Turning On Uracil-DNA Glycosylase Using a Pyrene Nucleotide Switch

Journal of Biological Chemistry

Volumn 276, Issue 45, 2001, Pages 42347-42354

  Jiang, Yu Lin ^b   Kwon, Keehwan ^b   Stivers, James T ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYST ACTIVITY; DNA; ENZYME IMMOBILIZATION; HYDROLYSIS;

BINDING AFFINITY;

BIOCHEMISTRY;

AMINO ACID; DEOXYURIDINE; DNA BASE; GLYCOSIDE; LEUCINE; NUCLEOTIDE; PYRENE; URACIL; URACIL DNA GLYCOSYLTRANSFERASE; DNA; DNA GLYCOSYLTRANSFERASE; GLYCOSIDASE; PEROXIDE; POTASSIUM MANGANESE PEROXIDE; PYRENE DERIVATIVE; URACIL DNA GLYCOSIDASE;

ARTICLE; BASE FLIPPING; BINDING AFFINITY; CATALYSIS; CHEMICAL BOND; CONTROLLED STUDY; DNA CONFORMATION; DNA STRAND; ENZYME ACTIVE SITE; ENZYME MECHANISM; EXCISION REPAIR; GENETIC CONSERVATION; HYDROLYSIS; MOLECULAR RECOGNITION; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; CHEMISTRY; METABOLISM; OXIDATION REDUCTION REACTION;

CATALYSIS; DNA; DNA GLYCOSYLASES; N-GLYCOSYL HYDROLASES; OXIDATION-REDUCTION; PEROXIDES; PYRENES; URACIL; URACIL-DNA GLYCOSIDASE;

EID: 0035834751     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M106594200     Document Type: Article

References (32)

1. Cheng, X., and Blumenthal, R. M. (1996) Structure 4, 639-645
2. Parikh, S. S., Mol, C. D., Hosfield, D. J., and Tainer, J. A. (1999) Curr. Opin. Struct. Biol. 9, 37-47
3. Parikh, S. S., Walcher, G., Jones, G. D., Slupphaug, G., Krokan, H. E., Blackburn, G. M., and Tainer, J. A. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 5083-5088
4. Parikh, S. S., Mol, C. D., Slupphaug, G., Bharati, S., Krokan, H. E., and Tainer, J. A. (1998) EMBO J. 17, 5214-5226
5. Werner, R. M., Jiang, Y. L., Gordley, R. G., Jagadeesh, G. J., Ladner, J. E., Xiao, G., Tordova, M., Gilliland, G. L., and Stivers, J. T. (2000) Biochemistry 39, 12585-12594
6. Hollis, T., Ichikawa, Y., and Ellenberger, T. (2000) EMBO J. 19, 758-766
7. Lau, A. Y., Scharer, O. D., Samson, L., Verdine, G. L., and Ellenberger, T. (1998) Cell 95, 249-258
8. Stivers, J. T., Pankiewicz, K. W., and Watanabe, K. A. (1999) Biochemistry 38, 952-963
9. Xiao, G., Tordova, M., Jagadeesh, J., Drohat, A. C., Stivers, J. T., and Gilliland, G. L. (1999) Proteins 35, 13-24
10. Higley, M., and Lloyd, R. S. (1993) Mutat. Res. 294, 109-116
11. Bennett, S. E., Sanderson, R. J., and Mosbaugh, D. W. (1995) Biochemistry 34, 6109-6119
12. Verdine, G. L., and Bruner, S. D. (1997) Chem. Biol. 4, 329-334
13. Kool, E. T., Morales, J. C., and Guckian, K. M. (2000) Angew. Chem.-Int. Ed. 39, 990-1009
14. Ren, R. X. F., Chaudhuri, N. C., Paris, P. L., Rumney, S., and Kool, E. T. (1996) J. Am. Chem. Soc. 118, 7671-7678
15. Schweitzer, B. A., and Kool, E. T. (1994) J. Org. Chem. 59, 7238-7242
16. Fasman, G. D. (1975) Handbook of Biochemistry and Molecular Biology: Nucleic Acids Vol. 1, 3rd Ed., 1, CRC Press, Boca Raton, FL
17. Drohat, A. C., Jagadeesh, J., Ferguson, E., and Stivers, J. T. (1999) Biochemistry 38, 11866-11875
18. Lindahl, T. (1974) Proc. Natl. Acad. Sci. U. S. A. 71, 3649-3653
19. Stivers, J. T. (1998) Nucleic Acids Res. 26, 3837-3844
20. Jiang, Y. L., and Stivers, J. T. (2001) Biochemistry 40, 7710-7719
21. Morales, J. C., and Kool, E. T. (1998) Nat. Struct. Biol. 5, 950-954
22. Matray, T. J., and Kool, E. T. (1999) Nature 399, 704-708
23. Matray, T. J., and Kool, E. T. (1998) J. Am. Chem. Soc. 120, 6191-6192
24. Drohat, A. C., Xiao, G., Tordova, M., Jagadeesh, J., Pankiewicz, K. W., Watanabe, K. A., Gilliland, G. L., and Stivers, J. T. (1999) Biochemistry 38, 11876-11886
25. Drohat, A. C., and Stivers, J. T. (2000) Biochemistry 39, 11865-11875
26. Rubin, C. M., and Schmid, C. W. (1980) Nucleic Acids Res. 8, 4613-4619
27. Hayatsu, H., and Ukita, T. (1967) Biochem. Biophys. Res. Commun. 29, 556-561
28. Jones, A. S., and Walker, R. T. (1963) J. Chem. Soc. 3554-3557
29. Fersht, A. (1985) Enzyme Structure and Mechanism, pp. 98-112, W. H. Freeman and Company, New York
30. Handa, P., Roy, S., and Varshney, U. (2001) J. Biol. Chem. 276, 17324-17331
31. Law, S. M., Eritja, R., Goodman, M. F., and Breslauer, K. J. (1996) Biochemistry 35, 12329-12337
32. Kavli, B., Slupphaug, G., Mol, C. D., Arvai, A. S., Peterson, S. B., Tainer, J. A., and Krokan, H. E. (1996) EMBO J. 15, 3442-3447