Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 1, 2012, Pages 234-242

  Akselsen, Øyvind W ^a   Odlo, Kristin ^a   Cheng, Jing Jy ^b   MacCari, Giorgio ^c   Botta, Maurizio ^c   Hansen, Trond Vidar ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^c UNIVERSITY OF SIENA   (Italy)

Author keywords

1,2,3 Triazoles; Angiogenesis; Combretastatin A 1; Molecular modeling; Tubulin

Indexed keywords

1 [4 METHOXY 2,3 BIS(METHOXYMETHOXY)PHENYL] 5 (3,4,5 TRIMETHOXYPHENYL) 1H 1,2,3 TRIAZOLE; 1 AZIDO 4 METHOXY 2,3 BIS(METHOXYMETHOXY)BENZENE; 1 ETHYNYL 2,3 DIFLUORO 4 METHOXYBENZENE; 1 ETHYNYL 2,3 DINITRO 4 METHOXYBENZENE; 1,2,3 TRIAZOLE DERIVATIVE; 2,2 DIMETHYL 5 [1 (3,4,5 TRIMETHOXYPHENYL) 1H 1,2,3 TRIAZOL 5 YL]BENZO[D][1,3]DIOXOL 4 OL; 3 METHOXY 6 [1 (3,4,5 TRIMETHOXYPHENYL) 1H 1,2,3 TRIAZOL 1 YL]BENZENE 1,2 DIOL; 3 METHOXY 6 [1 (3,4,5 TRIMETHOXYPHENYL) 1H 1,2,3 TRIAZOL 4 YL]BENZENE 1,2 DIAMINE; 3 METHOXY 6 [1 (3,4,5 TRIMETHOXYPHENYL) 1H 1,2,3 TRIAZOL 5 YL]BENZENE 1,2 DIAMINE; 3 METHOXY 6 [1 (3,4,5 TRIMETHOXYPHENYL) 1H 1,2,3 TRIAZOL 5 YL]BENZENE 1,2 DIOL; 3 METHOXY 6 [5 (3,4,5 TRIMETHOXYPHENYL) 1H 1,2,3 TRIAZOL 1 YL]BENZENE 1,2 DIOL; 4 ( 4 METHOXY 2,3 DINITROPHENYL) 1 (3,4,5 TRIMETHOXYPHENYL) 1H 1,2,3 TRIAZOLE; 4 (4 METHOXY 2,3 DINITROPHENYL) 1 (3,4,5 TRIMETHOXYPHENYL) 1H 1,2,3 TRIAZOLE; 4 (METHOXYMETHOXY) 2,2 DIMETHYLBENZO[D][1,3]DIOXOLE 5 CARBALDEHYDE; 5 (2,3 DIFLUORO 4 METHOXYPHENYL) 1 (3,4,5 TRIMETHOXYPHENYL) 1H 1,2,3 TRIAZOLE; 5 [1 (3,4,5 TRIMETHOXYPHENYL) 1H 1,2,3 TRIAZOL 5 YL]BENZO[D][1,3]DIOXOL 4 OL; 5 [4 (METHOXYMETHOXY)BENZO[D][1,3]DIOXOL 5 YL] 1 (3,4,5 TRIMETHOXYPHENYL) 1H 1,2,3 TRIAZOLE; 5 [4 METHOXY 2,3 BIS(METHOXYMETHOXY)PHENYL] 1 (3,4,5 TRIMETHOXYPHENYL) 1H 1,2,3 TRIAZOLE; 5 ETHYNYL 4 (METHOXYMETHOXY)BENZO[D][1,3]DIOXOLE; ALPHA TUBULIN; BETA TUBULIN; COLCHICINE; COMBRETASTATIN; COMBRETASTATIN A1; UNCLASSIFIED DRUG;

ANTIANGIOGENIC ACTIVITY; ARTICLE; BINDING SITE; BIOLOGICAL ACTIVITY; CANCER INHIBITION; CONTROLLED STUDY; CYCLOADDITION; CYTOTOXICITY; DEPROTECTION REACTION; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING; MOLECULAR MODEL; POLYMERIZATION; REDUCTION KINETICS;

ANGIOGENESIS INHIBITORS; BINDING SITES; CELL LINE; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; POLYMERIZATION; PROTEIN STRUCTURE, TERTIARY; STILBENES; TRIAZOLES; TUBULIN; TUBULIN MODULATORS;

EID: 84855188922     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.11.010     Document Type: Article

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