메뉴 건너뛰기




Volumn 23, Issue 1, 2008, Pages 46-54

Biological pacemakers as a therapy for cardiac arrhythmias

Author keywords

Arrhythmia; Biological pacemakers; Gene and cell therapy

Indexed keywords

CELL FUSION; EMBRYONIC STEM CELL; GENE REPRESSION; GENE TRANSFER; HEART ARRHYTHMIA; HEART PACING; HEART RHYTHM; PACEMAKER; PRIORITY JOURNAL; REVIEW; SOMATIC CELL; STEM CELL TRANSPLANTATION;

EID: 40349092932     PISSN: 02684705     EISSN: None     Source Type: Journal    
DOI: 10.1097/HCO.0b013e3282f30416     Document Type: Review
Times cited : (22)

References (67)
  • 2
    • 33644849222 scopus 로고    scopus 로고
    • Heart disease and stroke statistics: 2006 update. A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • Thom T, Haase N, Rosamond W, et al. Heart disease and stroke statistics: 2006 update. A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2006; 113: e85-e151.
    • (2006) Circulation , vol.113
    • Thom, T.1    Haase, N.2    Rosamond, W.3
  • 3
    • 0025542167 scopus 로고
    • Efficacy and safety of quinidine therapy for maintenance of sinus rhythm after cardioversion. A meta-analysis of randomized control trials
    • Coplen SE, Antman EM, Berlin JA, et al. Efficacy and safety of quinidine therapy for maintenance of sinus rhythm after cardioversion. A meta-analysis of randomized control trials. Circulation 1990; 82:1106-1116.
    • (1990) Circulation , vol.82 , pp. 1106-1116
    • Coplen, S.E.1    Antman, E.M.2    Berlin, J.A.3
  • 4
    • 0026011647 scopus 로고
    • Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial
    • Echt DS, Liebson PR, Mitchell LB, et al. Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial. N Engl J Med 1991; 324:781-788.
    • (1991) N Engl J Med , vol.324 , pp. 781-788
    • Echt, D.S.1    Liebson, P.R.2    Mitchell, L.B.3
  • 5
    • 0027380237 scopus 로고
    • Preliminary results of the Cardiac Arrest Study Hamburg (CASH). CASH Investigators
    • Siebels J, Cappato R, Ruppel R, et al. Preliminary results of the Cardiac Arrest Study Hamburg (CASH). CASH Investigators. Am J Cardiol 1993; 72:109F-113F.
    • (1993) Am J Cardiol , vol.72
    • Siebels, J.1    Cappato, R.2    Ruppel, R.3
  • 6
    • 8944234858 scopus 로고    scopus 로고
    • Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol
    • Waldo AL, Camm AJ, deRuyter H, et al. Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol. Lancet 1996; 348:7-12.
    • (1996) Lancet , vol.348 , pp. 7-12
    • Waldo, A.L.1    Camm, A.J.2    deRuyter, H.3
  • 7
    • 0033156750 scopus 로고    scopus 로고
    • Ablation of ventricular tachycardia in the setting of coronary artery disease
    • Richardson AW, Josephson ME. Ablation of ventricular tachycardia in the setting of coronary artery disease. Curr Cardiol Rep 1999; 1:157-164.
    • (1999) Curr Cardiol Rep , vol.1 , pp. 157-164
    • Richardson, A.W.1    Josephson, M.E.2
  • 8
    • 0035810152 scopus 로고    scopus 로고
    • Atrial fibrillation
    • Falk RH. Atrial fibrillation. N Engl J Med 2001; 344:1067-1078.
    • (2001) N Engl J Med , vol.344 , pp. 1067-1078
    • Falk, R.H.1
  • 10
    • 0035002427 scopus 로고    scopus 로고
    • Survey of cardiac pacing and implanted defibrillator practice patterns in the United States in 1997
    • Bernstein AD, Parsonnet V. Survey of cardiac pacing and implanted defibrillator practice patterns in the United States in 1997. Pacing Clin Electrophysiol 2001; 24:842-855.
    • (2001) Pacing Clin Electrophysiol , vol.24 , pp. 842-855
    • Bernstein, A.D.1    Parsonnet, V.2
  • 11
    • 0027403280 scopus 로고
    • Primary structure and functional expression of a mouse inward rectifier potassium channel
    • Kubo Y, Baldwin TJ, Jan YN, Jan LY. Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature 1993; 362:127-133.
    • (1993) Nature , vol.362 , pp. 127-133
    • Kubo, Y.1    Baldwin, T.J.2    Jan, Y.N.3    Jan, L.Y.4
  • 12
    • 0030606298 scopus 로고    scopus 로고
    • Regions responsible for the assembly of inwardly rectifying potassium channels
    • Tinker A, Jan YN, Jan LY. Regions responsible for the assembly of inwardly rectifying potassium channels. Cell 1996; 87:857-868.
    • (1996) Cell , vol.87 , pp. 857-868
    • Tinker, A.1    Jan, Y.N.2    Jan, L.Y.3
  • 13
    • 0037068468 scopus 로고    scopus 로고
    • Biological pacemaker created by gene transfer
    • Miake J, Marban E, Nuss HB. Biological pacemaker created by gene transfer. Nature 2002; 419:132-133.
    • (2002) Nature , vol.419 , pp. 132-133
    • Miake, J.1    Marban, E.2    Nuss, H.B.3
  • 14
    • 0027509511 scopus 로고
    • Cardiac pacemaking in the sinoatrial node
    • Irisawa H, Brown HF, Giles W. Cardiac pacemaking in the sinoatrial node. Physiol Rev 1993; 73:197-227.
    • (1993) Physiol Rev , vol.73 , pp. 197-227
    • Irisawa, H.1    Brown, H.F.2    Giles, W.3
  • 16
    • 23844444042 scopus 로고    scopus 로고
    • Characterization and culture of human embryonic stem cells
    • Hoffman LM, Carpenter MK. Characterization and culture of human embryonic stem cells. Nat Biotechnol 2005; 23:699-708.
    • (2005) Nat Biotechnol , vol.23 , pp. 699-708
    • Hoffman, L.M.1    Carpenter, M.K.2
  • 17
    • 0037144701 scopus 로고    scopus 로고
    • Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells
    • Xu C, Police S, Rao N, Carpenter MK. Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells. Circ Res 2002; 91:501-508.
    • (2002) Circ Res , vol.91 , pp. 501-508
    • Xu, C.1    Police, S.2    Rao, N.3    Carpenter, M.K.4
  • 18
    • 0034904645 scopus 로고    scopus 로고
    • Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes
    • Kehat I, Kenyagin-Karsenti D, Snir M, et al. Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J Clin Invest 2001; 108:407-414.
    • (2001) J Clin Invest , vol.108 , pp. 407-414
    • Kehat, I.1    Kenyagin-Karsenti, D.2    Snir, M.3
  • 19
    • 0038300672 scopus 로고    scopus 로고
    • Human embryonic stem cells develop into multiple types of cardiac myocytes: Action potential characterization
    • He JQ, Ma Y, Lee Y, et al. Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization. Circ Res 2003; 93:32-39.
    • (2003) Circ Res , vol.93 , pp. 32-39
    • He, J.Q.1    Ma, Y.2    Lee, Y.3
  • 20
    • 0038210217 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells to cardiomyocytes: Role of coculture with visceral endoderm-like cells
    • Mummery C, Ward-van Oostwaard D, Doevendans P, et al. Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells. Circulation 2003; 107:2733-2740.
    • (2003) Circulation , vol.107 , pp. 2733-2740
    • Mummery, C.1    Ward-van Oostwaard, D.2    Doevendans, P.3
  • 21
    • 5044221669 scopus 로고    scopus 로고
    • Electromechanical integration of cardiomyocytes derived from human embryonic stem cells
    • Kehat I, Khimovich L, Caspi O, et al. Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. Nat Biotechnol 2004; 22:1282-1289.
    • (2004) Nat Biotechnol , vol.22 , pp. 1282-1289
    • Kehat, I.1    Khimovich, L.2    Caspi, O.3
  • 22
    • 11244249952 scopus 로고    scopus 로고
    • Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: Insights into the development of cell-based pacemakers
    • Xue T, Cho HC, Akar FG, et al. Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers. Circulation 2005; 111:11-20.
    • (2005) Circulation , vol.111 , pp. 11-20
    • Xue, T.1    Cho, H.C.2    Akar, F.G.3
  • 23
    • 0001683386 scopus 로고
    • Propagation of action potentials and the structure of the nexus in cardiac muscle
    • Barr L, Dewey MM, Berger W. Propagation of action potentials and the structure of the nexus in cardiac muscle. J Gen Physiol 1965; 48:797-823.
    • (1965) J Gen Physiol , vol.48 , pp. 797-823
    • Barr, L.1    Dewey, M.M.2    Berger, W.3
  • 24
    • 0019624299 scopus 로고
    • Junctional intercellular communication: The cell-to-cell membrane channel
    • Loewenstein WR. Junctional intercellular communication: the cell-to-cell membrane channel. Physiol Rev 1981; 61:829-913.
    • (1981) Physiol Rev , vol.61 , pp. 829-913
    • Loewenstein, W.R.1
  • 25
    • 0024393572 scopus 로고
    • Electrical uncoupling and impulse propagation in isolated sheep Purkinje fibers
    • Jalife J, Sicouri S, Delmar M, Michaels DC. Electrical uncoupling and impulse propagation in isolated sheep Purkinje fibers. Am J Physiol 1989; 257:H179-H189.
    • (1989) Am J Physiol , vol.257
    • Jalife, J.1    Sicouri, S.2    Delmar, M.3    Michaels, D.C.4
  • 26
    • 0037195733 scopus 로고    scopus 로고
    • An electric field mechanism for transmission of excitation between myocardial cells
    • Sperelakis N. An electric field mechanism for transmission of excitation between myocardial cells. Circ Res 2002; 91:985-987.
    • (2002) Circ Res , vol.91 , pp. 985-987
    • Sperelakis, N.1
  • 27
    • 0037458671 scopus 로고    scopus 로고
    • Cyclic variation of intracellular calcium: A critical factor for cardiac pacemaker cell dominance
    • Lakatta EG, Maltsev VA, Bogdanov KY, et al. Cyclic variation of intracellular calcium: a critical factor for cardiac pacemaker cell dominance. Circ Res 2003; 92:e45-e50.
    • (2003) Circ Res , vol.92
    • Lakatta, E.G.1    Maltsev, V.A.2    Bogdanov, K.Y.3
  • 28
    • 0012457490 scopus 로고    scopus 로고
    • Hyperpolarization-activated cation currents: From molecules to physiological function
    • Robinson RB, Siegelbaum SA. Hyperpolarization-activated cation currents: from molecules to physiological function. Annu Rev Physiol 2003; 65:453-480.
    • (2003) Annu Rev Physiol , vol.65 , pp. 453-480
    • Robinson, R.B.1    Siegelbaum, S.A.2
  • 29
    • 10744228523 scopus 로고    scopus 로고
    • Adult cardiac stem cells are multipotent and support myocardial regeneration
    • Beltrami AP, Barlucchi L, Torella D, et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003; 114:763-776.
    • (2003) Cell , vol.114 , pp. 763-776
    • Beltrami, A.P.1    Barlucchi, L.2    Torella, D.3
  • 30
    • 0142027772 scopus 로고    scopus 로고
    • Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction
    • Oh H, Bradfute SB, Gallardo TD, et al. Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A 2003; 100:12313-12318.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 12313-12318
    • Oh, H.1    Bradfute, S.B.2    Gallardo, T.D.3
  • 31
    • 12144287908 scopus 로고    scopus 로고
    • Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes
    • Matsuura K, Nagai T, Nishigaki N, et al. Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes. J Biol Chem 2004; 279:11384-11391.
    • (2004) J Biol Chem , vol.279 , pp. 11384-11391
    • Matsuura, K.1    Nagai, T.2    Nishigaki, N.3
  • 32
    • 0347623124 scopus 로고    scopus 로고
    • Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart
    • Martin CM, Meeson AP, Robertson SM, et al. Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart. Dev Biol 2004; 265:262-275.
    • (2004) Dev Biol , vol.265 , pp. 262-275
    • Martin, C.M.1    Meeson, A.P.2    Robertson, S.M.3
  • 33
    • 22144476853 scopus 로고    scopus 로고
    • CD31- but Not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation
    • Pfister O, Mouquet F, Jain M, et al. CD31- but Not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation. Circ Res 2005; 97:52-61.
    • (2005) Circ Res , vol.97 , pp. 52-61
    • Pfister, O.1    Mouquet, F.2    Jain, M.3
  • 34
    • 7244261795 scopus 로고    scopus 로고
    • Isolation and expansion of adult cardiac stem cells from human and murine heart
    • Messina E, De Angelis L, Frati G, et al. Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ Res 2004; 95:911-921.
    • (2004) Circ Res , vol.95 , pp. 911-921
    • Messina, E.1    De Angelis, L.2    Frati, G.3
  • 35
    • 33645837819 scopus 로고    scopus 로고
    • Life and death of cardiac stem cells: A paradigm shift in cardiac biology
    • Anversa P, Kajstura J, Leri A, Bolli R. Life and death of cardiac stem cells: a paradigm shift in cardiac biology. Circulation 2006; 113:1451-1463.
    • (2006) Circulation , vol.113 , pp. 1451-1463
    • Anversa, P.1    Kajstura, J.2    Leri, A.3    Bolli, R.4
  • 36
    • 33847145871 scopus 로고    scopus 로고
    • Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens
    • This study described a method for isolation and expansion of human adult cardiac stem cells from a routine endomyocardial biopsy. These stem cells could differentiate into cardiomyocytes upon co-culture with rat myocytes and improved cardiac function when injected into mouse infarct model
    • Smith RR, Barile L, Cho HC, et al. Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation 2007; 115:896-908. This study described a method for isolation and expansion of human adult cardiac stem cells from a routine endomyocardial biopsy. These stem cells could differentiate into cardiomyocytes upon co-culture with rat myocytes and improved cardiac function when injected into mouse infarct model.
    • (2007) Circulation , vol.115 , pp. 896-908
    • Smith, R.R.1    Barile, L.2    Cho, H.C.3
  • 37
    • 33847165498 scopus 로고    scopus 로고
    • Electrophysiology of human and porcine adult cardiac stem cells isolated from endomyocardial biopsies
    • Cho HC, Smith R, Abraham M, et al. Electrophysiology of human and porcine adult cardiac stem cells isolated from endomyocardial biopsies. Heart Rhythm 2005; 2:S45.
    • (2005) Heart Rhythm , vol.2
    • Cho, H.C.1    Smith, R.2    Abraham, M.3
  • 38
    • 30644474936 scopus 로고    scopus 로고
    • Unique phenotype of cardiospheres derived from human endomyocardial biopsies
    • Smith R, Barile L, Cho HC, et al. Unique phenotype of cardiospheres derived from human endomyocardial biopsies. Circulation 2005; 112:II-51.
    • (2005) Circulation , vol.112 , Issue.II-51
    • Smith, R.1    Barile, L.2    Cho, H.C.3
  • 39
    • 0035221762 scopus 로고    scopus 로고
    • Human embryonic stem cell research: Ethical and legal issues
    • Robertson JA. Human embryonic stem cell research: ethical and legal issues. Nat Rev Genet 2001; 2:74-78.
    • (2001) Nat Rev Genet , vol.2 , pp. 74-78
    • Robertson, J.A.1
  • 41
    • 0034983625 scopus 로고    scopus 로고
    • Multilineage differentiation from human embryonic stem cell lines
    • Odorico JS, Kaufman DS, Thomson JA. Multilineage differentiation from human embryonic stem cell lines. Stem Cells 2001; 19:193-204.
    • (2001) Stem Cells , vol.19 , pp. 193-204
    • Odorico, J.S.1    Kaufman, D.S.2    Thomson, J.A.3
  • 42
    • 0029153291 scopus 로고
    • The pacemaker current (I(f)) plays an important role in regulating SA node pacemaker activity
    • DiFrancesco D. The pacemaker current (I(f)) plays an important role in regulating SA node pacemaker activity. Cardiovasc Res 1995; 30:307-308.
    • (1995) Cardiovasc Res , vol.30 , pp. 307-308
    • DiFrancesco, D.1
  • 43
    • 0032970234 scopus 로고    scopus 로고
    • The HCN gene family: Molecular basis of the hyperpolarization-activated pacemaker channels
    • Santoro B, Tibbs GR. The HCN gene family: molecular basis of the hyperpolarization-activated pacemaker channels. Ann N Y Acad Sci 1999; 868:741-764.
    • (1999) Ann N Y Acad Sci , vol.868 , pp. 741-764
    • Santoro, B.1    Tibbs, G.R.2
  • 44
    • 0035794167 scopus 로고    scopus 로고
    • Functional heteromerization of HCN1 and HCN2 pacemaker channels
    • Ulens C, Tytgat J. Functional heteromerization of HCN1 and HCN2 pacemaker channels. J Biol Chem 2001; 276:6069-6072.
    • (2001) J Biol Chem , vol.276 , pp. 6069-6072
    • Ulens, C.1    Tytgat, J.2
  • 45
    • 17444429283 scopus 로고    scopus 로고
    • Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures
    • Brewster AL, Bernard JA, Gall CM, Baram TZ. Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures. Neurobiol Dis 2005; 19:200-207.
    • (2005) Neurobiol Dis , vol.19 , pp. 200-207
    • Brewster, A.L.1    Bernard, J.A.2    Gall, C.M.3    Baram, T.Z.4
  • 46
    • 0031041032 scopus 로고    scopus 로고
    • Characterization of the hyperpolarization-activated current, I(f), in ventricular myocytes from human failing heart
    • Cerbai E, Pino R, Porciatti F, et al. Characterization of the hyperpolarization-activated current, I(f), in ventricular myocytes from human failing heart. Circulation 1997; 95:568-571.
    • (1997) Circulation , vol.95 , pp. 568-571
    • Cerbai, E.1    Pino, R.2    Porciatti, F.3
  • 47
    • 0031963215 scopus 로고    scopus 로고
    • Hyperpolarization- activated inward current in ventricular myocytes from normal and failing human hearts
    • Hoppe UC, Jansen E, Sudkamp M, Beuckelmann DJ. Hyperpolarization- activated inward current in ventricular myocytes from normal and failing human hearts. Circulation 1998; 97:55-65.
    • (1998) Circulation , vol.97 , pp. 55-65
    • Hoppe, U.C.1    Jansen, E.2    Sudkamp, M.3    Beuckelmann, D.J.4
  • 48
    • 0021132203 scopus 로고
    • The ionic currents underlying pacemaker activity in rabbit sino-atrial node: Experimental results and computer simulations
    • Brown HF, Kimura J, Noble D, et al. The ionic currents underlying pacemaker activity in rabbit sino-atrial node: experimental results and computer simulations. Proc R Soc Lond B Biol Sci 1984; 222:329-347.
    • (1984) Proc R Soc Lond B Biol Sci , vol.222 , pp. 329-347
    • Brown, H.F.1    Kimura, J.2    Noble, D.3
  • 49
    • 33750203720 scopus 로고    scopus 로고
    • Kashiwakura Y, Cho HC, Barth AS, et al. Gene transfer of a synthetic pacemaker channel into the heart: a novel strategy for biological pacing. Circulation 2006; 114:1682-1686. Combination of three mutations in the S4 region and one mutation in the pore region of human Kv1.4 channel converted the wild-type channel to a synthetic pacemaker channel. The expression of this synthetic channel induced ectopic ventricular pacemaker activity upon focal injection.
    • Kashiwakura Y, Cho HC, Barth AS, et al. Gene transfer of a synthetic pacemaker channel into the heart: a novel strategy for biological pacing. Circulation 2006; 114:1682-1686. Combination of three mutations in the S4 region and one mutation in the pore region of human Kv1.4 channel converted the wild-type channel to a synthetic pacemaker channel. The expression of this synthetic channel induced ectopic ventricular pacemaker activity upon focal injection.
  • 50
    • 0029862914 scopus 로고    scopus 로고
    • Conversion of a delayed rectifier K+ channel to a voltage-gated inward rectifier K+ channel by three amino acid substitutions
    • Miller AG, Aldrich RW. Conversion of a delayed rectifier K+ channel to a voltage-gated inward rectifier K+ channel by three amino acid substitutions. Neuron 1996; 16:853-858.
    • (1996) Neuron , vol.16 , pp. 853-858
    • Miller, A.G.1    Aldrich, R.W.2
  • 52
    • 0033582978 scopus 로고    scopus 로고
    • Potential molecular basis of different physiological properties of the transient outward K+ current in rabbit and human atrial myocytes
    • Wang Z, Feng J, Shi H, et al. Potential molecular basis of different physiological properties of the transient outward K+ current in rabbit and human atrial myocytes. Circ Res 1999; 84:551-561.
    • (1999) Circ Res , vol.84 , pp. 551-561
    • Wang, Z.1    Feng, J.2    Shi, H.3
  • 53
    • 34547886502 scopus 로고    scopus 로고
    • Xenografted adult human mesenchymal stem cells provide a platform for sustained biological pacemaker function in canine heart
    • Plotnikov AN, Shlapakova I, Szabolcs MJ, et al. Xenografted adult human mesenchymal stem cells provide a platform for sustained biological pacemaker function in canine heart. Circulation 2007; 116:706-713.
    • (2007) Circulation , vol.116 , pp. 706-713
    • Plotnikov, A.N.1    Shlapakova, I.2    Szabolcs, M.J.3
  • 54
    • 11144357199 scopus 로고    scopus 로고
    • Human mesenchymal stem cells as a gene delivery system to create cardiac pacemakers
    • Potapova I, Plotnikov A, Lu Z, et al. Human mesenchymal stem cells as a gene delivery system to create cardiac pacemakers. Circ Res 2004; 94:952-959.
    • (2004) Circ Res , vol.94 , pp. 952-959
    • Potapova, I.1    Plotnikov, A.2    Lu, Z.3
  • 55
    • 0036213942 scopus 로고    scopus 로고
    • Cardiac gap junctions and connexins: Their role in atrial fibrillation and potential as therapeutic targets
    • van der Velden HM, Jongsma HJ. Cardiac gap junctions and connexins: their role in atrial fibrillation and potential as therapeutic targets. Cardiovasc Res 2002; 54:270-279.
    • (2002) Cardiovasc Res , vol.54 , pp. 270-279
    • van der Velden, H.M.1    Jongsma, H.J.2
  • 56
    • 34247590394 scopus 로고    scopus 로고
    • Creation of a biological pacemaker by cell fusion
    • Syngeneic fibroblasts stably expressing HCN1 channels were fused to myocardium and the resulting heterokaryons developed spontaneously oscillating action potentials. The ECGs from such animals showed ectopic rhythms originating from the site of somatic cell fusion
    • Cho HC, Kashiwakura Y, Marban E. Creation of a biological pacemaker by cell fusion. Circ Res 2007; 100:1112-1115. Syngeneic fibroblasts stably expressing HCN1 channels were fused to myocardium and the resulting heterokaryons developed spontaneously oscillating action potentials. The ECGs from such animals showed ectopic rhythms originating from the site of somatic cell fusion.
    • (2007) Circ Res , vol.100 , pp. 1112-1115
    • Cho, H.C.1    Kashiwakura, Y.2    Marban, E.3
  • 57
    • 0031604598 scopus 로고    scopus 로고
    • Cell hybridization, hybridomas, and human hybridomas
    • Shirahata S, Katakura Y, Teruya K. Cell hybridization, hybridomas, and human hybridomas. Methods Cell Biol 1998; 57:111-145.
    • (1998) Methods Cell Biol , vol.57 , pp. 111-145
    • Shirahata, S.1    Katakura, Y.2    Teruya, K.3
  • 58
    • 0033494206 scopus 로고    scopus 로고
    • Poly(ethylene glycol) (PEG)-mediated fusion between pure lipid bilayers: A mechanism in common with viral fusion and secretory vesicle release?
    • Lentz BR, Lee JK. Poly(ethylene glycol) (PEG)-mediated fusion between pure lipid bilayers: a mechanism in common with viral fusion and secretory vesicle release? Mol Membr Biol 1999; 16:279-296.
    • (1999) Mol Membr Biol , vol.16 , pp. 279-296
    • Lentz, B.R.1    Lee, J.K.2
  • 59
    • 0033617371 scopus 로고    scopus 로고
    • Manipulation of cellular excitability by cell fusion: Effects of rapid introduction of transient outward K+ current on the guinea pig action potential
    • Hoppe UC, Johns DC, Marban E, O'Rourke B. Manipulation of cellular excitability by cell fusion: effects of rapid introduction of transient outward K+ current on the guinea pig action potential. Circ Res 1999; 84:964-972.
    • (1999) Circ Res , vol.84 , pp. 964-972
    • Hoppe, U.C.1    Johns, D.C.2    Marban, E.3    O'Rourke, B.4
  • 60
    • 0028872320 scopus 로고
    • Dermal fibroblasts convert to a myogenic lineage in mdx mouse muscle
    • Gibson AJ, Karasinski J, Relvas J, et al. Dermal fibroblasts convert to a myogenic lineage in mdx mouse muscle. J Cell Sci 1995; 108 (Pt 1):207-214.
    • (1995) J Cell Sci , vol.108 , Issue.PART 1 , pp. 207-214
    • Gibson, A.J.1    Karasinski, J.2    Relvas, J.3
  • 61
    • 0036736786 scopus 로고    scopus 로고
    • Long-term persistence of donor nuclei in a Duchenne muscular dystrophy patient receiving bone marrow transplantation
    • Gussoni E, Bennett RR, Muskiewicz KR, et al. Long-term persistence of donor nuclei in a Duchenne muscular dystrophy patient receiving bone marrow transplantation. J Clin Invest 2002; 110:807-814.
    • (2002) J Clin Invest , vol.110 , pp. 807-814
    • Gussoni, E.1    Bennett, R.R.2    Muskiewicz, K.R.3
  • 62
    • 0242584006 scopus 로고    scopus 로고
    • Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
    • Alvarez-Dolado M, Pardal R, Garcia-Verdugo JM, et al. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 2003; 425:968-973.
    • (2003) Nature , vol.425 , pp. 968-973
    • Alvarez-Dolado, M.1    Pardal, R.2    Garcia-Verdugo, J.M.3
  • 63
    • 0242575218 scopus 로고    scopus 로고
    • Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant
    • Weimann JM, Johansson CB, Trejo A, Blau HM. Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant. Nat Cell Biol 2003; 5:959-966.
    • (2003) Nat Cell Biol , vol.5 , pp. 959-966
    • Weimann, J.M.1    Johansson, C.B.2    Trejo, A.3    Blau, H.M.4
  • 64
    • 34547866713 scopus 로고    scopus 로고
    • Rosen AB, Kelly DJ, Schuldt AJ, et al. Finding fluorescent needles in the cardiac haystack: tracking human mesenchymal stem cells labeled with quantum dots for quantitative in vivo three-dimensional fluorescence analysis. Stem Cells 2007; 25:2128-2138. Quantum dot nanoparticles were used to track the fate of human mesenchymal stem cells upon injection intomammalian heart. After accounting for cell death and leakage of the nanoparticles, only about 30% of the injected cells still remain in the heart.
    • Rosen AB, Kelly DJ, Schuldt AJ, et al. Finding fluorescent needles in the cardiac haystack: tracking human mesenchymal stem cells labeled with quantum dots for quantitative in vivo three-dimensional fluorescence analysis. Stem Cells 2007; 25:2128-2138. Quantum dot nanoparticles were used to track the fate of human mesenchymal stem cells upon injection intomammalian heart. After accounting for cell death and leakage of the nanoparticles, only about 30% of the injected cells still remain in the heart.
  • 65
    • 33847131205 scopus 로고    scopus 로고
    • Conversion of nonexcitable cells to self-contained biological pacemakers
    • Cho HC, Kashiwakura Y, Marban E. Conversion of nonexcitable cells to self-contained biological pacemakers. Circulation 2005; 112:II-307.
    • (2005) Circulation , vol.112 , Issue.II-307
    • Cho, H.C.1    Kashiwakura, Y.2    Marban, E.3
  • 66
    • 0035861457 scopus 로고    scopus 로고
    • A prokaryotic voltage-gated sodium channel
    • Ren D, Navarro B, Xu H, et al. A prokaryotic voltage-gated sodium channel. Science 2001; 294:2372-2375.
    • (2001) Science , vol.294 , pp. 2372-2375
    • Ren, D.1    Navarro, B.2    Xu, H.3
  • 67
    • 21744440389 scopus 로고    scopus 로고
    • Nonequilibrium behavior of HCN channels: Insights into the role of HCN channels in native and engineered pacemakers
    • Azene EM, Xue T, Marban E, et al. Nonequilibrium behavior of HCN channels: insights into the role of HCN channels in native and engineered pacemakers. Cardiovasc Res 2005; 67:263-273.
    • (2005) Cardiovasc Res , vol.67 , pp. 263-273
    • Azene, E.M.1    Xue, T.2    Marban, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.