ZD 7288 inhibits T-type calcium current in rat hippocampal pyramidal cells

Neuroscience Letters

Volumn 439, Issue 3, 2008, Pages 275-280

  Sanchez Alonso J L ^a   Halliwell, J V ^b   Colino, A ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

CA1 area; Hyperpolarization activated cation currents; Low voltage activated Ca2+ channels; Wistar rats

Indexed keywords

4 (N ETHYL N PHENYLAMINO) 1,2 DIMETHYL 6 (METHYLAMINO)PYRIMIDINIUM CHLORIDE; 4 AMINOPYRIDINE; BARIUM DERIVATIVE; CALCIUM CHANNEL T TYPE; NIFEDIPINE; TETRODOTOXIN; TETRYLAMMONIUM CHLORIDE; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; DRUG MECHANISM; HIPPOCAMPUS; MEMBRANE CONDUCTANCE; NONHUMAN; OUTER MEMBRANE; PIPETTE; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; STEADY STATE; WHOLE CELL; WISTAR RAT;

ANIMALS; ANIMALS, NEWBORN; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, T-TYPE; CARDIOVASCULAR AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTRIC STIMULATION; HIPPOCAMPUS; MEMBRANE POTENTIALS; NICKEL; NIFEDIPINE; PATCH-CLAMP TECHNIQUES; PYRAMIDAL CELLS; PYRIMIDINES; RATS; RATS, WISTAR; SODIUM CHANNEL BLOCKERS; TETRODOTOXIN;

EID: 44649088202     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.05.016     Document Type: Article

References (17)

1. f) in guinea-pig dissociated sinoatrial node cells. Br. J. Pharmacol. 110 (1993) 343-349
2. Bucchi A., Tognati A., Milanesi R., Baruscotti M., and DiFrancesco D. Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels. J. Physiol. 572 (2006) 335-346
3. Chen C. ZD 7288 inhibits postsynaptic glutamate receptor-mediated responses at hippocampal perforant path-granule cell synapses. Eur. J. Neurosci. 19 (2004) 643-649
4. h channels in synaptic transmission and mossy fiber LTP. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 9538-9543
5. 2+ channel activity and regulates sperm function. Biochem. Biophys. Res. Commun. 311 (2003) 187-192
6. h) blocker ZD 7288 in hippocampal CA1 neurons. Pflugers Arch. 435 (1997) 99-106
7. Gomora J.C., Xu L., Enyeart J.A., and Enyeart J.J. Effect of mibefradil on voltage-dependent gating and kinetics of T-type Ca(2+) channels in cortisol-secreting cells. J. Pharmacol. Exp. Ther. 292 (2000) 96-103
8. Harris N.C., and Constanti A. Mechanism of block by ZD 7288 of the hyperpolarization-activated inward rectifying current in guinea pig substantia nigra neurons in vitro. J. Neurophysiol. 74 (1995) 2366-2378
9. Huguenard J.R. Low-threshold calcium currents in central nervous system neurons. Annu. Rev. Physiol. 58 (1996) 329-348
10. Kay A.R., and Wong R.K.S. Isolation of neurons suitable for patch-clamping from adult mammalian central nervous systems. J. Neurosci. Meth. 16 (1986) 227-238
11. h blockers have a potential of antiepileptic effects. Epilepsia 44 (2003) 20-24
12. Lüthi A., and McCormick D.A. H-current: properties of a neuronal and network pacemaker. Neuron 21 (1998) 9-12
13. McDonough S.I., and Bean B.P. Mibefradil inhibition of T-type calcium channels in cerebellar purkinje neurons. Mol. Pharmacol. 54 (1998) 1080-1087
14. h channel subunits, HCN1-4, in the rat brain. J. Comp. Neurol. 471 (2004) 241-276
15. Nowycky M.C., Fox A.P., and Tsien R.W. Three types of neuronal calcium channel with different calcium agonist sensitivity. Nature 316 (1985) 440-443
16. Perez Reyes E. Molecular physiology of low-voltage-activated T-type calcium channels. Physiol. Rev. 83 (2003) 117-161
17. Surges R., Sarvari M., Steffens M., and Els T. Characterization of rebound depolarization in hippocampal neurons. Biochem. Biophys. Res. Commun. 348 (2006) 1343-1349