Inhibition of sphingosine kinase 1 enhances cytotoxicity, ceramide levels and ROS formation in liver cancer cells treated with selenite

Biochemical Pharmacology

Volumn 84, Issue 5, 2012, Pages 712-721

  Chatzakos, V ^a,b   Rundlof A K ^a   Ahmed, D ^a   De Verdier, P J ^a   Flygare, J ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Ceramide; Hepatocellular carcinoma; ROS; Selenite; Sphingolipids

Indexed keywords

2 (4 HYDROXYANILINO) 4 (4 CHLOROPHENYL)THIAZOLE; 3 O METHYLSPHINGOSINE; CERAMIDE; REACTIVE OXYGEN METABOLITE; SELENITE; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE KINASE 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL VIABILITY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INCUBATION TIME; LIPID METABOLISM; LIVER CELL CARCINOMA; PRIORITY JOURNAL;

BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SURVIVAL; CERAMIDES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LIVER NEOPLASMS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); REACTIVE OXYGEN SPECIES; SODIUM SELENITE; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 84864401466     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.06.009     Document Type: Article

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