Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability

FEBS Letters

Volumn 586, Issue 16, 2012, Pages 2225-2231

  Dolezelova, Pavlina ^a   Cetkovska, Katerina ^a   Vousden, Karen H ^b   Uldrijan, Stjepan ^a  

^a MASARYK UNIVERSITY   (Czech Republic)

^b BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

Acidic domain; Binding partner; Mdm2; Mutagenesis; p53 degradation; Ubiquitin ligase activity

Indexed keywords

AMINO ACID; PROTEASOME; PROTEIN C8ALPHA; PROTEIN MDM2; PROTEIN P53; PROTEIN S6B; TRANSCRIPTION FACTOR YY1; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; CONTROLLED STUDY; IMMUNOPRECIPITATION; MUTATIONAL ANALYSIS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN TARGETING; REGULATORY MECHANISM; UBIQUITINATION;

AMINO ACID SEQUENCE; DNA MUTATIONAL ANALYSIS; GENE DELETION; HEK293 CELLS; HUMANS; IMMUNOPRECIPITATION; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN;

EID: 84864279057     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.05.034     Document Type: Article

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