Hibris, a Drosophila Nephrin Homolog, Is Required for Presenilin-Mediated Notch and APP-like Cleavages

Developmental Cell

Volumn 23, Issue 1, 2012, Pages 82-96

  Singh, Jaskirat ^a   Mlodzik, Marek ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; DROSOPHILA PROTEIN; GAMMA SECRETASE; MUTANT PROTEIN; NEPHRIN; NOTCH RECEPTOR; PRESENILIN; PROTEIN HIBRIS; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DROSOPHILA; ENZYME REGULATION; EYE; FORELIMB; GENE INTERACTION; LARVA; MAMMAL CELL; MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENETIC ASSOCIATION STUDIES; MEMBRANE PROTEINS; MULTIGENE FAMILY; MULTIPROTEIN COMPLEXES; MUTAGENESIS; PEDIGREE; PRESENILINS; RECEPTORS, NOTCH;

MAMMALIA;

EID: 84864000903     PISSN: 15345807     EISSN: 18781551     Source Type: Journal    
DOI: 10.1016/j.devcel.2012.04.021     Document Type: Article

References (60)

1. Artavanis-Tsakonas S., Muskavitch M.A. Notch: the past, the present, and the future. Curr. Top. Dev. Biol. 2010, 92:1-29.
2. Artero R.D., Castanon I., Baylies M.K. The immunoglobulin-like protein Hibris functions as a dose-dependent regulator of myoblast fusion and is differentially controlled by Ras and Notch signaling. Development 2001, 128:4251-4264.
3. Bao S., Cagan R. Preferential adhesion mediated by Hibris and Roughest regulates morphogenesis and patterning in the Drosophila eye. Dev. Cell 2005, 8:925-935.
4. Boutros M., Paricio N., Strutt D.I., Mlodzik M. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 1998, 94:109-118.
5. Bray S., Musisi H., Bienz M. Bre1 is required for Notch signaling and histone modification. Dev. Cell 2005, 8:279-286.
6. Carmine-Simmen K., Proctor T., Tschäpe J., Poeck B., Triphan T., Strauss R., Kretzschmar D. Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function. Neurobiol. Dis. 2009, 33:274-281.
7. Chung H.M., Struhl G. Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila. Nat. Cell Biol. 2001, 3:1129-1132.
8. Cooper M.T., Bray S.J. Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye. Nature 1999, 397:526-530.
9. de Celis J.F., Garcia-Bellido A., Bray S.J. Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc. Development 1996, 122:359-369.
10. De Strooper B. Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex. Neuron 2003, 38:9-12.
11. De Strooper B., Annaert W. Novel research horizons for presenilins and γ-secretases in cell biology and disease. Annu. Rev. Cell Dev. Biol. 2010, 26:235-260.
12. De Strooper B., Annaert W., Cupers P., Saftig P., Craessaerts K., Mumm J.S., Schroeter E.H., Schrijvers V., Wolfe M.S., Ray W.J., et al. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 1999, 398:518-522.
13. De Strooper B., Saftig P., Craessaerts K., Vanderstichele H., Guhde G., Annaert W., Von Figura K., Van Leuven F. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 1998, 391:387-390.
14. del Alamo D., Mlodzik M. Frizzled/PCP-dependent asymmetric neuralized expression determines R3/R4 fates in the Drosophila eye. Dev. Cell 2006, 11:887-894.
15. Dworak H.A., Charles M.A., Pellerano L.B., Sink H. Characterization of Drosophila hibris, a gene related to human nephrin. Development 2001, 128:4265-4276.
16. Edbauer D., Winkler E., Regula J.T., Pesold B., Steiner H., Haass C. Reconstitution of gamma-secretase activity. Nat. Cell Biol. 2003, 5:486-488.
17. Fanto M., Mlodzik M. Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye. Nature 1999, 397:523-526.
18. Fehon R.G., Kooh P.J., Rebay I., Regan C.L., Xu T., Muskavitch M.A., Artavanis-Tsakonas S. Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell 1990, 61:523-534.
19. Fortini M.E. Notch signaling: the core pathway and its posttranslational regulation. Dev. Cell 2009, 16:633-647.
20. Fortini M.E., Artavanis-Tsakonas S. The suppressor of hairless protein participates in notch receptor signaling. Cell 1994, 79:273-282.
21. Fortini M.E., Rebay I., Caron L.A., Artavanis-Tsakonas S. An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye. Nature 1993, 365:555-557.
22. Goate A., Chartier-Harlin M.C., Mullan M., Brown J., Crawford F., Fidani L., Giuffra L., Haynes A., Irving N., James L., et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991, 349:704-706.
23. Hartmann D., de Strooper B., Serneels L., Craessaerts K., Herreman A., Annaert W., Umans L., Lübke T., Lena Illert A., von Figura K., Saftig P. The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum. Mol. Genet. 2002, 11:2615-2624.
24. Holzman L.B., St John P.L., Kovari I.A., Verma R., Holthofer H., Abrahamson D.R. Nephrin localizes to the slit pore of the glomerular epithelial cell. Kidney Int. 1999, 56:1481-1491.
25. Hu Y., Fortini M.E. Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex. J. Cell Biol. 2003, 161:685-690.
26. Hu Y., Ye Y., Fortini M.E. Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor. Dev. Cell 2002, 2:69-78.
27. Kallinen J., Heinonen S., Ryynänen M., Pulkkinen L., Mannermaa A. Antenatal genetic screening for congenital nephrosis. Prenat. Diagn. 2001, 21:81-84.
28. Kawachi H., Miyauchi N., Suzuki K., Han G.D., Orikasa M., Shimizu F. Role of podocyte slit diaphragm as a filtration barrier. Nephrology (Carlton) 2006, 11:274-281.
29. Kopan R., Ilagan M.X. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 2009, 137:216-233.
30. Koziell A., Grech V., Hussain S., Lee G., Lenkkeri U., Tryggvason K., Scambler P. Genotype/phenotype correlations of NPHS1 and NPHS2 mutations in nephrotic syndrome advocate a functional inter-relationship in glomerular filtration. Hum. Mol. Genet. 2002, 11:379-388.
31. Lai E.C., Orgogozo V. A hidden program in Drosophila peripheral neurogenesis revealed: fundamental principles underlying sensory organ diversity. Dev. Biol. 2004, 269:1-17.
32. Loewer A., Soba P., Beyreuther K., Paro R., Merdes G. Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development. EMBO Rep. 2004, 5:405-411.
33. López-Schier H., St Johnston D. Drosophila nicastrin is essential for the intramembranous cleavage of notch. Dev. Cell 2002, 2:79-89.
34. Mlodzik M. Planar polarity in the Drosophila eye: a multifaceted view of signaling specificity and cross-talk. EMBO J. 1999, 18:6873-6879.
35. Mumm J.S., Kopan R. Notch signaling: from the outside in. Dev. Biol. 2000, 228:151-165.
36. Muñoz-Soriano V., Belacortu Y., Durupt F.C., Muñoz-Descalzo S., Paricio N. Mtl interacts with members of Egfr signaling and cell adhesion genes in the Drosophila eye. Fly (Austin) 2011, 5:88-101.
37. Naruse S., Thinakaran G., Luo J.J., Kusiak J.W., Tomita T., Iwatsubo T., Qian X., Ginty D.D., Price D.L., Borchelt D.R., et al. Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron 1998, 21:1213-1221.
38. Nowotny P., Gorski S.M., Han S.W., Philips K., Ray W.J., Nowotny V., Jones C.J., Clark R.F., Cagan R.L., Goate A.M. Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin. Mol. Cell. Neurosci. 2000, 15:88-98.
39. Pan D., Rubin G.M. Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell 1997, 90:271-280.
40. Parks A.L., Cook K.R., Belvin M., Dompe N.A., Fawcett R., Huppert K., Tan L.R., Winter C.G., Bogart K.P., Deal J.E., et al. Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome. Nat. Genet. 2004, 36:288-292.
41. Ray W.J., Yao M., Nowotny P., Mumm J., Zhang W., Wu J.Y., Kopan R., Goate A.M. Evidence for a physical interaction between presenilin and Notch. Proc. Natl. Acad. Sci. USA 1999, 96:3263-3268.
42. Rosen D.R., Martin-Morris L., Luo L.Q., White K. A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor. Proc. Natl. Acad. Sci. USA 1989, 86:2478-2482.
43. Ruotsalainen V., Ljungberg P., Wartiovaara J., Lenkkeri U., Kestilä M., Jalanko H., Holmberg C., Tryggvason K. Nephrin is specifically located at the slit diaphragm of glomerular podocytes. Proc. Natl. Acad. Sci. USA 1999, 96:7962-7967.
44. Schroeter E.H., Kisslinger J.A., Kopan R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 1998, 393:382-386.
45. Selkoe D., Kopan R. Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annu. Rev. Neurosci. 2003, 26:565-597.
46. Shellenbarger D.L., Mohler J.D. Temperature-sensitive periods and autonomy of pleiotropic effects of l(1)Nts1, a conditional notch lethal in Drosophila. Dev. Biol. 1978, 62:432-446.
47. Shelton C., Kocherlakota K.S., Zhuang S., Abmayr S.M. The immunoglobulin superfamily member Hbs functions redundantly with Sns in interactions between founder and fusion-competent myoblasts. Development 2009, 136:1159-1168.
48. Sotillos S., Roch F., Campuzano S. The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs. Development 1997, 124:4769-4779.
49. Stempfle D., Kanwar R., Loewer A., Fortini M.E., Merdes G. In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity. Mol. Cell. Biol. 2010, 30:3165-3175.
50. Struhl G., Adachi A. Nuclear access and action of notch in vivo. Cell 1998, 93:649-660.
51. Struhl G., Greenwald I. Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 1999, 398:522-525.
52. Strutt H., Strutt D. Polarity determination in the Drosophila eye. Curr. Opin. Genet. Dev. 1999, 9:442-446.
53. Thinakaran G., Borchelt D.R., Lee M.K., Slunt H.H., Spitzer L., Kim G., Ratovitsky T., Davenport F., Nordstedt C., Seeger M., et al. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 1996, 17:181-190.
54. Thinakaran G., Koo E.H. Amyloid precursor protein trafficking, processing, and function. J. Biol. Chem. 2008, 283:29615-29619.
55. Tomlinson A., Struhl G. Decoding vectorial information from a gradient: sequential roles of the receptors Frizzled and Notch in establishing planar polarity in the Drosophila eye. Development 1999, 126:5725-5738.
56. Wagner N., Morrison H., Pagnotta S., Michiels J.F., Schwab Y., Tryggvason K., Schedl A., Wagner K.D. The podocyte protein nephrin is required for cardiac vessel formation. Hum. Mol. Genet. 2011, 20:2182-2194.
57. Wen C., Metzstein M.M., Greenwald I. SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling. Development 1997, 124:4759-4767.
58. Ye Y., Fortini M.E. Characterization of Drosophila Presenilin and its colocalization with Notch during development. Mech. Dev. 1998, 79:199-211.
59. Ye Y., Fortini M.E. Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster. J. Cell Biol. 1999, 146:1351-1364.
60. Zheng L., Zhang J., Carthew R.W. frizzled regulates mirror-symmetric pattern formation in the Drosophila eye. Development 1995, 121:3045-3055.