancesco D. The onset and autonomic regulation of cardiac pacemaker activity: relevance of the f current. Cardiovasc Res. 1995;29:449-456.
2. Qu J, Plotnikov AN, Danilo P Jr, Shlapakova I, Cohen IS, Robinson RB, Rosen MR. Expression and function of a biological pacemaker in canine heart. Circulation. 2003;107:1106-1109.
3. Plotnikov AN, Sosunov EA, Qu J, Shlapakova IN, Anyukhovsky EP, Liu L, Janse MJ, Brink PR, Cohen IS, Robinson RB, Danilo P Jr, Rosen MR. Biological pacemaker implanted in canine left bundle branch provides ventricular escape rhythms that have physiologically acceptable rates. Circulation. 2004;109:506-512.
4. Potapova I, Plotnikov A, Lu Z, Danilo P Jr, Valiunas V, Qu J, Doronin S, Zuckerman J, Shlapakova IN, Gao J, Pan Z, Herron AJ, Robinson RB, Brink PR, Rosen MR, Cohen IS. Human mesenchymal stem cells as a gene delivery system to create cardiac pacemakers. Circ Res. 2004;94:952-959.
5. Ulens C, Tytgat J. Functional heteromerization of HCN1 and HCN2 pacemaker channels. J Biol Chem. 2001;276:6069-6072.
6. Brewster AL, Bernard JA, Gall CM, Baram TZ. Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures. Neurobiol Dis. 2005;19:200-207.
7. Cerbai E, Pino R, Porciatti F, Sani G, Toscano M, Maccherini M, Giunti G, Mugelli A. Characterization of the hyperpolarization-activated current, if, in ventricular myocytes from human failing heart. Circulation. 1997;95:568-571.
8. Hoppe UC, Jansen E, Sudkamp M, Beuckelmann DJ. Hyperpolarization- activated inward current in ventricular myocytes from normal and failing human hearts. Circulation. 1998;97:55-65.
9. Hardy S, Kitamura M, Harris-Stansil T, Dai Y, Phipps M. Construction of adenovirus vectors through Cre-lox recombination. J Virol. 1997;71:1842-1849.
10. Hamill OP MA, Neher E, Sakmann B, Sigworth FJ. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 1981;391:85-100.
11. Miake J, Marban E, Nuss HB. Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominant-negative suppression. J Clin Invest. 2003;111:1529-1536.
12. Mitra RMM. Two types of calcium channels in guinea pig ventricular myocytes. Proc Natl Acad Sci U S A. 1986;83:5340-5344.
13. Ennis IL, Li RA, Murphy AM, Marban E, Nuss HB. Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility. J Clin Invest. 2002;109:393-400.
14. Heginbotham LMR. Conduction properties of the cloned Shaker K+ channel. Biophys J. 1993;65:2089-2096.
15. Miller AG, Aldrich RW. Conversion of a delayed rectifier K+ channel to a voltage-gated inward rectifier K+ channel by three amino acid substitutions. Neuron. 1996;16:853-858.
16. Wilson CJ. The mechanism of intrinsic amplification of hyperpolarizations and spontaneous bursting in striatal cholinergic interneurons. Neuron. 2005;45:575-585.
17. Xue T, Marban E, Li RA. Dominant-negative suppression of HCN1- and HCN2-encoded pacemaker currents by an engineered HCN1 construct: insights into structure-function relationships and multimerization. Circ Res. 2002;90:1267-1273.
18. Deans RJ, Moseley AB. Mesenchymal stem cells: biology and potential clinical uses. Exp Hematol. 2000;28:875-884.
19. Mays DJ, Foose JM, Philipson LH, Tamkun MM. Localization of the Kv1.5 K+ channel protein in explanted cardiac tissue. J Clin Invest. 1995;96:282-292.
20. Barry DM, Trimmer JS, Merlie JP, Nerbonne JM. Differential expression of voltage-gated K+ channel subunits in adult rat heart: relation to functional K channels? Circ Res. 1995;77:361-369.