mot-2-mediated cross talk between nuclear factor-κb and p53 is involved in arsenite-induced tumorigenesis of human embryo lung fibroblast cells

Environmental Health Perspectives

Volumn 118, Issue 7, 2010, Pages 936-942

  Li, Yuan ^a   Xu, Yuan ^a   Ling, Min ^a   Yang, Ye ^a   Wang, Shoulin ^a   Li, Zhong ^a   Zhou, Jianwei ^a   Wang, Xinru ^a   Liu, Qizhan ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Arsenite; Mot 2; NF B; p53; Signal transduction; Tumorigenesis

Indexed keywords

ARSENIC TRIOXIDE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MEMBRANE PROTEIN; PROTEIN MOT 2; PROTEIN P53; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; ARSENOUS ACID DERIVATIVE; HEAT SHOCK PROTEIN 70; HSPA9 PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; LUNG CARCINOGENESIS; LUNG FIBROBLAST; MALIGNANT TRANSFORMATION; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEOMICS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR VOLUME; TWO DIMENSIONAL ELECTROPHORESIS; WESTERN BLOTTING; ANIMAL; ANIMAL EMBRYO; CELL LINE; CELL TRANSFORMATION; CHEMICALLY INDUCED; CYTOLOGY; DRUG EFFECTS; FIBROBLAST; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; NUDE MOUSE; PHYSIOLOGY; SIGNAL TRANSDUCTION; TOXICITY; TWO DIMENSIONAL GEL ELECTROPHORESIS;

ANIMALS; ARSENITES; BLOTTING, WESTERN; CELL LINE; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; EMBRYO, MAMMALIAN; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOPRECIPITATION; MICE; MICE, NUDE; NF-KAPPA B; PROTEOMICS; RECEPTOR CROSS-TALK; TUMOR SUPPRESSOR PROTEIN P53; MITOCHONDRIAL PROTEINS;

ANIMALIA; MUS MUSCULUS;

EID: 77954841387     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.0901677     Document Type: Article

References (37)

1. Aylon Y, Oren M. 2007. Living with p53, dying of p53. Cell 130(4):597-600.
2. Bodwell JE, Kingsley LA, Hamilton JW. 2004. Arsenic at very low concentrations alters glucocorticoid receptor (GR)-mediated gene activation but not GR-mediated gene repression: complex dose-response effects are closely correlated with levels of activated GR and require a functional GR DNA binding domain. Chem Res Toxicol 17(8):1064-1076.
3. Chen CL, Hsu LI, Chiou HY, Hsueh YM, Chen SY, Wu MM, et al. 2004. Ingested arsenic, cigarette smoking, and lung cancer risk: a follow-up study in arseniasis-endemic areas in Taiwan. JAMA 292(24):2984-2990.
4. Gao A, Liu B, Shi X, Jia X, Ye M, Jiao S, et al. 2007. Phosphatidylinositol-3 kinase/Akt/p70S6K/AP-1 signaling pathway mediated benzo(a)pyrene-induced cell cycle alternation via cell cycle regulatory proteins in human embryo lung fibroblasts. Toxicol Lett 170(1):30-41.
5. Hayflick L, Moorhead PS. 1961. The serial cultivation of human diploid cell strains. Exp Cell Res 25:585-621.
6. He XQ, Chen R, Yang P, Li AP, Zhou JW, Liu QZ. 2007. Biphasic effect of arsenite on cell proliferation and apoptosis is associated with the activation of JNK and ERK1/2 in human embryo lung fibroblast cells. Toxicol Appl Pharmacol 220(1):18-24.
7. Huang C, Ke Q, Costa M, Shi X. 2004. Molecular mechanisms of arsenic carcinogenesis. Mol Cell Biochem 255(1-2):57-66.
8. Huang WC, Ju TK, Hung MC, Chen CC. 2007. Phosphorylation of CBP by IKKa promotes cell growth by switching the binding preference of CBP from p53 to NF-kB. Mol Cell 26(1):75-87.
9. Huang Y, Zhang J, McHenry KT, Kim MM, Zeng W, Lopez-Pajares V, et al. 2008. Induction of cytoplasmic accumulation of p53: a mechanism for low levels of arsenic exposure to predispose cells for malignant transformation. Cancer Res 68(22):9131-9136.
10. IARC (International Agency for Research on Cancer). 2004. Some Drinking-water Disinfectants and Contaminants, including Arsenic. IARC Monogr Eval Carcinog Risks Hum 84:1-477.
11. Jiao S, Liu B, Gao A, Ye M, Jia X, Zhang F, et al. 2008. Benzo(a) pyrene-caused increased G1-S transition requires the activation of c-Jun through p53-dependent PI-3K/Akt/ERK pathway in human embryo lung fibroblasts. Toxicol Lett 178(3):167-175.
12. Kastan MB. 2007. Wild-type p53: tumors cant stand it. Cell 128(5):837-840.
13. Kaul SC, Aida S, Yaguchi T, Kaur K, Wadhwa R. 2005. Activation of wild type p53 function by its mortalin-binding, cytoplasmi-cally localizing carboxyl terminus peptides. J Biol Chem 280(47):39373-39379.
14. Kojima C, Qu W, Waalkes MP, Himeno S, Sakurai T. 2006. Chronic exposure to methylated arsenicals stimulates arsenic excretion pathways and induces arsenic tolerance in rat liver cells. Toxicol Sci 91(1):70-81.
15. Konstantakou EG, Voutsinas GE, Karkoulis PK, Aravantinos G, Margaritis LH, Stravopodis DJ. 2009. Human bladder cancer cells undergo cisplatin-induced apoptosis that is associated with p53-dependent and p53-independent responses. Int J Oncol 35(2):401-416.
16. Li JJ, Westergaard C, Ghosh P, Colburn NH. 1997. Inhibitors of both nuclear factor-kappaB and activator protein-1 activation block the neoplastic transformation response. Cancer Res 57(16):3569-3576.
17. Liao WT, Lin P, Cheng TS, Yu HS, Chang LW. 2007. Arsenic promotes centrosome abnormalities and cell colony formation in p53 compromised human lung cells. Toxicol Appl Pharmacol 225(2):162-170.
18. Lim DY, Park JH. 2009. Induction of p53 contributes to apopto-sis of HCT-116 human colon cancer cells induced by the dietary compound fisetin. Am J Physiol Gastrointest Liver Physiol 296(5):G1060-G1068.
19. Perkins ND. 2007. Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 8(1):49-62.
20. Pi J, Diwan BA, Sun Y, Liu J, Qu W, He Y, et al. 2008. Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2. Free Radic Biol Med 45(5):651-658.
21. Pi J, He Y, Bortner C, Huang J, Liu J, Zhou T, et al. 2005. Low level, long-term inorganic arsenite exposure causes generalized resistance to apoptosis in cultured human keratino-cytes: potential role in skin co-carcinogenesis. Int J Cancer 116(1):20-26.
22. Pi J, Yamauchi H, Kumagai Y, Sun G, Yoshida T, Aikawa H, et al. 2002. Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water. Environ Health Perspect 110:331-336.
23. Pietsch EC, Sykes SM, McMahon SB, Murphy ME. 2008. The p53 family and programmed cell death. Oncogene 27(50):6507-6521.
24. Sakurai T, Kojima C, Kobayashi Y, Hirano S, Sakurai MH, Waalkes MP, et al. 2006. Toxicity of a trivalent organic arsenic compound, dimethylarsinous glutathione in a rat liver cell line (TRL 1215). Br J Pharmacol 149(7):888-897.
25. Salnikow K, Zhitkovich A. 2008. Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium. Chem Res Toxicol 21(1):28-44.
26. Shen S, Lee J, Weinfeld M, Le XC. 2008. Attenuation of DNA damage-induced p53 expression by arsenic: a possible mechanism for arsenic co-carcinogenesis. Mol Carcinog 47(7):508-518.
27. Tapio S, Grosche B. 2006. Arsenic in the aetiology of cancer. Mutat Res 612(3):215-246.
28. Tokar EJ, Diwan BA, Waalkes MP. 2010. Arsenic exposure transforms human epithelial stem/progenitor cells into a cancer stem-like phenotype. Environ Health Perspect 118:108-115.
29. Wadhwa R, Taira K, Kaul SC. 2002. An Hsp70 family chaperone, mortalin/mthsp70/PBP74/Grp75: what, when, and where? Cell Stress Chaperones 7(3):309-316.
30. Wadhwa R, Takano S, Mitsui Y, Kaul SC. 1999. NIH 3T3 cells malignantly transformed by mot-2 show inactivation and cytoplasmic sequestration of the p53 protein. Cell Res 9(4):261-269.
31. Wang J, Ouyang W, Li J, Wei L, Ma Q, Zhang Z, et al. 2005. Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation. Cancer Res 65(15):6601-6611.
32. Webster GA, Perkins ND. 1999. Transcriptional cross talk between NF-kappaB and p53. Mol Cell Biol 19(5):3485-3495.
33. Wen G, Calaf GM, Partridge MA, Echiburu-Chau C, Zhao Y, Huang S, et al. 2008. Neoplastic transformation of human small airway epithelial cells induced by arsenic. Mol Med 14(1-2):2-10.
34. Wijeweera JB, Gandolfi AJ, Parrish A, Lantz RC. 2001. Sodium arsenite enhances AP-1 and NFkappaB DNA binding and induces stress protein expression in precision-cut rat lung slices. Toxicol Sci 61(2):283-294.
35. Wu R, Zhao YH, Plopper CG, Chang MM, Chmiel K, Cross JJ, et al. 1999. Differential expression of stress proteins in nonhuman primate lung and conducting airway after ozone exposure. Am J Physiol 277(31):L511-L522.
36. Yu X, Robinson JF, Gribble E, Hong SW, Sidhu JS, Faustman EM. 2008. Gene expression profiling analysis reveals arsenic-induced cell cycle arrest and apoptosis in p53-proficient and p53-deficient cells through differential gene pathways. Toxicol Appl Pharmacol 233(3):389-403.
37. Zhang J, Wu J, Huo R, Mao Y, Lu Y, Guo X, et al. 2007. ERp57 is a potential biomarker for human fertilization capability. Mol Hum Reprod 13(9):633-639.