Opposed arsenite-mediated regulation of p53-survivin is involved in neoplastic transformation, DNA damage, or apoptosis in human keratinocytes

Toxicology

Volumn 300, Issue 3, 2012, Pages 121-131

  Li, Yuan ^a,b   Jiang, Rongrong ^a,b   Zhao, Yue ^a,b   Xu, Yuan ^a,b   Ling, Min ^a,b   Pang, Ying ^a,b   Shen, Lu ^a,b   Zhou, Yun ^c   Zhang, Jianping ^c   Zhou, Jianwei ^b   Wang, Xinru ^b   Liu, Qizhan ^a,b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Nanjing Medical University   (China)

^c THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Biphasic dose response relationship; C Jun N terminal kinases (JNKs); Extracellular signal regulated kinases (ERKs); Nuclear factor B (NF B); P53; Survivin

Indexed keywords

ARSENIC TRIOXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN MDM2; PROTEIN P53; SURVIVIN;

APOPTOSIS; ARTICLE; BINDING KINETICS; CELL PROLIFERATION; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INHIBITION KINETICS; KERATINOCYTE; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR VOLUME; UPREGULATION;

ANIMALS; APOPTOSIS; ARSENITES; BLOTTING, SOUTHWESTERN; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL LINE; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOPRECIPITATION; INHIBITOR OF APOPTOSIS PROTEINS; KERATINOCYTES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, NUDE; MITOCHONDRIAL PROTEINS; NEOPLASMS; REAL-TIME POLYMERASE CHAIN REACTION; SODIUM COMPOUNDS; TUMOR SUPPRESSOR PROTEIN P53;

MURINAE;

EID: 84864062623     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.06.004     Document Type: Article

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