In vitro and in vivo biological evaluation of new 4,5-disubstituted 1,2,3-triazoles as cis-constrained analogs of combretastatin A4

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 22-32

  Mur Blanch, Núria ^a   Chabot, Guy G ^b,c   Quentin, Lionel ^b,c   Scherman, Daniel ^b,c   Bourg, Stéphane ^d   Dauzonne, Daniel ^a  

^a CNRS   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c Centre National de la Recherche Scientifique   (France)

^d UNIVERSITÉ D'ORLÉANS   (France)

Author keywords

Antivascular agents; Combretastatin analogs; Cytotoxicity; Endothelial cells; Triazoles; Tubulin polymerization

Indexed keywords

1 (3 FLUORO 4 METHOXYPHENYL) 3 (3,4,5 TRIMETHOXYPHENYL) 2 NITROPROPENE; 1 (4 METHOXY 3 NITROPHENYL) 3 (3,4,5 TRIMETHOXYPHENYL) 2 NITROPROPENE; 1,2,3 TRIAZOLE DERIVATIVE; 2 (3 HYDROXY 4 METHOXYOPHENYL) 1 NITROETHENE; 2 (3 HYDROXY 4 METHOXYPHENYL) 1 NITROETHANE; 2 (3,4,5 TRIMETHOXYPHENYL) 1 NITROETHANE; 2 (3,4,5 TRIMETHOXYPHENYL) 1 NITROETHENE; 3 (3 HYDROXY 4 METHOXYPHENYL) 1 (3,4,5 TRIMETHOXYPHENYL) 2 NITROPROPENE; 4 (3 HYDROXY 4 METHOXYBENZYL) 5 (3,4,5 TRIMETHOXYPHENYL) 1,2,3 TRIAZOLE; 4 (3 INDOLEMETHYL) 5 (3,4,5 TRIMETHOXYPHENYL) 1,2,3 TRIAZOLE; 4 (3,4,5 TRIMETHOXYBENZYL) 5 (3 HYDROXY 4 METHOXYPHENYL) 1,2,3 TRIAZOLE; 4 (3,4,5 TRIMETHOXYBENZYL) 5 (4 HYDROXY 3 METHOXYPHENYL) 1,2,3 TRIAZOLE; 5 (2,4 DICHLOROPHENYL) 4 (3,4,5 TRIMETHOXYBENZYL) 1,2,3 TRIAZOLE; 5 (3 AMINO 4 METHOXYPHENYL) 4 (3,4,5 TRIMETHOXYBENZYL) 1,2,3 TRIAZOLE; 5 (3 FLUORO 4 METHOXYPHENYL) 4 (3,4,5 TRIMETHOXYBENZYL) 1,2,3 TRIAZOLE; 5 (4 METHOXY 3 NITROPHENYL) 4 (3,4,5 TRIMETHOXYBENZYL) 1,2,3 TRIAZOLE; 5 (BENZO[1,3]DIOXOL 5 YL) 4 (3,4,5 TRIMETHOXYBENZYL) 1,2,3 TRIAZOLE; COMBRETASTATIN A4; TUBULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRUCTURE; COLON CARCINOMA; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MELANOMA B16; MICROTUBULE ASSEMBLY; MOLECULAR MODEL; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS; CATALYTIC DOMAIN; CELL LINE, TUMOR; ENDOTHELIAL CELLS; FEMALE; HUMANS; MELANOMA, EXPERIMENTAL; MICE; MOLECULAR DOCKING SIMULATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; STEREOISOMERISM; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; TUBULIN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84864396780     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.04.017     Document Type: Article

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