Polarity determination in the Drosophila eye

Current Opinion in Genetics and Development

Volumn 9, Issue 4, 1999, Pages 442-446

  Strutt, Helen ^a   Strutt, David ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

DEVELOPMENTAL GENETICS; DROSOPHILA; EMBRYO POLARITY; EYE DEVELOPMENT; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; SHORT SURVEY; SIGNAL TRANSDUCTION;

INSECTA;

EID: 0033523280     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(99)80067-7     Document Type: Article

References (22)

1. Ready DF, Hanson TE, Benzer S: Development of the Drosophila retina, a neurocrystalline lattice. Dev Biol 1976, 53:217-240.
2. Zheng L, Zhang J, Carthew RW: Frizzled regulates mirror-symmetric pattern formation in the Drosophila eye. Development 1995, 121:3045-3055.
3. Vinson CR, Conover S, Adler PN: A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains. Nature 1989, 338:263-264.
4. Vinson CR, Adler PN: Directional non-cell autonomy and the transmission of polarity information by the frizzled gene of Drosophila. Nature 1987, 329:549-551.
5. Krasnow RE, Wong LL, Adler PN: Dishevelled is a component of the frizzled signaling pathway in Drosophila. Development 1995, 121:4095-4102.
6. Strutt DI, Weber U, Mlodzik M: The role of RhoA in tissue polarity and Frizzled signalling. Nature 1997, 387:292-295.
7. Shulman JM, Perrimon N, Axelrod JD: Frizzled signaling and the developmental control of cell polarity. Trends Genet 1998, 14:452-458.
8. Boutros M, Paricio N, Strutt DI, Mlodzik M: Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 1998, 94:109-118. JNK signal transduction cascades are shown to act downstream of Dishevelled during Frizzled signalling. In addition, this study shows that a particular domain of the Dishevelled protein (the DEP domain) is required for polarity signalling downstream of Frizzled. Conversely, the PDZ domain of Dishevelled - previously shown to be required for Wingless signalling - is found to be dispensable for polarity signalling.
9. Axelrod JD, Miller JR, Shulman JM, Moon RT, Perrimon N: Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. Genes Dev 1998, 12:2610-2622. The authors show that distinct domains of Dishevelled are required for its function in planar polarity signalling and in Wingless signalling. The DEP domain of Dishevelled is dispensible for Wingless signalling but is required for the recruitment of Dishevelled to the cell membrane to mediate Frizzled signal transduction.
10. Klingensmith J, Nusse R, Perrimon N: The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. Genes Dev 1994, 8:118-130.
11. Gubb D: Cellular polarity, mitotic synchrony and axes of symmetry during growth. Where does the information come from? Int J Dev Biol 1998, 42:369-377.
12. Wolff T, Rubin G: Strabismus, a novel gene that regulates tissue polarity and cell fate decisions in Drosophila. Development 1998, 125:1149-1159.
13. Wehrli M, Tomlinson A: Independent regulation of anterior/posterior and equatorial/polar polarity in the Drosophila eye; evidence for the involvement of Wnt signaling in the equatorial/polar axis. Development 1998, 125:1421-1432. This report presents evidence that a gradient of Wingless from the dorsal and ventral poles of the eye disc regulates ommatidial polarity decisions. A model is presented that explains the observed phenotypes by postulating that Wingless signalling regulates the secretion of an unidentified downstream secreted factor, the gradient of which determines ommatidial polarity.
14. Zeidler M, Perrimon N, Strutt DI: Polarity determination in the Drosophila eye: A novel role for Unpaired and JAK/STAT signalling. Genes Dev 1999, 13:1342-1352. This paper shows that there is a gradient of JAK/STAT signalling activity across the dorso-ventral axis of the eye disc, at least partly regulated by the localised secretion of the ligand Unpaired at the posterior midline. This gradient of JAK/STAT activity is shown to be a determinant of ommatidial polarity on the dorso-ventral axis, possibly acting antagonistically to Wingless in the regulation of an unidentified downstream secreted factor.
15. Papayannopoulos V, Tomlinson A, Panin VM, Rauskolb C, Irvine KD: Dorsal-ventral signaling in the Drosophila eye. Science 1998, 281:2031-2034. See annotation [17•].
16. Cho K-O, Choi K-W: Fringe is essential for mirror symmetry and morphogenesis in the Drosophila eye. Nature 1998, 396:272-276. See annotation [17•].
17. Domínguez M, de Celis JF: A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye. Nature 1998, 396:276-278. These three reports [15•-17•] show that localised expression of the fringe gene in the ventral half of the eye disc leads to the activation of Notch at the equator. This activation of Notch is shown to be important in locally organising ommatidial polarity and promoting growth of the eye disc.
18. McNeill H, Yang CH, Brodsky M, Ungos J, Simon MA: Mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye. Genes Dev 1997, 11:1073-1082.
19. Heberlein U, Borod E, Chanut F: Dorsoventral patterning in the Drosophila retina by wingless. Development 1998, 125:567-577.
20. Cooper MY, Bray SJ: Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye. Nature 1999, 397:526-530. See annotation [21•].
21. Fanto M, Mlodzik M: Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye. Nature 1999, 397:523-526. These two papers [20•,21•] present evidence that Notch and Delta function downstream of Frizzled. It is shown that Delta expression is upregulated by Frizzled signalling in the R3 cell whereas the R4 cell shows increased activation of Notch, and that activation of Notch downregulates Delta. This suggests that Notch-Delta signalling amplifies the initial small difference in Frizzled signalling between the R3 and R4 cell, and enables them to make a binary cell-fate decision.
22. Parks AL, Turner R, Muskavitch MAT: Relationships between complex Delta expression and the specification of retinal cell fates during Drosophila eye development. Mech Dev 1995, 50:201-216.