DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen species

Chemical Research in Toxicology

Volumn 15, Issue 12, 2002, Pages 1627-1634

  Nesnow, Stephen ^a   Roop, Barbara C ^a   Lambert, Guy ^a   Kadiiska, Maria ^b   Mason, Ronald P ^b   Cullen, William R ^c   Mass, Marc J ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; ALPHA TOCOPHEROL DERIVATIVE; ARSENIC DERIVATIVE; DIMETHYLARSINOUS ACID; DNA; HYDROXYL RADICAL; MELATONIN; METHANEARSONIC ACID; REACTIVE OXYGEN METABOLITE; REACTIVE OXYGEN SPECIES INHIBITOR; TIRON; TROLOX C; UNCLASSIFIED DRUG;

ARSENIC POISONING; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL CARCINOGENESIS; CONCENTRATION RESPONSE; DNA DAMAGE; DNA METHYLATION; DNA SUPERCOILING; DRUG ACTIVITY; ELECTRON SPIN RESONANCE; GENOTOXICITY; INCUBATION TIME; INHIBITION KINETICS; MASS SPECTROMETRY; MOLECULAR PHYSICS; NICK END LABELING; OXIDATION; OXIDATIVE STRESS; PERIPHERAL LYMPHOCYTE; URINALYSIS;

ARSENIC; BACTERIOPHAGE PHI X 174; CACODYLIC ACID; CYCLIC N-OXIDES; DNA DAMAGE; DNA METHYLATION; DNA, SUPERHELICAL; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICAL SCAVENGERS; HUMANS; IN SITU NICK-END LABELING; ORGANOMETALLIC COMPOUNDS; REACTIVE OXYGEN SPECIES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TIME FACTORS;

TIRON;

EID: 0036908787     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx025598y     Document Type: Article

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