HCN2 ion channels: An emerging role as the pacemakers of pain

Trends in Pharmacological Sciences

Volumn 33, Issue 8, 2012, Pages 456-463

  Emery, Edward C ^a   Young, Gareth T ^a   McNaughton, Peter A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

HCN; I h; inflammatory pain; ion channel; neuropathic pain; pain; PGE 2; sensory transduction

Indexed keywords

4 (N ETHYL N PHENYLAMINO) 1,2 DIMETHYL 6 (METHYLAMINO)PYRIMIDINIUM CHLORIDE; ADENYLATE CYCLASE; ANALGESIC AGENT; G PROTEIN COUPLED RECEPTOR; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE MODULATED 2 ION CHANNEL; ION CHANNEL; IVABRADINE; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; OXALIPLATIN; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE INHIBITOR; SODIUM CHANNEL NAV1.8; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ALLODYNIA; ANALGESIA; COLD SENSITIVITY; CYTOKINE PRODUCTION; DIABETIC NEUROPATHY; DRUG EFFICACY; DRUG SAFETY; HUMAN; HYPERPOLARIZATION; HYPERSENSITIVITY; INFLAMMATORY PAIN; MEMBRANE DEPOLARIZATION; MEMBRANE STEADY POTENTIAL; NEUROMODULATION; NEUROPATHIC PAIN; NOCICEPTIVE PAIN; NONHUMAN; OLFACTORY RECEPTOR; PAIN THRESHOLD; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; REVIEW; SIGNAL TRANSDUCTION; UPREGULATION;

ACTION POTENTIALS; ACUTE PAIN; ANIMALS; CYCLIC AMP; HUMANS; INFLAMMATION; ION CHANNELS; NEURALGIA; NOCICEPTIVE PAIN; PROSTAGLANDINS E; RECEPTORS, G-PROTEIN-COUPLED; SENSORY RECEPTOR CELLS;

EID: 84864283229     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2012.04.004     Document Type: Review

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