IL-6-induced activation of MYC is responsible for the down-regulation of CD33 expression in CD33(+) myeloma cells

International Journal of Hematology

Volumn 89, Issue 3, 2009, Pages 310-318

  Shamsasenjan, Karim ^a   Otsuyama, Ken Ichiro ^a   Abroun, Saeid ^a   Iqbal, Mohd S ^a   Mahmoud, Maged S ^b   Asaoku, Hideki ^c   Kawano, Michio M ^a  

^a YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Assiut University Faculty of Medicine   (Egypt)

^c ATOMIC BOMB SURVIVORS HOSPITAL   (Japan)

Author keywords

C MYC; C EBP ; CD33; IL 6; Multiple myeloma

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; C REACTIVE PROTEIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; CD33 ANTIGEN; CUCURBITACIN; INTERLEUKIN 6; MYC PROTEIN; STAT3 PROTEIN; CCAAT ENHANCER BINDING PROTEIN; CEBPA PROTEIN, HUMAN; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN; STAT3 PROTEIN, HUMAN;

ARTICLE; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MYELOMA CELL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; MULTIPLE MYELOMA; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL CULTURE;

ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CCAAT-ENHANCER-BINDING PROTEINS; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERLEUKIN-6; MULTIPLE MYELOMA; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-MYC; STAT3 TRANSCRIPTION FACTOR; TUMOR CELLS, CULTURED;

EID: 67649203124     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12185-009-0256-y     Document Type: Article

References (28)

1. B Adams P Dorfler A Aguzzi 1992 Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis Genes Dev 6 1589 1607 10.1101/gad.6.9.1589
2. Z Kozmik S Wang P Dorfler B Adams M Busslinger 1992 The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP Mol Cell Biol 12 2662 2672
3. KI Lin C Angelin-Duclos TC Kuo K Calame 2002 Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells Mol Cell Biol 22 4771 4780 10.1128/MCB.22.13.4771-4780. 2002 (Pubitemid 34620412)
4. H Harada MM Kawano N Huang 1993 Phenotypic difference of normal plasma cells from mature myeloma cells Blood 81 2658 2663
5. N Huang MM Kawano H Harada 1993 Heterogeneous expression of a novel MPC-1 antigen on myeloma cells: possible involvement of MPC-1 antigen in the adhesion of mature myeloma cells to bone marrow stromal cells Blood 82 3721 3729
6. B Van Camp BG Durie C Spier 1990 Plasma cells in multiple myeloma express a natural killer cell-associated antigen: CD56 (NKH-1; Leu-19) Blood 76 377 382
7. CM Spier TM Grogan BG Durie 1990 T-cell antigen-positive multiple myeloma Mod Pathol 3 302 307
8. GJ Ruiz-Arguelles JF San Miguel 1994 Cell surface markers in multiple myeloma Mayo Clin Proc 69 684 690
9. SC Peiper RA Ashmun T Look 1988 Molecular cloning, expression, and chromosomal localization of a human gene encoding the CD33 myeloid differentiation antigen Blood 72 314 321
10. D Simmons B Seed 1988 Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells J Immunol 141 2797 2800
11. PR Crocker 2002 Siglecs: sialic-acid-binding immunoglobulin-like lectins in cell-cell interactions and signaling Curr Opin Struct Biol 12 609 615 10.1016/S0959-440X(02)00375-5 (Pubitemid 35449068)
12. PR Crocker A Varki 2001 Siglecs, sialic acids and innate immunity Trends Immunol 22 337 342 10.1016/S1471-4906(01)01930-5 (Pubitemid 32675248)
13. G Mateo M Castellanos A Rasillo 2005 Genetic abnormalities and patterns of antigenic expression in multiple myeloma Clin Cancer Res 11 3661 3667 10.1158/1078-0432.CCR-04-1489 (Pubitemid 40685582)
14. N Sahara K Ohnishi T Ono 2006 Clinicopathological and prognostic characteristics of CD33-positive multiple myeloma Eur J Haematol 77 14 18 10.1111/j.1600-0609.2006.00661.x (Pubitemid 43876200)
15. MM Kawano MS Mahmoud H Ishikawa 1997 Cyclin D1 and p16INK4A are preferentially expressed in immature and mature myeloma cells, respectively Br J Haematol 99 131 138 10.1046/j.1365-2141.1997.3473161.x
16. S Shimizu R Yoshioka Y Hirose S Sugai J Tachibana S Konda 1989 Establishment of two interleukin 6 (B cell stimulatory factor 2/interferon beta 2)-dependent human bone marrow-derived myeloma cell lines J Exp Med 169 339 344 10.1084/jem.169.1.339 (Pubitemid 19035566)
17. T Nagai M Ogura Y Morishita 1991 Establishment and characterization of a new human Bence Jones-type myeloma cell line, NOP-2 Int J Hematol 54 141 149
18. S Shimizu T Takiguchi M Fukutoku 1993 Establishment of a CD4-positive plasmacytoma cell line (AMO1) Leukemia 7 274 280
19. MP Bodger DN Hart 1998 Molecular cloning and functional analysis of the CD33 promoter Br J Haematol 102 986 995 10.1046/j.1365-2141.1998.00863.x (Pubitemid 28410530)
20. S Liu K Otsuyama Z Ma 2007 Induction of multilineage markers in humna myeloma cells and their down-regulation by interleukin 6 Int J Hematol 85 49 58 10.1532/IJH97.06132 (Pubitemid 46193290)
21. S Liu H Ishikawa F Li 2005 Dehydroepiandrosterone can inhibit the proliferation of myeloma cells and the interleukin-6 production of bone marrow mononuclear cells from patients with myeloma Cancer Res 65 2269 2276 10.1158/0008-5472.CAN-04-3079 (Pubitemid 40490136)
22. M Kawano T Hirano T Matsuda 1988 Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas Nature 332 83 85 10.1038/332083a0 (Pubitemid 18083553)
23. B Klein XG Zhang M Jourdan 1989 Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6 Blood 73 517 526
24. T Hirano K Nakajima M Hibi 1997 Signaling mechanisms through gp130: a model of the cytokine system Cytokine Growth Factor Rev 8 241 252 10.1016/S1359-6101(98)80005-1 (Pubitemid 28202436)
25. P Antonson MG Pray A Jacobsson KG Xanthopoulos 1995 Myc inhibits CCAAT/enhancer-binding protein alpha-gene expression in HIB-1B hibernoma cells through interactions with the core promoter region Eur J Biochem 232 397 403 10.1111/j.1432-1033.1995.397zz.x
26. AA Zada JA Pulikkan D Bararia 2006 Proteomic discovery of Max as a novel interacting partner of C/EBPalpha: a Myc/Max/Mad link Leukemia 20 2137 2146 10.1038/sj.leu.2404438 (Pubitemid 44782839)
27. C Legraverend P Antonson P Flodby KG Xanthopoulos 1993 High level activity of the mouse CCAAT/enhancer binding protein (C/EBP alpha) gene promoter involves autoregulation and several ubiquitous transcription factors Nucleic Acids Res 21 1735 1742 10.1093/nar/21.8.1735
28. P Cartwright C McLean A Sheppard D Rivett K Jones S Dalton 2005 LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism Development 132 885 896 10.1242/dev.01670 (Pubitemid 40484924)