Synthesis and evaluation of a new series of Tri-, Di-, and mono- n -alkylcarbamylphloroglucinols as bulky inhibitors of acetylcholinesterase

Chemical Research in Toxicology

Volumn 25, Issue 7, 2012, Pages 1462-1471

  Lin, Ming Chen ^a   Lin, Gin Zen ^b   Shen, Yu Fong ^b,c   Jian, Shuo Yung ^b   Hsieh, Dean Kuo ^d   Lin, James ^e   Lin, Gialih ^b,d  

^a CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^d CHAOYANG UNIVERSITY OF TECHNOLOGY   (Taiwan)

^e NATIONAL TAIWAN OCEAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

,5 DI N N ALKYLCARBAMYLOXYPHENOL DERIVATIVE; 1,3,5 TRI N ALKYLCARBAMYLPHLOROGLUCINOL DERIVARIVE; 1,3,5 TRI N N BUTYLCARBAMYLPHLOROGLUCINOL; 1,3,5 TRI N N HEPTYLCARBAMYLPHLOROGLUCINOL; 1,3,5 TRI N N HEXYLCARBAMYLPHLOROGLUCINOL; 1,3,5 TRI N N OCTYLCARBAMYLPHLOROGLUCINOL; 3,5 DI N N BUTYLCARBAMYLOXYPHENOL; 3,5 DI N N HEPTYLCARBAMYLOXYPHENOL; 3,5 DI N N HEXYLCARBAMYLOXYPHENOL; 3,5 DI N N OCTYLCARBAMYLOXYPHENOL; 5 N N ALKYLCARBAMYLOXYRESORCINOL DERIVATIVE; 5 N N BUTYLCARBAMYLOXYRESORCINOL; 5 N N HEPTYLCARBAMYLOXYRESORCINOL; 5 N N HEXYLCARBAMYLOXYRESORCINOL; 5 N N OCTYLCARBAMYLOXYRESORCINOL; CHOLINESTERASE INHIBITOR; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME BINDING; MOLECULAR DOCKING;

ACETYLCHOLINESTERASE; ANIMALS; BINDING SITES; BIOCATALYSIS; CARBAMATES; CHOLINESTERASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; ISOMERISM; MICE; PHLOROGLUCINOL; PROTEIN STRUCTURE, TERTIARY;

EID: 84863923099     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx300119a     Document Type: Article

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