-
1
-
-
0035320772
-
Acetylcholinesterase - New roles for an old actor
-
Soreq H Seidman S (2001) Acetylcholinesterase - new roles for an old actor. Nat Rev Neurosci 2, 294 302.
-
(2001)
Nat Rev Neurosci
, vol.2
, pp. 294-302
-
-
Soreq, H.1
Seidman, S.2
-
2
-
-
0027535179
-
Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins
-
Cygler M, Schrag JD, Sussman JL, Harel M, Silman I, Gentry MK Doctor BP (1993) Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins. Protein Sci 2, 366 382.
-
(1993)
Protein Sci
, vol.2
, pp. 366-382
-
-
Cygler, M.1
Schrag, J.D.2
Sussman, J.L.3
Harel, M.4
Silman, I.5
Gentry, M.K.6
Doctor, B.P.7
-
3
-
-
0032784276
-
α/β Hydrolase fold enzymes: The family keeps growing
-
Nardini M Dijkstra BW (1999) α/β Hydrolase fold enzymes: the family keeps growing. Curr Opin Struct Biol 9, 732 737.
-
(1999)
Curr Opin Struct Biol
, vol.9
, pp. 732-737
-
-
Nardini, M.1
Dijkstra, B.W.2
-
4
-
-
33845282579
-
Acetylcholinesterase: Enzyme structure, reaction dynamics, and virtual transition states
-
Quinn DM (1987) Acetylcholinesterase: enzyme structure, reaction dynamics, and virtual transition states. Chem Rev 87, 955 979.
-
(1987)
Chem Rev
, vol.87
, pp. 955-979
-
-
Quinn, D.M.1
-
5
-
-
0001753330
-
Acetylcholinesterase: Enthalpies and entropies of activation
-
Wilson IB Cabib E (1956) Acetylcholinesterase: enthalpies and entropies of activation. J Am Chem Soc 78, 202 207.
-
(1956)
J Am Chem Soc
, vol.78
, pp. 202-207
-
-
Wilson, I.B.1
Cabib, E.2
-
6
-
-
0033063504
-
A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase
-
Silman I, Millard CB, Ordentlich A, Greenblatt HM, Harel M, Barak D, Schafferman A Sussman JL (1999) A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase. Chem Biol Interact 119-120, 43 52.
-
(1999)
Chem Biol Interact
, vol.119-120
, pp. 43-52
-
-
Silman, I.1
Millard, C.B.2
Ordentlich, A.3
Greenblatt, H.M.4
Harel, M.5
Barak, D.6
Schafferman, A.7
Sussman, J.L.8
-
7
-
-
33749402097
-
Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding
-
Bourne Y, Radić Z, Sulzenbacher G, Kim E, Taylor P Marchot P (2006) Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding. J Biol Chem 281, 29256 29267.
-
(2006)
J Biol Chem
, vol.281
, pp. 29256-29267
-
-
Bourne, Y.1
Radić, Z.2
Sulzenbacher, G.3
Kim, E.4
Taylor, P.5
Marchot, P.6
-
8
-
-
0025778840
-
Atomic structure of acetylcholinesterase from Torpedo californica: A prototypic acetylcholine-binding protein
-
Sussman JL, Harel M, Frolow F, Oefner C, Goldman A, Toker L Silman I (1991) Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein. Science 253, 872 879.
-
(1991)
Science
, vol.253
, pp. 872-879
-
-
Sussman, J.L.1
Harel, M.2
Frolow, F.3
Oefner, C.4
Goldman, A.5
Toker, L.6
Silman, I.7
-
9
-
-
18744414554
-
Acetylcholinesterase: 'Classical' and 'non-classical' functions and pharmacology
-
Silman I Sussman JL (2005) Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology. Curr Opin Pharmacol 5, 293 302.
-
(2005)
Curr Opin Pharmacol
, vol.5
, pp. 293-302
-
-
Silman, I.1
Sussman, J.L.2
-
10
-
-
0027368530
-
Quaternary ligand binding to aromatic residues in the active site gorge of acetylcholinesterase
-
Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I Sussman JL (1993) Quaternary ligand binding to aromatic residues in the active site gorge of acetylcholinesterase. Proc Natl Acad Sci USA 90, 9031 9035.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 9031-9035
-
-
Harel, M.1
Schalk, I.2
Ehret-Sabatier, L.3
Bouet, F.4
Goeldner, M.5
Hirth, C.6
Axelsen, P.H.7
Silman, I.8
Sussman, J.L.9
-
11
-
-
0027217179
-
Dissection of the human acetylcholinesterase active center determinants of substrate specificity
-
Ordentlich A, Kronman C, Flashner Y, Leitner M, Segall Y, Ariel N, Cohen S, Velan B Shafferman A (1993) Dissection of the human acetylcholinesterase active center determinants of substrate specificity. J Biol Chem 268, 17083 17095.
-
(1993)
J Biol Chem
, vol.268
, pp. 17083-17095
-
-
Ordentlich, A.1
Kronman, C.2
Flashner, Y.3
Leitner, M.4
Segall, Y.5
Ariel, N.6
Cohen, S.7
Velan, B.8
Shafferman, A.9
-
12
-
-
33745550034
-
Structural insights into substrate traffic and inhibition in acetylcholinesterase
-
Colletier JP, Fournier D, Greenblatt HM, Stojan J, Sussman JL, Zaccai G, Silman I Weik M (2006) Structural insights into substrate traffic and inhibition in acetylcholinesterase. EMBO J 25, 2746 2756.
-
(2006)
EMBO J
, vol.25
, pp. 2746-2756
-
-
Colletier, J.P.1
Fournier, D.2
Greenblatt, H.M.3
Stojan, J.4
Sussman, J.L.5
Zaccai, G.6
Silman, I.7
Weik, M.8
-
13
-
-
0026733022
-
Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding
-
Shafferman A, Kronman C, Flashner Y, Leitner M, Grosfeld H, Ordentlich A, Gozes Y, Cohen S, Ariel A, Barak D et al. (1992) Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding. J Biol Chem 267, 17640 17648.
-
(1992)
J Biol Chem
, vol.267
, pp. 17640-17648
-
-
Shafferman, A.1
Kronman, C.2
Flashner, Y.3
Leitner, M.4
Grosfeld, H.5
Ordentlich, A.6
Gozes, Y.7
Cohen, S.8
Ariel, A.9
Barak, D.10
-
14
-
-
0027517144
-
Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors
-
Radić Z, Pickering NA, Vellom DC, Camp S Taylor P (1993) Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors. Biochemistry 32, 12074 12084.
-
(1993)
Biochemistry
, vol.32
, pp. 12074-12084
-
-
Radić, Z.1
Pickering, N.A.2
Vellom, D.C.3
Camp, S.4
Taylor, P.5
-
15
-
-
0028246856
-
Site of fasciculin interaction with acetylcholinesterase
-
Radić Z, Duran R, Vellom DC, Li Y, Cervenansky C Taylor P (1994) Site of fasciculin interaction with acetylcholinesterase. J Biol Chem 269, 11233 11239.
-
(1994)
J Biol Chem
, vol.269
, pp. 11233-11239
-
-
Radić, Z.1
Duran, R.2
Vellom, D.C.3
Li, Y.4
Cervenansky, C.5
Taylor, P.6
-
16
-
-
0028270692
-
Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core
-
Barak D, Kronman C, Ordentlich A, Ariel N, Bromberg A, Marcus D, Lazar A, Velan B Shafferman A (1994) Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core. J Biol Chem 269, 6296 6305.
-
(1994)
J Biol Chem
, vol.269
, pp. 6296-6305
-
-
Barak, D.1
Kronman, C.2
Ordentlich, A.3
Ariel, N.4
Bromberg, A.5
Marcus, D.6
Lazar, A.7
Velan, B.8
Shafferman, A.9
-
17
-
-
0028955778
-
Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase
-
Ordentlich A, Barak D, Kronman C, Ariel N, Segall Y, Velan B Shafferman A (1995) Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase. J Biol Chem 270, 2082 2091.
-
(1995)
J Biol Chem
, vol.270
, pp. 2082-2091
-
-
Ordentlich, A.1
Barak, D.2
Kronman, C.3
Ariel, N.4
Segall, Y.5
Velan, B.6
Shafferman, A.7
-
18
-
-
0029781839
-
Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates
-
Hosea NA, Radić Z, Tsigelny I, Berman HA, Quinn DM Taylor P (1996) Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates. Biochemistry 35, 10995 11004.
-
(1996)
Biochemistry
, vol.35
, pp. 10995-11004
-
-
Hosea, N.A.1
Radić, Z.2
Tsigelny, I.3
Berman, H.A.4
Quinn, D.M.5
Taylor, P.6
-
19
-
-
0033524414
-
Substrate binding to the peripheral site of acetylcholinesterase initiates enzymatic catalysis. Substrate inhibition arises as a secondary effect
-
Szegletes T, Mallender WD, Thomas PJ Rosenberry TL (1999) Substrate binding to the peripheral site of acetylcholinesterase initiates enzymatic catalysis. Substrate inhibition arises as a secondary effect. Biochemistry 38, 122 133.
-
(1999)
Biochemistry
, vol.38
, pp. 122-133
-
-
Szegletes, T.1
Mallender, W.D.2
Thomas, P.J.3
Rosenberry, T.L.4
-
20
-
-
0034604236
-
Acetylcholine binds to Asp74 at the peripheral site of human acetylcholinesterase as the first step in the catalytic pathway
-
Mallender WD, Szegletes T Rosenberry TL (2000) Acetylcholine binds to Asp74 at the peripheral site of human acetylcholinesterase as the first step in the catalytic pathway. Biochemistry 39, 7753 7763.
-
(2000)
Biochemistry
, vol.39
, pp. 7753-7763
-
-
Mallender, W.D.1
Szegletes, T.2
Rosenberry, T.L.3
-
21
-
-
33644867844
-
The peripheral anionic site of acetylcholinesterase: Structure, functions and potential role in rational drug design
-
Johnson G Moore SW (2006) The peripheral anionic site of acetylcholinesterase: structure, functions and potential role in rational drug design. Curr Pharm Des 12, 217 225.
-
(2006)
Curr Pharm des
, vol.12
, pp. 217-225
-
-
Johnson, G.1
Moore, S.W.2
-
22
-
-
1942520265
-
Inhibition of Drosophila melanogaster acetylcholinesterase by high concentrations of substrate
-
Stojan J, Brochier L, Alies C, Colletier JP Fournier D (2004) Inhibition of Drosophila melanogaster acetylcholinesterase by high concentrations of substrate. Eur J Biochem 271, 1364 1371.
-
(2004)
Eur J Biochem
, vol.271
, pp. 1364-1371
-
-
Stojan, J.1
Brochier, L.2
Alies, C.3
Colletier, J.P.4
Fournier, D.5
-
23
-
-
0036560908
-
The origin of the molecular diversity and functional anchoring of cholinesterases
-
Massoulié J (2002) The origin of the molecular diversity and functional anchoring of cholinesterases. Neurosignals 11, 130 143.
-
(2002)
Neurosignals
, vol.11
, pp. 130-143
-
-
Massoulié, J.1
-
24
-
-
4544318524
-
Molecular modelling approaches to the design of acetylcholinesterase inhibitors: New challenges for the treatment of Alzheimer's disease
-
Muñoz-Muriedas J, Lopez JM, Orozco M Luque FJ (2004) Molecular modelling approaches to the design of acetylcholinesterase inhibitors: new challenges for the treatment of Alzheimer's disease. Curr Pharm Des 10, 3131 3140.
-
(2004)
Curr Pharm des
, vol.10
, pp. 3131-3140
-
-
Muñoz-Muriedas, J.1
Lopez, J.M.2
Orozco, M.3
Luque, F.J.4
-
25
-
-
0027198071
-
Cholinesterases regulate neurite growth of chick nerve cells in vitro by means of a non-enzymatic mechanism
-
Layer PG, Weikert T Alber R (1993) Cholinesterases regulate neurite growth of chick nerve cells in vitro by means of a non-enzymatic mechanism. Cell Tissue Res 273, 219 226.
-
(1993)
Cell Tissue Res
, vol.273
, pp. 219-226
-
-
Layer, P.G.1
Weikert, T.2
Alber, R.3
-
26
-
-
0033568704
-
Structural roles of acetylcholinesterase variants in biology and pathology
-
Grisaru D, Sternfeld M, Eldor A, Glick D Soreq H (1999) Structural roles of acetylcholinesterase variants in biology and pathology. Eur J Biochem 264, 672 686.
-
(1999)
Eur J Biochem
, vol.264
, pp. 672-686
-
-
Grisaru, D.1
Sternfeld, M.2
Eldor, A.3
Glick, D.4
Soreq, H.5
-
27
-
-
0037298750
-
Beta-amyloid aggregation induced by human acetylcholinesterase: Inhibition studies
-
Bartolini M, Bertucci C, Cavrini V Andrisano V (2003) Beta-amyloid aggregation induced by human acetylcholinesterase: inhibition studies. Biochem Pharmacol 65, 407 416.
-
(2003)
Biochem Pharmacol
, vol.65
, pp. 407-416
-
-
Bartolini, M.1
Bertucci, C.2
Cavrini, V.3
Andrisano, V.4
-
28
-
-
0031587286
-
Acetylcholinesterase promotes the aggregation of amyloid-β-peptide fragments by forming a complex with the growing fibrils
-
Alvarez A, Opazo C, Alarcon R, Garrido J Inestrosa NC (1997) Acetylcholinesterase promotes the aggregation of amyloid-β-peptide fragments by forming a complex with the growing fibrils. J Mol Biol 272, 348 361.
-
(1997)
J Mol Biol
, vol.272
, pp. 348-361
-
-
Alvarez, A.1
Opazo, C.2
Alarcon, R.3
Garrido, J.4
Inestrosa, N.C.5
-
29
-
-
0038618612
-
Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex
-
Rees T, Hammond PI, Soreq H, Younkin S Brimijoin S (2003) Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex. Neurobiol Aging 24, 777 787.
-
(2003)
Neurobiol Aging
, vol.24
, pp. 777-787
-
-
Rees, T.1
Hammond, P.I.2
Soreq, H.3
Younkin, S.4
Brimijoin, S.5
-
30
-
-
0141642240
-
Acetylcholinesterase induces neuronal cell loss, astrocyte hypertrophy and behavioral deficits in mammalian hippocampus
-
Chacón MA, Reyes AE Inestrosa NC (2003) Acetylcholinesterase induces neuronal cell loss, astrocyte hypertrophy and behavioral deficits in mammalian hippocampus. J Neurochem 87, 195 204.
-
(2003)
J Neurochem
, vol.87
, pp. 195-204
-
-
Chacón, M.A.1
Reyes, A.E.2
Inestrosa, N.C.3
-
31
-
-
0032080309
-
Stable complexes involving acetylcholinesterase and amyloid-β peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils
-
Alvarez A, Alarcon R, Opazo C, Campos EO, Munoz FJ, Calderon FH, Dajas F, Gentry MK, Doctor BP, De Mello FG et al. (1998) Stable complexes involving acetylcholinesterase and amyloid-β peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils. J Neurosci 18, 3213 3223.
-
(1998)
J Neurosci
, vol.18
, pp. 3213-3223
-
-
Alvarez, A.1
Alarcon, R.2
Opazo, C.3
Campos, E.O.4
Munoz, F.J.5
Calderon, F.H.6
Dajas, F.7
Gentry, M.K.8
Doctor, B.P.9
De Mello, F.G.10
-
32
-
-
2442647903
-
Acetylcholinesterase-Aβ complexes are more toxic than Aβ fibrils in rat hippocampus
-
Reyes AE, Chacón MA, Dinamarca MC, Cerpa W, Morgan C Inestrosa NC (2004) Acetylcholinesterase-Aβ complexes are more toxic than Aβ fibrils in rat hippocampus. Am J Pathol 164, 2163 2174.
-
(2004)
Am J Pathol
, vol.164
, pp. 2163-2174
-
-
Reyes, A.E.1
Chacón, M.A.2
Dinamarca, M.C.3
Cerpa, W.4
Morgan, C.5
Inestrosa, N.C.6
-
33
-
-
38549098085
-
Amyloid-cholinesterase interactions. Implications for Alzheimer's disease
-
Inestrosa NC, Dinamarca MC Alvarez A (2008) Amyloid-cholinesterase interactions. Implications for Alzheimer's disease. FEBS J 275, 625 632.
-
(2008)
FEBS J
, vol.275
, pp. 625-632
-
-
Inestrosa, N.C.1
Dinamarca, M.C.2
Alvarez, A.3
-
34
-
-
0025970008
-
Electron microscopic localization of cholinesterase activity in Alzheimer brain tissue
-
Carson KA, Geula C Mesulam MM (1991) Electron microscopic localization of cholinesterase activity in Alzheimer brain tissue. Brain Res 540, 204 208.
-
(1991)
Brain Res
, vol.540
, pp. 204-208
-
-
Carson, K.A.1
Geula, C.2
Mesulam, M.M.3
-
35
-
-
0027475810
-
Protease inhibitors and indoleamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer disease
-
Wright CI, Geula C Mesulam MM (1993) Protease inhibitors and indoleamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer disease. Proc Natl Acad Sci USA 90, 683 686.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 683-686
-
-
Wright, C.I.1
Geula, C.2
Mesulam, M.M.3
-
36
-
-
0032440687
-
Molecular interactions of acetylcholinesterase with senile plaques
-
Inestrosa NC Alarcon R (1998) Molecular interactions of acetylcholinesterase with senile plaques. J Physiol (Paris) 92, 341 344.
-
(1998)
J Physiol (Paris)
, vol.92
, pp. 341-344
-
-
Inestrosa, N.C.1
Alarcon, R.2
-
37
-
-
4544236922
-
Acetylcholinesterase inhibitors as a starting point towards improved Alzheimer's disease therapeutics
-
Recanatini M Valenti P (2004) Acetylcholinesterase inhibitors as a starting point towards improved Alzheimer's disease therapeutics. Curr Pharm Des 10, 3157 3166.
-
(2004)
Curr Pharm des
, vol.10
, pp. 3157-3166
-
-
Recanatini, M.1
Valenti, P.2
-
38
-
-
35748978820
-
Recent developments in cholinesterase inhibitors for Alzheimer's disease treatment
-
Musiał A, Bajda M Malawska B (2007) Recent developments in cholinesterase inhibitors for Alzheimer's disease treatment. Curr Med Chem 14, 2654 2679.
-
(2007)
Curr Med Chem
, vol.14
, pp. 2654-2679
-
-
Musiał, A.1
Bajda, M.2
Malawska, B.3
-
39
-
-
0032478778
-
Is there a rationale for the use of acetylcholinesterase inhibitors in the therapy of Alzheimer's disease?
-
Benzi G Moretti A (1998) Is there a rationale for the use of acetylcholinesterase inhibitors in the therapy of Alzheimer's disease? Eur J Pharmacol 346, 1 13.
-
(1998)
Eur J Pharmacol
, vol.346
, pp. 1-13
-
-
Benzi, G.1
Moretti, A.2
-
40
-
-
4544291755
-
An overview of the current and novel drugs for Alzheimer's disease with particular reference to anti-cholinesterase compounds
-
Colombres M, Sagal JP Inestrosa NC (2004) An overview of the current and novel drugs for Alzheimer's disease with particular reference to anti-cholinesterase compounds. Curr Pharm Des 10, 3121 3130.
-
(2004)
Curr Pharm des
, vol.10
, pp. 3121-3130
-
-
Colombres, M.1
Sagal, J.P.2
Inestrosa, N.C.3
-
41
-
-
0037413712
-
Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site
-
Bourne Y, Taylor P, Radić Z Marchot P (2003) Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site. EMBO J 22, 1 12.
-
(2003)
EMBO J
, vol.22
, pp. 1-12
-
-
Bourne, Y.1
Taylor, P.2
Radić, Z.3
Marchot, P.4
-
42
-
-
12444257779
-
3-(4-l[Benzyl(methyl)amino]methylrphenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation: A dual function lead for Alzheimer's disease therapy
-
Piazzi L, Rampa A, Bisi A, Gobbi S, Belluti F, Cavalli A, Bartolini M, Andrisano V, Valenti P Recanatini M (2003) 3-(4-l[Benzyl(methyl)amino] methylrphenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation: a dual function lead for Alzheimer's disease therapy. J Med Chem 46, 2279 2282.
-
(2003)
J Med Chem
, vol.46
, pp. 2279-2282
-
-
Piazzi, L.1
Rampa, A.2
Bisi, A.3
Gobbi, S.4
Belluti, F.5
Cavalli, A.6
Bartolini, M.7
Andrisano, V.8
Valenti, P.9
Recanatini, M.10
-
43
-
-
0033103478
-
Structure of acetylcholinesterase complexed with E2020 (Aricept): Implications for the design of new anti-Alzheimer drugs
-
Kryger G, Silman I Sussman JL (1999) Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Struct Fold Des 7, 297 307.
-
(1999)
Struct Fold des
, vol.7
, pp. 297-307
-
-
Kryger, G.1
Silman, I.2
Sussman, J.L.3
-
44
-
-
29844436355
-
Synthesis of tricyclic 1,3-oxazin-4-ones and kinetic analysis of cholesterol esterase and acetylcholinesterase inhibition
-
Pietsch M Gütschow M (2005) Synthesis of tricyclic 1,3-oxazin-4-ones and kinetic analysis of cholesterol esterase and acetylcholinesterase inhibition. J Med Chem 48, 8270 8288.
-
(2005)
J Med Chem
, vol.48
, pp. 8270-8288
-
-
Pietsch, M.1
Gütschow, M.2
-
45
-
-
0017697779
-
Catalysis by acetylcholinesterase. Acceleration of the hydrolysis of neutral acetic acid esters by certain aromatic cations
-
Barnett P Rosenberry TL (1977) Catalysis by acetylcholinesterase. Acceleration of the hydrolysis of neutral acetic acid esters by certain aromatic cations. J Biol Chem 252, 7200 7206.
-
(1977)
J Biol Chem
, vol.252
, pp. 7200-7206
-
-
Barnett, P.1
Rosenberry, T.L.2
-
46
-
-
0000140355
-
Nonequilibrium analysis alters the mechanistic interpretation of inhibition of acetylcholinesterase by peripheral site ligands
-
Szegletes T, Mallender WD Rosenberry TL (1998) Nonequilibrium analysis alters the mechanistic interpretation of inhibition of acetylcholinesterase by peripheral site ligands. Biochemistry 37, 4206 4216.
-
(1998)
Biochemistry
, vol.37
, pp. 4206-4216
-
-
Szegletes, T.1
Mallender, W.D.2
Rosenberry, T.L.3
-
47
-
-
0343134441
-
Molecular mechanisms for hydrolytic enzyme action. III. A general mechanism for the inhibition of acetylcholinesterase
-
Krupka RM Laidler KJ (1961) Molecular mechanisms for hydrolytic enzyme action. III. A general mechanism for the inhibition of acetylcholinesterase. J Am Chem Soc 83, 1454 1458.
-
(1961)
J Am Chem Soc
, vol.83
, pp. 1454-1458
-
-
Krupka, R.M.1
Laidler, K.J.2
-
48
-
-
37049153631
-
Analytical description of the effects of modifiers and of enzyme multivalency upon the steady state catalyzed reaction rate
-
Botts J Morales M (1953) Analytical description of the effects of modifiers and of enzyme multivalency upon the steady state catalyzed reaction rate. Trans Faraday Soc 49, 696 707.
-
(1953)
Trans Faraday Soc
, vol.49
, pp. 696-707
-
-
Botts, J.1
Morales, M.2
-
49
-
-
0003518480
-
-
Wiley and Sons, New York, NY.
-
Segel IH (1993) Enzyme Kinetics. Wiley and Sons, New York, NY.
-
(1993)
Enzyme Kinetics.
-
-
Segel, I.H.1
-
52
-
-
33845480947
-
Novel heterobivalent tacrine derivatives as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase
-
Elsinghorst PW, González Tanarro CM Gütschow M (2006) Novel heterobivalent tacrine derivatives as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase. J Med Chem 49, 7540 7544.
-
(2006)
J Med Chem
, vol.49
, pp. 7540-7544
-
-
Elsinghorst, P.W.1
González Tanarro, C.M.2
Gütschow, M.3
-
53
-
-
0033379073
-
Molecular recognition by acetylcholinesterase at the peripheral anionic site: Structure-activity relationships for inhibitions by aryl carbamates
-
Lin G, Lai CY Liao WC (1999) Molecular recognition by acetylcholinesterase at the peripheral anionic site: structure-activity relationships for inhibitions by aryl carbamates. Bioorg Med Chem 7, 2683 2689.
-
(1999)
Bioorg Med Chem
, vol.7
, pp. 2683-2689
-
-
Lin, G.1
Lai, C.Y.2
Liao, W.C.3
-
54
-
-
47749102491
-
Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase
-
Darvesh S, Darvesh KV, McDonald RS, Mataija D, Walsh R, Mothana S, Lockridge O Martin E (2008) Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. J Med Chem 51, 4200 4212.
-
(2008)
J Med Chem
, vol.51
, pp. 4200-4212
-
-
Darvesh, S.1
Darvesh, K.V.2
McDonald, R.S.3
Mataija, D.4
Walsh, R.5
Mothana, S.6
Lockridge, O.7
Martin, E.8
-
55
-
-
33947480699
-
Molecular mechanisms for hydrolytic enzyme action. I. Apparent non-competitive inhibition, with special reference to acetylcholinesterase
-
Krupka RM Laidler KJ (1961) Molecular mechanisms for hydrolytic enzyme action. I. Apparent non-competitive inhibition, with special reference to acetylcholinesterase. J Am Chem Soc 83, 1445 1447.
-
(1961)
J Am Chem Soc
, vol.83
, pp. 1445-1447
-
-
Krupka, R.M.1
Laidler, K.J.2
-
56
-
-
0014959666
-
Hydrolysis of electronically and sterically defined substrates of acetylcholinesterase
-
Hillman GR Mautner HG (1970) Hydrolysis of electronically and sterically defined substrates of acetylcholinesterase. Biochemistry 9, 2633 2638.
-
(1970)
Biochemistry
, vol.9
, pp. 2633-2638
-
-
Hillman, G.R.1
Mautner, H.G.2
-
57
-
-
0344229111
-
Acetylcholinesterase: Reversible inhibitors, substrate inhibition
-
Wilson IB Alexander J (1962) Acetylcholinesterase: reversible inhibitors, substrate inhibition. J Biol Chem 237, 1323 1326.
-
(1962)
J Biol Chem
, vol.237
, pp. 1323-1326
-
-
Wilson, I.B.1
Alexander, J.2
-
58
-
-
0021126688
-
Direct determination of acetyl-enzyme intermediate in the acetylcholinesterase-catalyzed hydrolysis of acetylcholine and acetylthiocholine
-
Froede HC Wilson IB (1984) Direct determination of acetyl-enzyme intermediate in the acetylcholinesterase-catalyzed hydrolysis of acetylcholine and acetylthiocholine. J Biol Chem 259, 11010 11013.
-
(1984)
J Biol Chem
, vol.259
, pp. 11010-11013
-
-
Froede, H.C.1
Wilson, I.B.2
-
59
-
-
0029092671
-
Fasciculin 2 binds to the peripheral site on acetylcholinesterase and inhibits substrate hydrolysis by slowing a step involving proton transfer during enzyme acylation
-
Eastman J, Wilson EJ, Cerveñansky C Rosenberry TL (1995) Fasciculin 2 binds to the peripheral site on acetylcholinesterase and inhibits substrate hydrolysis by slowing a step involving proton transfer during enzyme acylation. J Biol Chem 270, 19694 19701.
-
(1995)
J Biol Chem
, vol.270
, pp. 19694-19701
-
-
Eastman, J.1
Wilson, E.J.2
Cerveñansky, C.3
Rosenberry, T.L.4
-
60
-
-
0016941453
-
The analysis of kinetic data in biochemistry. A critical evaluation of methods
-
Markus M, Hess B, Ottaway JH Cornish-Bowden A (1976) The analysis of kinetic data in biochemistry. A critical evaluation of methods. FEBS Lett 63, 225 230.
-
(1976)
FEBS Lett
, vol.63
, pp. 225-230
-
-
Markus, M.1
Hess, B.2
Ottaway, J.H.3
Cornish-Bowden, A.4
-
61
-
-
0019617042
-
The specific velocity plot. A graphical method for determining inhibition parameters for both linear and hyperbolic enzyme inhibitors
-
Baici A (1981) The specific velocity plot. A graphical method for determining inhibition parameters for both linear and hyperbolic enzyme inhibitors. Eur J Biochem 119, 9 14.
-
(1981)
Eur J Biochem
, vol.119
, pp. 9-14
-
-
Baici, A.1
-
62
-
-
0024115889
-
Pseudomonas aeruginosa acid phosphatase contains an anionic site with a trimethyl subsite. Kinetic evidences obtained with alkylammonium ions
-
Garrido MN, Lisa TA Domenech CE (1988) Pseudomonas aeruginosa acid phosphatase contains an anionic site with a trimethyl subsite. Kinetic evidences obtained with alkylammonium ions. Mol Cell Biochem 84, 41 49.
-
(1988)
Mol Cell Biochem
, vol.84
, pp. 41-49
-
-
Garrido, M.N.1
Lisa, T.A.2
Domenech, C.E.3
-
63
-
-
0019321020
-
Hydrolysis by acetylcholinesterase. Apparent molal volumes and trimethyl and methyl subsites
-
Hasan FB, Cohen SG Cohen JB (1980) Hydrolysis by acetylcholinesterase. Apparent molal volumes and trimethyl and methyl subsites. J Biol Chem 255, 3898 3904.
-
(1980)
J Biol Chem
, vol.255
, pp. 3898-3904
-
-
Hasan, F.B.1
Cohen, S.G.2
Cohen, J.B.3
-
64
-
-
0001428371
-
Molecular mechanisms for hydrolytic enzyme action. II. Inhibition of acetylcholinesterase by excess substrate
-
Krupka RM Laidler KJ (1961) Molecular mechanisms for hydrolytic enzyme action. II. Inhibition of acetylcholinesterase by excess substrate. J Am Chem Soc 83, 1448 1454.
-
(1961)
J Am Chem Soc
, vol.83
, pp. 1448-1454
-
-
Krupka, R.M.1
Laidler, K.J.2
-
65
-
-
0001169176
-
Acetylcholinesterase: Trimethylammonium-ion inhibition of deacetylation
-
Krupka RM (1964) Acetylcholinesterase: trimethylammonium-ion inhibition of deacetylation. Biochemistry 3, 1749 1754.
-
(1964)
Biochemistry
, vol.3
, pp. 1749-1754
-
-
Krupka, R.M.1
-
66
-
-
0344680000
-
Acetylcholinesterase: Structural requirements for blocking deacetylation
-
Krupka RM (1965) Acetylcholinesterase: structural requirements for blocking deacetylation. Biochemistry 4, 429 435.
-
(1965)
Biochemistry
, vol.4
, pp. 429-435
-
-
Krupka, R.M.1
-
67
-
-
54849432574
-
Inhibition of acetylcholinesterase by coumarins: The case of coumarin 106
-
Fallarero A, Oinonen P, Gupta S, Blom P, Galkin A, Mohan CG Vuorela PM (2008) Inhibition of acetylcholinesterase by coumarins: the case of coumarin 106. Pharmacol Res 58, 215 221.
-
(2008)
Pharmacol Res
, vol.58
, pp. 215-221
-
-
Fallarero, A.1
Oinonen, P.2
Gupta, S.3
Blom, P.4
Galkin, A.5
Mohan, C.G.6
Vuorela, P.M.7
-
68
-
-
0026031111
-
Role of the peripheral anionic site on acetylcholinesterase: Inhibition by substrates and coumarin derivatives
-
Radić Z, Reiner E Taylor P (1991) Role of the peripheral anionic site on acetylcholinesterase: inhibition by substrates and coumarin derivatives. Mol Pharmacol 39, 98 104.
-
(1991)
Mol Pharmacol
, vol.39
, pp. 98-104
-
-
Radić, Z.1
Reiner, E.2
Taylor, P.3
-
69
-
-
0031439890
-
Cloning and expression of acetylcholinesterase from Electrophorus. Splicing pattern of the 3′ exons in vivo and in transfected mammalian cells
-
Simon S Massoulié J (1997) Cloning and expression of acetylcholinesterase from Electrophorus. Splicing pattern of the 3′ exons in vivo and in transfected mammalian cells. J Biol Chem 272, 33045 33055.
-
(1997)
J Biol Chem
, vol.272
, pp. 33045-33055
-
-
Simon, S.1
Massoulié, J.2
-
70
-
-
0141866710
-
Inhibitors tethered near the acetylcholinesterase active site serve as molecular rulers of the peripheral and acylation sites
-
Johnson JL, Cusack B, Hughes TF, McCullough EH, Fauq A, Romanovskis P, Spatola AF Rosenberry TL (2003) Inhibitors tethered near the acetylcholinesterase active site serve as molecular rulers of the peripheral and acylation sites. J Biol Chem 278, 38948 38955.
-
(2003)
J Biol Chem
, vol.278
, pp. 38948-38955
-
-
Johnson, J.L.1
Cusack, B.2
Hughes, T.F.3
McCullough, E.H.4
Fauq, A.5
Romanovskis, P.6
Spatola, A.F.7
Rosenberry, T.L.8
-
71
-
-
0038219567
-
Unmasking tandem site interaction in human acetylcholinesterase. Substrate activation with a cationic acetanilide substrate
-
Johnson JL, Cusack B, Davies MP, Fauq A Rosenberry TL (2003) Unmasking tandem site interaction in human acetylcholinesterase. Substrate activation with a cationic acetanilide substrate. Biochemistry 42, 5438 5452.
-
(2003)
Biochemistry
, vol.42
, pp. 5438-5452
-
-
Johnson, J.L.1
Cusack, B.2
Davies, M.P.3
Fauq, A.4
Rosenberry, T.L.5
-
72
-
-
0029127347
-
Kinetic study on the inhibition of acetylcholinesterase by 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride (E2020)
-
Nochi S, Asakawa N Sato T (1995) Kinetic study on the inhibition of acetylcholinesterase by 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl] methylpiperidine hydrochloride (E2020). Biol Pharm Bull 18, 1145 1147.
-
(1995)
Biol Pharm Bull
, vol.18
, pp. 1145-1147
-
-
Nochi, S.1
Asakawa, N.2
Sato, T.3
-
73
-
-
0022448707
-
Acetylcholinesterase: Theory of noncompetitive inhibition
-
Froede HC, Wilson IB Kaufman H (1986) Acetylcholinesterase: theory of noncompetitive inhibition. Arch Biochem Biophys 247, 420 423.
-
(1986)
Arch Biochem Biophys
, vol.247
, pp. 420-423
-
-
Froede, H.C.1
Wilson, I.B.2
Kaufman, H.3
-
74
-
-
0016152998
-
Ligand binding properties of acetylcholinesterase determined with fluorescent probes
-
Mooser G Sigman DS (1974) Ligand binding properties of acetylcholinesterase determined with fluorescent probes. Biochemistry 13, 2299 2307.
-
(1974)
Biochemistry
, vol.13
, pp. 2299-2307
-
-
Mooser, G.1
Sigman, D.S.2
-
75
-
-
0027246052
-
Effet de solvents sur l'acetylcholinesterase
-
Ronzani N (1993) Effet de solvents sur l'acetylcholinesterase. Tetrahedron Lett 34, 3867 3870.
-
(1993)
Tetrahedron Lett
, vol.34
, pp. 3867-3870
-
-
Ronzani, N.1
-
76
-
-
0008750866
-
Effet de solvents sur l'acetylcholinesterase. I. Mesure de l'activité anticholinestérasique de composes hydrophobes
-
Ronzani N (1994) Effet de solvents sur l'acetylcholinesterase. I. Mesure de l'activité anticholinestérasique de composes hydrophobes. Analusis 22, 249 256.
-
(1994)
Analusis
, vol.22
, pp. 249-256
-
-
Ronzani, N.1
-
77
-
-
0034003826
-
High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural products
-
Ingkaninan K, de Best CM, van der Heijden R, Hofte AJP, Karabatak B, Irth H, Tjaden UR, van der Greef J Verpoorte R (2000) High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural products. J Chromatogr A 872, 61 73.
-
(2000)
J Chromatogr A
, vol.872
, pp. 61-73
-
-
Ingkaninan, K.1
De Best, C.M.2
Van Der Heijden, R.3
Hofte, A.J.P.4
Karabatak, B.5
Irth, H.6
Tjaden, U.R.7
Van Der Greef, J.8
Verpoorte, R.9
-
78
-
-
0037958578
-
Determining acetylcholinesterase inhibitory activity in plant extracts using a fluorimetric flow assay
-
Rhee IK, Appels N, Luijendijk H, Irth H Verpoorte R (2003) Determining acetylcholinesterase inhibitory activity in plant extracts using a fluorimetric flow assay. Phytochem Anal 14, 145 149.
-
(2003)
Phytochem Anal
, vol.14
, pp. 145-149
-
-
Rhee, I.K.1
Appels, N.2
Luijendijk, H.3
Irth, H.4
Verpoorte, R.5
-
79
-
-
33748874116
-
Organophosphorus insecticides extraction and heterogeneous oxidation on column for analysis with an acetylcholinesterase (AChE) biosensor
-
Dondoi MP, Bucur B, Danet AF, Toader CN, Barthelmebs L Marty JL (2006) Organophosphorus insecticides extraction and heterogeneous oxidation on column for analysis with an acetylcholinesterase (AChE) biosensor. Anal Chim Acta 578, 162 169.
-
(2006)
Anal Chim Acta
, vol.578
, pp. 162-169
-
-
Dondoi, M.P.1
Bucur, B.2
Danet, A.F.3
Toader, C.N.4
Barthelmebs, L.5
Marty, J.L.6
-
80
-
-
38149107667
-
Synergetic effect of organic solvents and paraoxon on the immobilized acetylcholinesterase
-
Turdean GL Turdean MS (2008) Synergetic effect of organic solvents and paraoxon on the immobilized acetylcholinesterase. Pestic Biochem Physiol 90, 73 81.
-
(2008)
Pestic Biochem Physiol
, vol.90
, pp. 73-81
-
-
Turdean, G.L.1
Turdean, M.S.2
-
81
-
-
3342993232
-
Improvement of Drosophila acetylcholinesterase stability by elimination of a free cysteine
-
Fremaux I, Mazères S, Brisson-Lougarre A, Arnaud M, Ladurantie C Fournier D (2002) Improvement of Drosophila acetylcholinesterase stability by elimination of a free cysteine. BMC Biochem 3, 21.
-
(2002)
BMC Biochem
, vol.3
, pp. 21
-
-
Fremaux, I.1
Mazères, S.2
Brisson-Lougarre, A.3
Arnaud, M.4
Ladurantie, C.5
Fournier, D.6
-
82
-
-
0028136099
-
Acetylcholinesterase in organic solvents for the detection of pesticides: Biosensor application
-
Mionetto N, Marty JL Karube I (1994) Acetylcholinesterase in organic solvents for the detection of pesticides: biosensor application. Biosens Bioelectron 9, 463 470.
-
(1994)
Biosens Bioelectron
, vol.9
, pp. 463-470
-
-
Mionetto, N.1
Marty, J.L.2
Karube, I.3
-
83
-
-
0033522370
-
'Back door' opening implied by the crystal structure of a carbamoylated acetylcholinesterase
-
Bartolucci C, Perola E, Cellai L, Brufani M Lamba D (1999) 'Back door' opening implied by the crystal structure of a carbamoylated acetylcholinesterase. Biochemistry 38, 5714 5719.
-
(1999)
Biochemistry
, vol.38
, pp. 5714-5719
-
-
Bartolucci, C.1
Perola, E.2
Cellai, L.3
Brufani, M.4
Lamba, D.5
-
84
-
-
36248987741
-
Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography
-
Colletier JP, Royant A, Specht A, Sanson B, Nachon F, Masson P, Zaccai G, Sussman JL, Goeldner M, Silman I et al. (2007) Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography. Acta Crystallogr D Biol Crystallogr 63, 1115 1128.
-
(2007)
Acta Crystallogr D Biol Crystallogr
, vol.63
, pp. 1115-1128
-
-
Colletier, J.P.1
Royant, A.2
Specht, A.3
Sanson, B.4
Nachon, F.5
Masson, P.6
Zaccai, G.7
Sussman, J.L.8
Goeldner, M.9
Silman, I.10
-
85
-
-
42649083300
-
Insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel
-
Nachon F, Stojan J Fournier D (2008) Insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel. FEBS J 275, 2659 2664.
-
(2008)
FEBS J
, vol.275
, pp. 2659-2664
-
-
Nachon, F.1
Stojan, J.2
Fournier, D.3
-
86
-
-
0028179616
-
Open 'back door' in a molecular dynamics simulation of acetylcholinesterase
-
Gilson MK, Straatsma TP, McCammon JA, Ripoll DR, Faerman CH, Axelsen PH, Silman I Sussman JL (1994) Open 'back door' in a molecular dynamics simulation of acetylcholinesterase. Science 263, 1276 1278.
-
(1994)
Science
, vol.263
, pp. 1276-1278
-
-
Gilson, M.K.1
Straatsma, T.P.2
McCammon, J.A.3
Ripoll, D.R.4
Faerman, C.H.5
Axelsen, P.H.6
Silman, I.7
Sussman, J.L.8
-
87
-
-
33747456049
-
Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-Alzheimer drug ganstigmine (CHF-2819)
-
Bartolucci C, Siotto M, Ghidini E, Amari G, Bolzoni PT, Racchi M, Viletti G, Delcanale M Lamba D (2006) Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-Alzheimer drug ganstigmine (CHF-2819). J Med Chem 49, 5051 5058.
-
(2006)
J Med Chem
, vol.49
, pp. 5051-5058
-
-
Bartolucci, C.1
Siotto, M.2
Ghidini, E.3
Amari, G.4
Bolzoni, P.T.5
Racchi, M.6
Viletti, G.7
Delcanale, M.8
Lamba, D.9
|