HPV, KRAS mutations, alcohol consumption and tobacco smoking effects on Sophageal squamous-cell carcinoma carcinogenesis

International Journal of Biological Markers

Volumn 27, Issue 1, 2012, Pages 1-2

  Radojicic, Jelena ^a   Zaravinos, Apostolos ^a   Spandidos, Demetrios A ^a  

^a UNIVERSITY OF CRETE   (Greece)

Author keywords

Alcohol consumption; Esophageal squamous cell carcinoma; Human papilloma virus; KRAS mutations; Tobacco use

Indexed keywords

ALCOHOL; DNA; K RAS PROTEIN; RAS PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ALCOHOL CONSUMPTION; APOPTOSIS; CANCER CELL; CANCER INCIDENCE; CANCER PATIENT; CANCER RESEARCH; CARCINOGENESIS; CELL CYCLE REGULATION; CELL PROLIFERATION; CIGARETTE SMOKING; CLINICAL ASSESSMENT; DIET; DNA DAMAGE; DRINKING BEHAVIOR; ENVIRONMENTAL FACTOR; EPIDEMIOLOGICAL DATA; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; ESOPHAGUS MUCOSA; FOOD PRESERVATION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC VARIABILITY; GROWTH INHIBITION; HEALTH HAZARD; MUTAGENIC ACTIVITY; NORTH AMERICA; NUTRITIONAL DEFICIENCY; ONCOGENE; PAPILLOMAVIRUS INFECTION; REVIEW; RISK FACTOR; SOCIAL STATUS; SURVIVAL RATE; TOBACCO; TUMOR SUPPRESSOR GENE; UTERINE CERVIX CARCINOMA; VIRUS INFECTION; VIRUS LOAD; WART VIRUS; WESTERN EUROPE;

ALCOHOL DRINKING; ALPHAPAPILLOMAVIRUS; CARCINOMA, SQUAMOUS CELL; CELL TRANSFORMATION, NEOPLASTIC; ESOPHAGEAL NEOPLASMS; HUMANS; PAPILLOMAVIRUS INFECTIONS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTO-ONCOGENE PROTEINS; RAS PROTEINS; RISK FACTORS; SMOKING;

HUMAN PAPILLOMAVIRUS; NICOTIANA TABACUM;

EID: 84863910369     PISSN: 03936155     EISSN: None     Source Type: Journal    
DOI: 10.5301/JBM.2011.8737     Document Type: Review

References (196)

1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127: 2893-17.
2. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74-108.
3. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90.
4. Collard JM, Otte JB, Fiasse R, et al. Skeletonizing en bloc esophagectomy for cancer. Ann Surg 2001; 234: 25-32.
5. Siewert JR, Stein HJ, Feith M, Bruecher BL, Bartels H, Fink U. Histologic tumor type is an independent prognostic parameter in esophageal cancer: lessons from more than 1,000 consecutive resections at a single center in the Western world. Ann Surg 2001; 234: 360-9.
6. Risk JM, Mills HS, Garde J, et al. The tylosis esophageal cancer (TOC) locus: more than just a familial cancer gene. Dis Esophagus 1999; 12: 173-6.
7. Engeland A, Haldorsen T, Tretli S, et al. Prediction of cancer incidence in the Nordic countries up to the years 2000 and 2010. A collaborative study of the five Nordic Cancer Registries. APMIS Suppl 1993; 38: 1-124.
8. Daly JM, Fry WA, Little AG, et al. Esophageal cancer: results of an American College of Surgeons Patient Care Evaluation Study. J Am Coll Surg 2000; 190: 562-73.
9. Wang GQ, Abnet CC, Shen Q, et al. Histological precursors of oesophageal squamous cell carcinoma: results from a 13 year prospective follow up study in a high risk population. Gut 2005; 54: 187-92.
10. Kaneko K, Murakami Y, Katagiri A, et al. Does daily alcohol and/or cigarette consumption cause low-grade dysplasia, a precursor of esophageal squamous cell carcinoma? J Clin Gastroenterol; 44: 173-9.
11. Juhasz A, Mittal SK, Lee TH, Deng C, Chak A, Lynch HT. Prevalence of Barrett esophagus in first-degree relatives of patients with esophageal adenocarcinoma. J Clin Gastroenterol 2011; May 25 [Epub ahead of print].
12. Toh Y, Oki E, Ohgaki K, et al. Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: molecular mechanisms of carcinogenesis. Int J Clin Oncol 2010; 15: 135-44.
13. Lam AK. Molecular biology of esophageal squamous cell carcinoma. Crit Rev Oncol Hematol 2000; 33: 71-90.
14. Syrjanen KJ. HPV infections and oesophageal cancer. J Clin Pathol 2002; 55: 721-8.
15. Parkin PC, Taylor CY, Petric M, Schuh S, Goldbach M, Ipp M. Controlled study of respiratory viruses and wheezing. Arch Dis Child 2002; 87: 221-2.
16. Dawsey SP, Tonui S, Parker RK, et al. Esophageal cancer in young people: a case series of 109 cases and review of the literature. PLoS One 2010; 5: e14080.
17. Li T, Lu ZM, Chen KN, et al. Human papillomavirus type 16 is an important infectious factor in the high incidence of esophageal cancer in Anyang area of China. Carcinogenesis 2001; 22: 929-34.
18. Farhadi M, Tahmasebi Z, Merat S, Kamangar F, Nasrollahzadeh D, Malekzadeh R. Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population. World J Gastroenterol 2005; 11: 1200-3.
19. Chang F, Syrjanen S, Wang L, Syrjanen K. Infectious agents in the etiology of esophageal cancer. Gastroenterology 1992; 103: 1336-48.
20. Stemmermann G, Heffelfinger SC, Noffsinger A, Hui YZ, Miller MA, Fenoglio-Preiser CM. The molecular biology of esophageal and gastric cancer and their precursors: oncogenes, tumor suppressor genes, and growth factors. Hum Pathol 1994; 25: 968-81.
21. Brown LM, Hoover R, Silverman D, et al. Excess incidence of squamous cell esophageal cancer among US Black men: role of social class and other risk factors. Am J Epidemiol 2001; 153: 114-22.
22. Wu AH, Wan P, Bernstein L. A multiethnic population-based study of smoking, alcohol and body size and risk of adenocarcinomas of the stomach and esophagus (United States). Cancer Causes Control 2001; 12: 721-32.
23. Erkal HS, Mendenhall WM, Amdur RJ, Villaret DB, Stringer SP. Synchronous and metachronous squamous cell carcinomas of the head and neck mucosal sites. J Clin Oncol 2001; 19: 1358-62.
24. Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of eighteen major cancers in 1985. Int J Cancer 1993; 54: 594-606.
25. Smits HL, Tjong AHSP, ter Schegget J, Nooter K, Kok T. Absence of human papillomavirus DNA from esophageal carcinoma as determined by multiple broad spectrum polymerase chain reactions. J Med Virol 1995; 46: 213-5.
26. Lavergne D, de Villiers EM. Papillomavirus in esophageal papillomas and carcinomas. Int J Cancer 1999; 80: 681-4.
27. Matsha T, Erasmus R, Kafuko AB, Mugwanya D, Stepien A, Parker MI. Human papillomavirus associated with oesophageal cancer. J Clin Pathol 2002; 55: 587-90.
28. Lyronis ID, Baritaki S, Bizakis I, Krambovitis E, Spandidos DA. K-ras mutation, HPV infection and smoking or alcohol abuse positively correlate with esophageal squamous carcinoma. Pathol Oncol Res 2008; 14: 267-73.
29. Wang X, Tian X, Liu F, et al. Detection of HPV DNA in esophageal cancer specimens from different regions and ethnic groups: a descriptive study. BMC Cancer 2010; 10: 19.
30. Kim SH, Lee KS, Shim YM, Kim K, Yang PS, Kim TS. Esophageal resection: indications, techniques, and radiologic assessment. Radiographics 2001; 21: 1119-40.
31. Yoshizawa T, Yamashita A, Luo Y. Fumonisin occurrence in corn from high- and low-risk areas for human esophageal cancer in China. Appl Environ Microbiol 1994; 60: 1626-9.
32. Talamini G, Capelli P, Zamboni G, et al. Alcohol, smoking and papillomavirus infection as risk factors for esophageal squamous-cell papilloma and esophageal squamous-cell carcinoma in Italy. Int J Cancer 2000; 86: 874-8.
33. Marasas WF. Discovery and occurrence of the fumonisins: a historical perspective. Environ Health Perspect 2001; 109 (Suppl 2): 239-43.
34. Tavani A, Bertuzzi M, Talamini R, et al. Coffee and tea intake and risk of oral, pharyngeal and esophageal cancer. Oral Oncol 2003; 39: 695-700.
35. Zheng S, Vuitton L, Sheyhidin I, Vuitton DA, Zhang Y, Lu X. Northwestern China: a place to learn more on oesophageal cancer. Part one: behavioural and environmental risk factors. Eur J Gastroenterol Hepatol 2010; 22: 917-25.
36. Zendehdel K, Nyren O, Edberg A, Ye W. Risk of esophageal adenocarcinoma in achalasia patients, a retrospective cohort study in Sweden. Am J Gastroenterol 2011; 106: 57-61.
37. Sandler RS, Nyren O, Ekbom A, Eisen GM, Yuen J, Josefsson S. The risk of esophageal cancer in patients with achalasia. A population-based study. JAMA 1995; 274: 1359-62.
38. Avisar E, Luketich JD. Adenocarcinoma in a mid-esophageal diverticulum. Ann Thorac Surg 2000; 69: 288-9.
39. Leeuwenburgh I, Scholten P, Alderliesten J, et al. Long-term esophageal cancer risk in patients with primary achalasia: a prospective study. Am J Gastroenterol 2010; 105: 2144-9.
40. Spandidos DA. Oncogenes and tumor suppressor genes as paradigms in oncogenesis. J BUON 2007; 12 (Suppl 1): S9-12.
41. Ohashi S, Natsuizaka M, Wong GS, et al. Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors. Cancer Res 2010; 70: 4174-84.
42. Ellis A, Field JK, Field EA, et al. Tylosis associated with carcinoma of the oesophagus and oral leukoplakia in a large Liverpool family--a review of six generations. Eur J Cancer B Oral Oncol 1994; 30B: 102-12.
43. zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2002; 2: 342-50.
44. Bosch FX, Manos MM, Munoz N, et al. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International Biological Study on Cervical Cancer (IBSCC) Study Group. J Natl Cancer Inst 1995; 87: 796-802.
45. Walboomers JM, Jacobs MV, Manos MM, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999; 189: 12-9.
46. Woodman CB, Collins SI, Young LS. The natural history of cervical HPV infection: unresolved issues. Nat Rev Cancer 2007; 7: 11-22.
47. Kiviat NB. Papillomaviruses in non-melanoma skin cancer: epidemiological aspects. Semin Cancer Biol 1999; 9: 397-403.
48. Accardi R, Dong W, Smet A, et al. Skin human papillomavirus type 38 alters p53 functions by accumulation of deltaNp73. EMBO Rep 2006; 7: 334-40.
49. Zaravinos A, Kanellou P, Spandidos DA. Viral DNA detection and RAS mutations in actinic keratosis and nonmelanoma skin cancers. Br J Dermatol 2010; 162: 325-31.
50. Mammas IN, Sourvinos G, Zaravinos A, Spandidos DA. Vaccination against human papilloma virus (HPV): epidemiological evidence of HPV in non-genital cancers. Pathol Oncol Res 2011; 17: 103-19.
51. Gillison ML, Koch WM, Capone RB, et al. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 2000; 92: 709-20.
52. Strome SE, Savva A, Brissett AE, et al. Squamous cell carcinoma of the tonsils: a molecular analysis of HPV associations. Clin Cancer Res 2002; 8: 1093-100.
53. Fakhry C, Gillison ML. Clinical implications of human papillomavirus in head and neck cancers. J Clin Oncol 2006; 24: 2606-11.
54. Zaravinos A, Bizakis J, Spandidos DA. Prevalence of human papilloma virus and human herpes virus types 1-7 in human nasal polyposis. J Med Virol 2009; 81: 1613-9.
55. Syrjanen KJ. Histological changes identical to those of condylomatous lesions found in esophageal squamous cell carcinomas. Arch Geschwulstforsch 1982; 52: 283-92.
56. Dillner J, Knekt P, Schiller JT, Hakulinen T. Prospective seroepidemiological evidence that human papillomavirus type 16 infection is a risk factor for oesophageal squamous cell carcinoma. BMJ 1995; 311: 1346.
57. Zaravinos A, Mammas IN, Sourvinos G, Spandidos DA. Molecular detection methods of human papillomavirus (HPV). Int J Biol Markers 2009; 24: 215-22.
58. de Villiers EM, Gunst K, Stein H, Scherubl H. Esophageal squamous cell cancer in patients with head and neck cancer: prevalence of human papillomavirus DNA sequences. Int J Cancer 2004; 109: 253-8.
59. Hille JJ, Margolius KA, Markowitz S, Isaacson C. Human papillomavirus infection related to oesophageal carcinoma in black South Africans. A preliminary study. S Afr Med J 1986; 69: 417-20.
60. Chang F, Syrjanen S, Shen Q, et al. Evaluation of HPV, CMV, HSV and EBV in esophageal squamous cell carcinomas from a high-incidence area of China. Anticancer Res 2000; 20: 3935-40.
61. Chang F, Syrjanen S, Shen Q, et al. Human papillomavirus involvement in esophageal carcinogenesis in the high-incidence area of China. A study of 700 cases by screening and type-specific in situ hybridization. Scand J Gastroenterol 2000; 35: 123-30.
62. Kamath AM, Wu TT, Heitmiller R, Daniel R, Shah KV. Investigation of the association of esophageal carcinoma with human papillomaviruses. Dis Esophagus 2000; 13: 122-4.
63. Astori G, Merluzzi S, Arzese A, et al. Detection of human papillomavirus DNA and p53 gene mutations in esophageal cancer samples and adjacent normal mucosa. Digestion 2001; 64: 9-14.
64. Souto Damin AP, Guedes Frazzon AP, de Carvalho Damin D, et al. Detection of human papillomavirus DNA in squamous cell carcinoma of the esophagus by auto-nested PCR. Dis Esophagus 2006; 19: 64-8.
65. Li TT, Zhao LN, Liu ZG, Han Y, Fan DM. Regulation of apoptosis by the papillomavirus E6 oncogene. World J Gastroenterol 2005; 11: 931-7.
66. Poljak M, Cerar A, Seme K. Human papillomavirus infection in esophageal carcinomas: a study of 121 lesions using multiple broad-spectrum polymerase chain reactions and literature review. Hum Pathol 1998; 29: 266-71.
67. Fidalgo PO, Cravo ML, Chaves PP, Leitao CN, Mira FC. High prevalence of human papillomavirus in squamous cell carcinoma and matched normal esophageal mucosa: assessment by polymerase chain reaction. Cancer 1995; 76: 1522-8.
68. Lyronis ID, Baritaki S, Bizakis I, Tsardi M, Spandidos DA. Evaluation of the prevalence of human papillomavirus and Epstein-Barr virus in esophageal squamous cell carcinomas. Int J Biol Markers 2005; 20: 5-10.
69. Zhang D, Zhang Q, Zhou L, et al. Comparison of prevalence, viral load, physical status and expression of human papillomavirus-16, -18 and -58 in esophageal and cervical cancer: a case-control study. BMC Cancer 2010; 10: 650.
70. Yang G, Zhang Z, Liao J, et al. Immunohistochemical studies on Waf1p21, p16, pRb and p53 in human esophageal carcinomas and neighboring epithelia from a high-risk area in northern China. Int J Cancer 1997; 72: 746-51.
71. Zhang QY, Zhang DH, Shen ZY, Xu LY, Li EM, Au WW. Infection and integration of human papillomavirus in esophageal carcinoma. Int J Hyg Environ Health 2011; 214: 156-61.
72. Suzuk L, Noffsinger AE, Hui YZ, Fenoglio-Preiser CM. Detection of human papillomavirus in esophageal squamous cell carcinoma. Cancer 1996; 78: 704-10.
73. Turner JR, Shen LH, Crum CP, Dean PJ, Odze RD. Low prevalence of human papillomavirus infection in esophageal squamous cell carcinomas from North America: analysis by a highly sensitive and specific polymerase chain reaction-based approach. Hum Pathol 1997; 28: 174-8.
74. Awerkiew S, Bollschweiler E, Metzger R, Schneider PM, Holscher AH, Pfister H. Esophageal cancer in Germany is associated with Epstein-Barr-virus but not with papillomaviruses. Med Microbiol Immunol 2003; 192: 137-40.
75. Shen Z Y, Xu LY, Li EM, et al. The multistage process of carcinogenesis in human esophageal epithelial cells induced by human papillomavirus. Oncol Rep 2004; 11: 647-54.
76. Hunter KD, Parkinson EK, Harrison PR. Profiling early head and neck cancer. Nat Rev Cancer 2005; 5: 127-35.
77. Pillai MR, Nair MK. Development of a condemned mucosa syndrome and pathogenesis of human papillomavirus-associated upper aerodigestive tract and uterine cervical tumors. Exp Mol Pathol 2000; 69: 233-41.
78. Si HX, Tsao SW, Poon CS, Wong YC, Cheung AL. Physical status of HPV-16 in esophageal squamous cell carcinoma. J Clin Virol 2005; 32: 19-23.
79. Shen Z, Cen S, Shen J, et al. Study of immortalization and malignant transformation of human embryonic esophageal epithelial cells induced by HPV18 E6E7. J Cancer Res Clin Oncol 2000; 126: 589-94.
80. Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 1990; 63: 1129-36.
81. Liu Y, Chen JJ, Gao Q, et al. Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells. J Virol 1999; 73: 7297-307.
82. Hengstermann A, Linares LK, Ciechanover A, Whitaker NJ, Scheffner M. Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells. Proc Natl Acad Sci U S A 2001; 98: 1218-23.
83. Qi ZL, Huo X, Xu XJ, et al. Relationship between HPV16/18 E6 and 53, 21WAF1, MDM2, Ki67 and cyclin D1 expression in esophageal squamous cell carcinoma: comparative study by using tissue microarray technology. Exp Oncol 2006; 28: 235-40.
84. Xu AG, Li SG, Liu JH, Gan AH. Function of apoptosis and expression of the proteins Bcl-2, p53 and C-myc in the development of gastric cancer. World J Gastroenterol 2001; 7: 403-406.
85. Wang XJ, Yuan SL, Li CP, et al. Infrequent p53 gene mutation and expression of the cardia adenocarcinomas from a high-incidence area of Southwest China. World J Gastroenterol 2000; 6: 750-3.
86. Lin GY, Chen ZL, Lu CM, Li Y, Ping XJ, Huang R. Immunohistochemical study on p53, H-rasp21, c-erbB-2 protein and PCNA expression in HCC tissues of Han and minority ethnic patients. World J Gastroenterol 2000; 6: 234-8.
87. zur Hausen H. Papillomavirus infections--a major cause of human cancers. Biochim Biophys Acta 1996; 1288: F55-78.
88. Wazer DE, Liu XL, Chu Q, Gao Q, Band V. Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7. Proc Natl Acad Sci U S A 1995; 92: 3687-91.
89. Baines JE, McGovern RM, Persing D, Gostout BS. Consensus-degenerate hybrid oligonucleotide primers (CODEHOP) for the detection of novel papillomaviruses and their application to esophageal and tonsillar carcinomas. J Virol Methods 2005; 123: 81-7.
90. de Villiers EM, Lavergne D, Chang F, et al. An interlaboratory study to determine the presence of human papillomavirus DNA in esophageal carcinoma from China. Int J Cancer 1999; 81: 225-8.
91. Koshiol J, Wei WQ, Kreimer AR, et al. No role for human papillomavirus in esophageal squamous cell carcinoma in China. Int J Cancer 2010; 127: 93-100.
92. Lu S, Luo F, Li H. Detection of human papilloma virus in esophageal squamous cell carcinoma and adjacent tissue specimens in Linxian. Zhonghua Zhong Liu Za Zhi 1995; 17: 321-4.
93. Si HX, Tsao SW, Poon CS, Wang LD, Wong YC, Cheung AL. Viral load of HPV in esophageal squamous cell carcinoma. Int J Cancer 2003; 103: 496-500.
94. Cao B, Tian X, Li Y, Jiang P, et al. LMP7/TAP2 gene polymorphisms and HPV infection in esophageal carcinoma patients from a high incidence area in China. Carcinogenesis 2005; 26: 1280-4.
95. Li S Y, Li Y, Wang LD, et al. Detection of human papillomavirus in tissues of esophageal carcinomas by polymerase chain reaction. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2008; 22: 251-3.
96. Barbacid M. Ras genes. Annu Rev Biochem 1987; 56: 779-827.
97. Kiaris H, Spandidos D. Mutations of ras genes in human tumors (review). Int J Oncol 1995; 7: 413-21.
98. Der CJ, Krontiris TG, Cooper GM. Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses. Proc Natl Acad Sci U S A 1982; 79: 3637-40.
99. Wittinghofer A, Pai EF. The structure of Ras protein: a model for a universal molecular switch. Trends Biochem Sci 1991; 16: 382-7.
100. Khosravi-Far R, Der CJ. The Ras signal transduction pathway. Cancer Metastasis Rev 1994; 13: 67-89.
101. Kiaris H, Spandidos DA, Jones AS, Vaughan ED, Field JK. Mutations, expression and genomic instability of the H-ras proto-oncogene in squamous cell carcinomas of the head and neck. Br J Cancer 1995; 72: 123-8.
102. Spandidos DA, Wilkie NM. Malignant transformation of early passage rodent cells by a single mutated human oncogene. Nature 1984; 310: 469-75.
103. Downward J. Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 2003; 3: 11-22.
104. Bos JL, Fearon ER, Hamilton SR, et al. Prevalence of ras gene mutations in human colorectal cancers. Nature 1987; 327: 293-7.
105. Zachos G, Spandidos DA. Expression of ras proto-oncogenes: regulation and implications in the development of human tumors. Crit Rev Oncol Hematol 1997; 26: 65-75.
106. Russo A, Bazan V, Agnese V, Rodolico V, Gebbia N. Prognostic and predictive factors in colorectal cancer: Kirsten Ras in CRC (RASCAL) and TP53CRC collaborative studies. Ann Oncol 2005; 16 (Suppl 4): iv44-9.
107. Kim IJ, Park JH, Kang HC, et al. Mutational analysis of BRAF and K-ras in gastric cancers: absence of BRAF mutations in gastric cancers. Hum Genet 2003; 114: 118-20.
108. Wu CM, Tang R, Wang JY, Changchien CR, Hsieh LL. Frequency and spectrum of K-RAS codons 12 and 13 mutations in colorectal adenocarcinomas from Taiwan. Cancer Genet Cytogenet 2005; 158: 55-60.
109. Soman NR, Wogan GN. Activation of the c-Ki-ras oncogene in aflatoxin B1-induced hepatocellular carcinoma and adenoma in the rat: detection by denaturing gradient gel electrophoresis. Proc Natl Acad Sci U S A 1993; 90: 2045-9.
110. Smit VT, Boot AJ, Smits AM, Fleuren GJ, Cornelisse CJ, Bos JL. KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas. Nucleic Acids Res 1988; 16: 7773-82.
111. Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988; 319: 525-532.
112. Boughdady IS, Kinsella AR, Haboubi NY, Schofield PF. K-ras gene mutations in adenomas and carcinomas of the colon. Surg Oncol 1992; 1: 275-82.
113. Finkelstein SD, Sayegh R, Christensen S, Swalsky PA. Genotypic classification of colorectal adenocarcinoma. Biologic behavior correlates with K-ras-2 mutation type. Cancer 1993; 71: 3827-38.
114. Symvoulakis EK, Zaravinos A, Panutsopulos D, et al. Highly conserved sequence of exon 15 BRAF gene and KRAS codon 12 mutation among Greek patients with colorectal cancer. Int J Biol Markers 2007; 22: 12-8.
115. Lord RV, O'Grady R, Sheehan C, Field AF, Ward RL. K-ras codon 12 mutations in Barrett's oesophagus and adenocarcinomas of the oesophagus and oesophagogastric junction. J Gastroenterol Hepatol 2000; 15: 730-6.
116. Sommerer F, Vieth M, Markwarth A, et al. Mutations of BRAF and KRAS2 in the development of Barrett's adenocarcinoma. Oncogene 2004; 23: 554-8.
117. Lee JH, Lee SK, Yang MH, Ahmed MM, Mohiuddin M, Lee E Y. Expression and mutation of H-ras in uterine cervical cancer. Gynecol Oncol 1996; 62: 49-54.
118. Wong YF, Chung TK, Cheung TH, Lam SK, Xu YG, Chang AM. Frequent ras gene mutations in squamous cell cervical cancer. Cancer Lett 1995; 95: 29-32.
119. Grendys EC, Jr, Barnes WA, Weitzel J, Sparkowski J, Schlegel R. Identification of H, K, and N-ras point mutations in stage IB cervical carcinoma. Gynecol Oncol 1997; 65: 343-7.
120. Ahuja HG, Foti A, Bar-Eli M, Cline MJ. The pattern of mutational involvement of RAS genes in human hematologic malignancies determined by DNA amplification and direct sequencing. Blood 1990; 75: 1684-90.
121. Burchill SA, Neal DE, Lunec J. Frequency of H-ras mutations in human bladder cancer detected by direct sequencing. Br J Urol 1994; 73: 516-21.
122. Miyakis S, Sourvinos G, Spandidos DA. Differential expression and mutation of the ras family genes in human breast cancer. Biochem Biophys Res Commun 1998; 251: 609-12.
123. Spandidos DA, Kerr IB. Elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectum. Br J Cancer 1984; 49: 681-8.
124. Boulalas I, Zaravinos A, Karyotis I, Delakas D, Spandidos DA. Activation of RAS family genes in urothelial carcinoma. J Urol 2009; 181: 2312-9.
125. Mammas IN, Zafiropoulos A, Koumantakis E, Sifakis S, Spandidos DA. Transcriptional activation of H- and N-ras oncogenes in human cervical cancer. Gynecol Oncol 2004; 92: 941-8.
126. Zaravinos A, Bizakis J, Soufla G, Sourvinos G, Spandidos DA. Mutations and differential expression of the ras family genes in human nasal polyposis. Int J Oncol 2007; 31: 1051-9.
127. Spandidos DA, Sourvinos G, Tsatsanis C, Zafiropoulos A. Normal ras genes: their onco-suppressor and pro-apoptotic functions (review). Int J Oncol 2002; 21: 237-41.
128. Hamada M, Naomoto Y, Shirakawa Y, et al. p53 expression and p21 expression are mutually exclusive in esophageal squamous cell carcinoma. Oncol Rep 2004; 11: 57-63.
129. Dokianakis DN, Sourvinos G, Sakkas S, Athanasiadou E, Spandidos DA. Detection of HPV and ras gene mutations in cervical smears from female genital lesions. Oncol Rep 1998; 5: 1195-8.
130. Casson AG, Wilson SM, McCart JA, et al. Ras mutation and expression of the ras-regulated genes osteopontin and cathepsin L in human esophageal cancer. Int J Cancer 1997; 72: 739-45.
131. Mouron SA, Abba MC, Guerci A, Gomez MA, Dulout FN, Golijow CD. Association between activated K-ras and c-erbB-2 oncogenes with "high-risk" and "low-risk" human papilloma virus types in preinvasive cervical lesions. Mutat Res 2000; 469: 127-34.
132. Prokopakis P, Sourvinos G, Koumantaki Y, Koumantakis E, Spandidos DA. K-ras mutations and HPV infection in cervicitis and intraepithelial neoplasias of the cervix. Oncol Rep 2002; 9: 129-33.
133. Kornaros S, Liloglou T, Politou M, Elemenoglou I. Colorectal adenomas with a low frequency of ki-ras mutations: a sample from a population with a low mortality rate from colorectal cancer. Colorectal Dis 2005; 7: 323-6.
134. Buyru N, Budak M, Yazici H, Dalay N. p53 gene mutations are rare in human papillomavirus-associated colon cancer. Oncol Rep 2003; 10: 2089-92.
135. Bodaghi S, Yamanegi K, Xiao SY, Da Costa M, Palefsky JM, Zheng ZM. Colorectal papillomavirus infection in patients with colorectal cancer. Clin Cancer Res 2005; 11: 2862-7.
136. Perez LO, Abba MC, Laguens RM, Golijow CD. Analysis of adenocarcinoma of the colon and rectum: detection of human papillomavirus (HPV) DNA by polymerase chain reaction. Colorectal Dis 2005; 7: 492-5.
137. Perez LO, Barbisan G, Ottino A, Pianzola H, Golijow CD. Human papillomavirus DNA and oncogene alterations in colorectal tumors. Pathol Oncol Res 2010; 16: 461-8.
138. Mazurek S, Zwerschke W, Jansen-Durr P, Eigenbrodt E. Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7. Oncogene 2001; 20: 6891-8.
139. Poschl G, Stickel F, Wang XD, Seitz HK. Alcohol and cancer: genetic and nutritional aspects. Proc Nutr Soc 2004; 63: 65-71.
140. Fan Y, Yuan JM, Wang R, Gao YT, Yu MC. Alcohol, tobacco, and diet in relation to esophageal cancer: the Shanghai Cohort Study. Nutr Cancer 2008; 60: 354-63.
141. Tavani A, Negri E, Franceschi S, La Vecchia C. Risk factors for esophageal cancer in women in northern Italy. Cancer 1993; 72: 2531-6.
142. Homann N. Alcohol and upper gastrointestinal tract cancer: the role of local acetaldehyde production. Addict Biol 2001; 6: 309-23.
143. Lieber CS. Metabolism of alcohol. Clin Liver Dis 2005; 9: 1-35.
144. Lee CH, Lee JM, Wu DC, et al. Carcinogenetic impact of ADH1B and ALDH2 genes on squamous cell carcinoma risk of the esophagus with regard to the consumption of alcohol, tobacco and betel quid. Int J Cancer 2008; 122: 1347-56.
145. Seitz HK, Stickel F. Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer 2007; 7: 599-612.
146. Yin SJ, Chou FJ, Chao SF, et al. Alcohol and aldehyde dehydrogenases in human esophagus: comparison with the stomach enzyme activities. Alcohol Clin Exp Res 1993; 17: 376-81.
147. Franke A, Teyssen S, Singer M V. Alcohol-related diseases of the esophagus and stomach. Dig Dis 2005; 23: 204-13.
148. Jelski W, Zalewski B, Szmitkowski M. The activity of class I, II, III, and IV alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in liver cancer. Dig Dis Sci 2008; 53: 2550-5.
149. Parlesak A, Menzl I, Feuchter A, Bode JC, Bode C. Inhibition of retinol oxidation by ethanol in the rat liver and colon. Gut 2000; 47: 825-31.
150. Xu XC. Risk factors and gene expression in esophageal cancer. Methods Mol Biol 2009; 471: 335-60.
151. Seitz HK, Stickel F. Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress. Biol Chem 2006; 387: 349-60.
152. Baldin V, Lukas J, Marcote MJ, Pagano M, Draetta G. Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev 1993; 7: 812-21.
153. Kuwano H, Kato H, Miyazaki T, et al. Genetic alterations in esophageal cancer. Surg Today 2005; 35: 7-18.
154. Bizari L, Borim AA, Leite KR, et al. Alterations of the CCND1 and HER-2/neu (ERBB2) proteins in esophageal and gastric cancers. Cancer Genet Cytogenet 2006; 165: 41-50.
155. Baylin SB. DNA methylation and gene silencing in cancer. Nat Clin Pract Oncol 2005; 2 (Suppl 1): S4-11.
156. Yokoyama A, Muramatsu T, Omori T, et al. Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics. Carcinogenesis 2001; 22: 433-9.
157. Guo YM, Wang Q, Liu YZ, Chen HM, Qi Z, Guo QH. Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males. World J Gastroenterol 2008; 14: 1444-9.
158. Chen YJ, Chen C, Wu DC, et al. Interactive effects of lifetime alcohol consumption and alcohol and aldehyde dehydrogenase polymorphisms on esophageal cancer risks. Int J Cancer 2006; 119: 2827-31.
159. Smith M. Genetics of human alcohol and aldehyde dehydrogenases. Adv Hum Genet 1986; 15: 249-90.
160. Bosron WF, Li TK. Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism. Hepatology 1986; 6: 502-10.
161. Crabb DW, Edenberg HJ, Bosron WF, Li TK. Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. J Clin Invest 1989; 83: 314-6.
162. Borinskaya S, Kal'ina N, Marusin A, et al. Distribution of the alcohol dehydrogenase ADH1B*47His allele in Eurasia. Am J Hum Genet 2009; 84: 89-92; author reply 92-4.
163. Harada S, Agarwal DP, Goedde HW. Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese. Lancet 1981; 2: 982.
164. Eng MY, Luczak SE, Wall TL. ALDH2, ADH1B, and ADH1C genotypes in Asians: a literature review. Alcohol Res Health 2007; 30: 22-7.
165. Brooks PJ, Enoch MA, Goldman D, Li TK, Yokoyama A. The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption. PLoS Med 2009; 6: e50.
166. Chamulitrat W, Spitzer JJ. Nitric oxide and liver injury in alcohol-fed rats after lipopolysaccharide administration. Alcohol Clin Exp Res 1996; 20: 1065-70.
167. Homann N, Seitz HK, Wang XD, Yokoyama A, Singletary KW, Ishii H. Mechanisms in alcohol-associated carcinogenesis. Alcohol Clin Exp Res 2005; 29: 1317-20.
168. Hu W, Feng Z, Eveleigh J, et al. The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma. Carcinogenesis 2002; 23: 1781-9.
169. Wu D, Zhai Q, Shi X. Alcohol-induced oxidative stress and cell responses. J Gastroenterol Hepatol 2006; 21 (Suppl 3): S26-9.
170. Mena S, Ortega A, Estrela JM. Oxidative stress in environmental-induced carcinogenesis. Mutat Res 2009; 674: 36-44.
171. Hecht SS. Tobacco carcinogens, their biomarkers and tobacco-induced cancer. Nat Rev Cancer 2003; 3: 733-44.
172. Sakata K, Hoshiyama Y, Morioka S, Hashimoto T, Takeshita T, Tamakoshi A. Smoking, alcohol drinking and esophageal cancer: findings from the JACC Study. J Epidemiol 2005; 15 (Suppl 2): S212-9.
173. Castellsague X, Munoz N, De Stefani E, et al. Independent and joint effects of tobacco smoking and alcohol drinking on the risk of esophageal cancer in men and women. Int J Cancer 1999; 82: 657-64.
174. Launoy G, Milan CH, Faivre J, Pienkowski P, Milan CI, Gignoux M. Alcohol, tobacco and oesophageal cancer: effects of the duration of consumption, mean intake and current and former consumption. Br J Cancer 1997; 75: 1389-96.
175. Lee CH, Wu DC, Lee JM, et al. Carcinogenetic impact of alcohol intake on squamous cell carcinoma risk of the oesophagus in relation to tobacco smoking. Eur J Cancer 2007; 43: 1188-99.
176. Heeschen C, Jang JJ, Weis M, et al. Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Nat Med 2001; 7: 833-9.
177. Xu XC. COX-2 inhibitors in cancer treatment and prevention, a recent development. Anticancer Drugs 2002; 13: 127-37.
178. West KA, Brognard J, Clark AS, et al. Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. J Clin Invest 2003; 111: 81-90.
179. Moraitis D, Du B, De Lorenzo MS, et al. Levels of cyclooxygenase-2 are increased in the oral mucosa of smokers: evidence for the role of epidermal growth factor receptor and its ligands. Cancer Res 2005; 65: 664-70.
180. Hecht SS. Cigarette smoking: cancer risks, carcinogens, and mechanisms. Langenbecks Arch Surg 2006; 391: 603-13.
181. Tanaka H, Shimada Y, Harada H, et al. Methylation of the 5' CpG island of the FHIT gene is closely associated with transcriptional inactivation in esophageal squamous cell carcinomas. Cancer Res 1998; 58: 3429-34.
182. Mori M, Mimori K, Shiraishi T, et al. Altered expression of Fhit in carcinoma and precarcinomatous lesions of the esophagus. Cancer Res 2000; 60: 1177-82.
183. Morita M, Oyama T, Nakata S, et al. Expression of FHIT in esophageal epithelium and carcinoma: reference to drinking, smoking and multicentric carcinogenesis. Anticancer Res 2006; 26: 2243-8.
184. Pekarsky Y, Zanesi N, Palamarchuk A, Huebner K, Croce CM. FHIT: from gene discovery to cancer treatment and prevention. Lancet Oncol 2002; 3: 748-54.
185. Gao YT, McLaughlin JK, Blot WJ, et al. Risk factors for esophageal cancer in Shanghai, China. I. Role of cigarette smoking and alcohol drinking. Int J Cancer 1994; 58: 192-6.
186. Morita M, Kumashiro R, Kubo N, et al. Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: epidemiology, clinical findings, and prevention. Int J Clin Oncol 2010; 15: 126-34.
187. Takezaki T, Shinoda M, Hatooka S, et al. Subsite-specific risk factors for hypopharyngeal and esophageal cancer (Japan). Cancer Causes Control 2000; 11: 597-608.
188. Salaspuro V, Salaspuro M. Synergistic effect of alcohol drinking and smoking on in vivo acetaldehyde concentration in saliva. Int J Cancer 2004; 111: 480-3.
189. Kuratsune M, Kohchi S, Horie A. Carcinogenesis in the esophagus. I. Penetration of benzo(a) pyrene and other hydrocarbons into the esophageal mucosa. Gann 1965; 56: 177-87.
190. Parenti AR, Rugge M, Frizzera E, et al. p53 overexpression in the multistep process of esophageal carcinogenesis. Am J Surg Pathol 1995; 19: 1418-22.
191. Saeki H, Ohno S, Araki K, et al. Alcohol consumption and cigarette smoking in relation to high frequency of p53 protein accumulation in oesophageal squamous cell carcinoma in the Japanese. Br J Cancer 2000; 82: 1892-4.
192. Saeki H, Ohno S, Miyazaki M, et al. p53 protein accumulation in multiple oesophageal squamous cell carcinoma: relationship to risk factors. Oncology 2002; 62: 175-9.
193. Ito S, Ohga T, Saeki H, et al. p53 mutation profiling of multiple esophageal carcinoma using laser capture microdissection to demonstrate field carcinogenesis. Int J Cancer 2005; 113: 22-8.
194. Egashira A, Morita M, Kakeji Y, et al. p53 gene mutations in esophageal squamous cell carcinoma and their relevance to etiology and pathogenesis: results in Japan and comparisons with other countries. Cancer Sci 2007; 98: 1152-6.
195. Oki E, Zhao Y, Yoshida R, et al. The difference in p53 mutations between cancers of the upper and lower gastrointestinal tract. Digestion 2009; 79 (Suppl 1): 33-9.
196. Chattopadhyay I, Singh A, Phukan R, et al. Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India. Mutat Res 2010; 696: 130-8.