Enzymatic excision of uracil residues in nucleosomes depends on the local DNA structure and dynamics

Biochemistry

Volumn 51, Issue 30, 2012, Pages 6028-6038

  Ye, Yu ^a   Stahley, Mary R ^a   Xu, Jianqing ^b   Friedman, Joshua I ^a   Sun, Yan ^a   McKnight, Jeffrey N ^c   Gray, Jeffrey J ^b   Bowman, Gregory D ^c   Stivers, James T ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Johns Hopkins University   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BASE PAIRS; CONFORMATIONAL DYNAMICS; DNA STRUCTURE; KINETIC MEASUREMENT; MINOR GROOVES; NUCLEOSOME CORE PARTICLES; NUCLEOSOMES; RATE LIMITING; REACTION MECHANISM; REACTIVE SITE; STERIC EFFECT; STRUCTURAL MODELS; URACIL-DNA GLYCOSYLASE; XENOPUS LAEVIS;

DNA; ENZYMES; KINETICS; MODEL STRUCTURES; REACTION KINETICS;

AROMATIC COMPOUNDS;

DNA; URACIL DNA GLYCOSIDASE;

ARTICLE; DNA SEQUENCE; DNA STRUCTURE; ENZYMATIC EXCISION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; MOLECULAR DOCKING; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; STEADY STATE; XENOPUS LAEVIS;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; DNA; DNA REPAIR; NUCLEOSOMES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; URACIL; XENOPUS LAEVIS;

XENOPUS LAEVIS;

EID: 84864447350     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi3006412     Document Type: Article

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