Inhibitory mechanism of serpins. Identification of steps involving the active-site serine residue of the protease

Journal of Molecular Biology

Volumn 265, Issue 3, 1997, Pages 344-362

  Stone, Stuart R ^a,b   Le Bonniec, Bernard F ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Heparin; Inhibitory mechanism; Protease; Serpin; Thrombin

Indexed keywords

ALANINE; ALPHA 1 ANTITRYPSIN; ANTITHROMBIN; HEPARIN; HIRUDIN; PROTEASE NEXIN; PROTEINASE; SERINE; SERINE PROTEINASE INHIBITOR;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISSOCIATION CONSTANT; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME MECHANISM; ENZYME STRUCTURE; PRIORITY JOURNAL;

EID: 0031053519     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1996.0727     Document Type: Article

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