Clinical implications of human papillomavirus in head and neck cancers

Journal of Clinical Oncology

Volumn 24, Issue 17, 2006, Pages 2606-2611

  Fakhry, Carole ^a   Gillison, Maura L ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEMOGRAPHY; GENE MUTATION; HEAD AND NECK CANCER; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; MOLECULAR GENETICS; OROPHARYNX CANCER; PALATINE TONSIL; PRIORITY JOURNAL; PROGNOSIS; REVIEW; RISK FACTOR; SQUAMOUS CELL CARCINOMA; VIRUS INFECTION; VIRUS ONCOGENE; WART VIRUS; AGE; CLINICAL TRIAL; GENETICS; HEAD AND NECK TUMOR; HUMAN PAPILLOMAVIRUS TYPE 16; ISOLATION AND PURIFICATION; OROPHARYNX TUMOR; PATHOLOGY; SEXUAL BEHAVIOR; SMOKING; SURVIVAL; TONSIL TUMOR; VIROLOGY;

AGE FACTORS; CLINICAL TRIALS; HEAD AND NECK NEOPLASMS; HUMAN PAPILLOMAVIRUS 16; HUMANS; OROPHARYNGEAL NEOPLASMS; PAPILLOMAVIRUS INFECTIONS; RISK FACTORS; SEXUAL BEHAVIOR; SMOKING; SURVIVAL ANALYSIS; TONSILLAR NEOPLASMS;

EID: 33748155274     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2006.06.1291     Document Type: Review

References (95)

1. Schwartz SM, Daling JR, Doody DR, et al: Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection. J Natl Cancer Inst 90:1626-1636, 1998
2. Gillison ML, Koch WM, Capone RB, et al: Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 92:709-720, 2000
3. Andl T, Kahn T, Pfuhl A, et al: Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control. Cancer Res 58:5-13, 1998
4. Wiest T, Schwarz E, Enders C, et al: Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control. Oncogene 21:1510-1517, 2002
5. van Houten VM, Snijders PJ, van den Brekel MW, et al: Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas. Int J Cancer 93:232-235, 2001
6. Hafkamp HC, Speel EJ, Haesevoets A, et al: A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4A and p53 in the absence of mutations in p53 exons 5-8. Int J Cancer 107:394-400, 2003
7. Mork J, Lie AK, Glattre E, et al: Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med 344:1125-1131, 2001
8. Munoz N, Bosch FX, de Sanjose S, et al: Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 348:518-527, 2003
9. McDougall JK: Immortalization and transformation of human cells by human papillomavirus. Curr Top Microbiol Immunol 186:101-119, 1994
10. Munger K, Howley PM: Human papillomavirus immortalization and transformation functions. Virus Res 89:213-228, 2002
11. Balz V, Scheckenbach K, Gotte K, et al: Is the p53 inactivation frequency in squamous cell carcinomas of the head and neck underestimated? Analysis of p53 exons 2-11 and human papillomavirus 16/18 E6 transcripts in 123 unselected tumor specimens. Cancer Res 63:1188-1191, 2003
12. Pintos J, Franco EL, Black MJ, et al: Human papillomavirus and prognoses of patients with cancers of the upper aerodigestive tract. Cancer 85:1903-1909, 1999
13. Snijders PJ, Scholes AG, Hart CA, et al: Prevalence of mucosotropic human papillomaviruses in squamous-cell carcinoma of the head and neck. Int J Cancer 66:464-469, 1996
14. Brandwein M, Zeitlin J, Nuovo GJ, et al: HPV detection using "hot start" polymerase chain reaction in patients with oral cancer: A clinicopathological study of 64 patients. Mod Pathol 7:720-727, 1994
15. Paz IB, Cook N, Odom-Maryon T, et al: Human papillomavirus (HPV) in head and neck cancer. An association of HPV 16 with squamous cell carcinoma of Waldeyer's tonsillar ring. Cancer 79:595-604, 1997
16. Fouret P, Monceaux G, Temam S, et al: Human papillomavirus in head and neck squamous cell carcinomas in nonsmokers. Arch Otolaryngol Head Neck Surg 123:513-516, 1997
17. Ritchie JM, Smith EM, Summersgill KF, et al: Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx. Int J Cancer 104:336-344, 2003
18. Haraf DJ, Nodzenski E, Brachman D, et al: Human papilloma virus and p53 in head and neck cancer: Clinical correlates and survival. Clin Cancer Res 2:755-762, 1996
19. Nasseri M, Gage JR, Lorincz A, et al: Human papillomavirus type 16 immortalized cervical keratinocytes contain transcripts encoding E6, E7, and E2 initiated at the P97 promoter and express high levels of E7. Virology 184:131-140, 1991
20. Schwarz E, Freese UK, Gissmann L, et al: Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature 314:111-114, 1985
21. Howley PM: Role of the human papillomaviruses in human cancer. Cancer Res 51:5019s-5022s, 1991
22. Crook T, Morgenstern JP, Crawford L, et al: Continued expression of HPV-16 E7 protein is required for maintenance of the transformed phenotype of cells co-transformed by HPV-16 plus EJ-ras. Embo J 8:513-519, 1989
23. Gillison ML, Shah KV: Chapter 9: Role of mucosal human papillomavirus in nongenital cancers. J Natl Cancer Inst Monogr 57-65, 2003
24. Kreimer AR, Clifford GM, Boyle P, et al: Human papillomavirus types in head and neck squamous cell carcinomas worldwide: A systematic review. Cancer Epidemiol Biomarkers Prev 14:467-475, 2005
25. Niedobitek G, Pitteroff S, Herbst H, et al: Detection of human papillomavirus type 16 DNA in carcinomas of the palatine tonsil. J Clin Pathol 43:918-921, 1990
26. Snijders PJ, Cromme FV, van den Brule AJ, et al: Prevalence and expression of human papillomavirus in tonsillar carcinomas, indicating a possible viral etiology. Int J Cancer 51:845-850, 1992
27. Wilczynski SP, Lin BT, Xie Y, et al: Detection of human papillomavirus DNA and oncoprotein overexpression are associated with distinct morphological patterns of tonsillar squamous cell carcinoma. Am J Pathol 152:145-156, 1998
28. Mellin H, Friesland S, Lewensohn R, et al: Human papillomavirus (HPV) DNA in tonsillar cancer: Clinical correlates, risk of relapse, and survival. Int J Cancer 89:300-304, 2000
29. Klussmann JP, Gultekin E, Weissenborn SJ, et al: Expression of p16 protein identifies a distinct entity of tonsillar carcinomas associated with human papillomavirus. Am J Pathol 162:747-753, 2003
30. Strome SE, Savva A, Brissett AE, et al: Squamous cell carcinoma of the tonsils: A molecular analysis of HPV associations. Clin Cancer Res 8:1093-1100, 2002
31. Herrero R, Castellsague X, Pawlita M, et al: Human papillomavirus and oral cancer: The International Agency for Research on Cancer multicenter study. J Natl Cancer Inst 95:1772-1783, 2003
32. Snijders PJ, Meijer CJ, van den Brule AJ, et al: Human papillomavirus (HPV) type 16 and 33 E6/E7 region transcripts in tonsillar carcinomas can originate from integrated and episomal HPV DNA. J Gen Virol 73(Pt 8):2059-2066, 1992
33. Mellin H, Dahlgren L, Munck-Wikland E, et al: Human papillomavirus type 16 is episomal and a high viral load may be correlated to better prognosis in tonsillar cancer. Int J Cancer 102:152-158, 2002
34. Steenbergen RD, Hermsen MA, Walboomers JM, et al: Integrated human papillomavirus type 16 and loss of heterozygosity at 11q22 and 18q21 in an oral carcinoma and its derivative cell line. Cancer Res 55:5465-5471, 1995
35. Lindel K, Beer KT, Laissue J, et al: Human papillomavirus positive squamous cell carcinoma of the oropharynx: A radiosensitive subgroup of head and neck carcinoma. Cancer 92:805-813, 2001
36. Koskinen WJ, Chen RW, Leivo I, et al: Prevalence and physical status of human papillomavirus in squamous cell carcinomas of the head and neck. Int J Cancer 107:401-406, 2003
37. Ke LD, Adler-Storthz K, Mitchell MF, et al: Expression of human papillomavirus E7 mRNA in human oral and cervical neoplasia and cell lines. Oral Oncol 35:415-420, 1999
38. Begum S, Gillison ML, Ansari-Lari MA, et al: Detection of human papillomavirus in cervical lymph nodes: A highly efffective strategy for localizing site of tumor origin in patients with metastatic squamous cell carcinoma of the head and neck. Clin Cancer Res 9:6469-6475, 2003
39. Brachman DG, Graves D, Vokes E, et al: Occurrence of p53 gene deletions and human papilloma virus infection in human head and neck cancer. Cancer Res 52:4832-4836, 1992
40. Chiba I, Shindoh M, Yasuda M, et al: Mutations in the p53 gene and human papillomavirus infection as significant prognostic factors in squamous cell carcinomas of the oral cavity. Oncogene 12:1663-1668, 1996
41. Smeets SJ, Braakhuis BJ, Abbas S, et al: Genome-wide DNA copy number alterations in head and neck squamous cell carcinomas with or without oncogene-expressing human papillomavirus. Oncogene, November 28, 2005 [epub ahead of print]
42. Braakhuis BJ, Snijders PJ, Keune WJ, et al: Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus. J Natl Cancer Inst 96:998-1006, 2004
43. Sisk EA, Soltys SG, Zhu S, et al: Human papillomavirus and p53 mutational status as prognostic factors in head and neck carcinoma. Head Neck 24:841-849, 2002
44. Cruz IB, Snijders PJ, Steenbergen RD, et al: Age-dependence of human papillomavirus DNA presence in oral squamous cell carcinomas. Eur J Cancer B Oral Oncol 32B:55-62, 1996
45. Ringstrom E, Peters E, Hasegawa M, et al: Human papillomavirus type 16 and squamous cell carcinoma of the head and neck. Clin Cancer Res 8:3187-3192, 2002
46. Brandsma JL, Abramson AL: Association of papillomavirus with cancers of the head and neck. Arch Otolaryngol Head Neck Surg 115:621-625, 1989
47. Klussmann JP, Weissenborn SJ, Wieland U, et al: Human papillomavirus-positive tonsillar carcinomas: A different tumor entity? Med Microbiol Immunol (Berl) 192:129-132, 2003
48. Zoltan S, Szabolcs O, Miklos K: Indications for molecular detection of human papillomavirus (HPV) [in Hungarian]. Magy Onkol 46:235-237, 2002
49. El-Mofty SK, Lu DW: Prevalence of human papillomavirus type 16 DNA in squamous cell carcinoma of the palatine tonsil, and not the oral cavity, in young patients: A distinct clinicopathologic and molecular disease entity. Am J Surg Pathol 27:1463-1470, 2003
50. Poetsch M, Lorenz G, Bankau A, et al: Basaloid in contrast to nonbasaloid head and neck squamous cell carcinomas display aberrations especially in cell cycle control genes. Head Neck 25:904-910, 2003
51. Portugal LG, Goldenberg JD, Wenig BL, et al: Human papillomavirus expression and p53 gene mutations in squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 123:1230-1234, 1997
52. Gillison ML, Lowy DR: A causal role for human papillomavirus in head and neck cancer. Lancet 363:1488-1489, 2004
53. Smith EM, Ritchie JM, Summersgill KF, et al: Human papillomavirus in oral exfoliated cells and risk of head and neck cancer. J Natl Cancer Inst 96:449-455, 2004
54. Kjaer SK, Chackerian B, van den Brule AJ, et al: High-risk human papillomavirus is sexually transmitted: Evidence from a follow-up study of virgins starting sexual activity (intercourse). Cancer Epidemiol Biomarkers Prev 10:101-106, 2001
55. Rosenquist K, Wennerberg J, Schildt EB, et al: Oral status, oral infections and some lifestyle factors as risk factors for oral and oropharyngeal squamous cell carcinoma. A population-based case-control study in southern Sweden. Acta Otolaryngol 125:1327-1336, 2005
56. Rajkumar T, Sridhar H, Balaram P, et al: Oral cancer in Southern India: The influence of body size, diet, infections and sexual practices. Eur J Cancer Prev 12:135-143, 2003
57. Smith EM, Ritchie JM, Summersgill KF, et al: Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers. Int J Cancer 108:766-772, 2004
58. Maden C, Beckmann AM, Thomas DB, et al: Human papillomaviruses, herpes simplex viruses, and the risk of oral cancer in men. Am J Epidemiol 135:1093-1102, 1992
59. Hansson BG, Rosenquist K, Antonsson A, et al: Strong association between infection with human papillomavirus and oral and oropharyngeal squamous cell carcinoma: A population-based case-control study in southern Sweden. Acta Otolaryngol 125:1337-1344, 2005
60. Kreimer AR, Alberg AJ, Daniel R, et al: Oral human papillomavirus infection in adults is associated with sexual behavior and HIV serostatus. J Infect Dis 189:686-698, 2004
61. Coutlee F, Trottier AM, Ghattas G, et al: Risk factors for oral human papillomavirus in adults infected and not infected with human immunodeficiency virus. Sex Transm Dis 24:23-31, 1997
62. Frisch M, Biggar RJ: Aetiological parallel between tonsillar and anogenital squamous-cell carcinomas. Lancet 354:1442-1443, 1999
63. Hemminki K, Jiang Y, Dong C: Second primary cancers after anogenital, skin, oral, esophageal and rectal cancers: Etiological links? Int J Cancer 93:294-298, 2001
64. Frisch M, Biggar RJ, Goedert JJ: Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome. J Natl Cancer Inst 92:1500-1510, 2000
65. Kutler DI, Auerbach AD, Satagopan J, et al: High incidence of head and neck squamous cell carcinoma in patients with Fanconi anemia. Arch Otolaryngol Head Neck Surg 129:106-112, 2003
66. Lowy D, Gillison ML: New link between Fanconi Anemia and human papillomavirus associated malignancies. J Natl Cancer Inst 95:1648-1650, 2003
67. Fleming DT, McQuillan GM, Johnson RE, et al: Herpes simplex virus type 2 in the United States, 1976 to 1994. N Engl J Med 337:1105-1111, 1997
68. Af Geijersstam V, Wang Z, Lewensohn-Fuchs I, et al: Trends in seroprevalence of human papillomavirus type 16 among pregnant women in Stockholm, Sweden, during 1969-1989. Int J Cancer 76:341-344, 1998
69. Frisch M, Hjalgrim H, Jaeger AB, et al: Changing patterns of tonsillar squamous cell carcinoma in the United States. Cancer Causes Control 11:489-495, 2000
70. Shiboski CH, Schmidt BL, Jordan RC: Tongue and tonsil carcinoma: Increasing trends in the U.S. population ages 20-44 years. Cancer 103:1843-1849, 2005
71. Canto MT, Devesa SS: Oral cavity and pharynx cancer incidence rates in the United States, 1975-1998. Oral Oncol 38:610-617, 2002
72. Koch WM, Bhatti N, Williams MF, et al: Oncologic rationale for bilateral tonsillectomy in head and neck squamous cell carcinoma of unknown primary source. Otolaryngol Head Neck Surg 124:331-333, 2001
73. McQuone SJ, Eisele DW, Lee DJ, et al: Occult tonsillar carcinoma in the unknown primary. Laryngoscope 108:1605-1610, 1998
74. Mendenhall WM, Mancuso AA, Parsons JT, et al: Diagnostic evaluation of squamous cell carcinoma metastatic to cervical lymph nodes from an unknown head and neck primary site. Head Neck 20:739-744, 1998
75. Lapeyre M, Malissard L, Peiffert D, et al: Cervical lymph node metastasis from an unknown primary: Is a tonsillectomy necessary? Int J Radiat Oncol Biol Phys 39:291-296, 1997
76. Li W, Thompson CH, O'Brien CJ, et al: Human papillomavirus positivity predicts favourable outcome for squamous carcinoma of the tonsil. Int J Cancer 106:553-558, 2003
77. Schwartz SR, Yueh B, McDougall JK, et al: Human papillomavirus infection and survival in oral squamous cell cancer: A population-based study. Otolaryngol Head Neck Surg 125:1-9, 2001
78. Weinberger PM, Yu Z, Haffty BG, et al: Molecular classification identifies a subset of human papillomavirus-associated oropharyngeal cancers with favorable prognosis. J Clin Oncol 24:736-747, 2006
79. DeWeese TL, Walsh JC, Dillehay LE, et al: Human papillomavirus E6 and E7 oncoproteins alter cell cycle progression but not radiosensitivity of carcinoma cells treated with low-dose-rate radiation. Int J Radiat Oncol Biol Phys 37:145-154, 1997
80. Mellin Dahlstrand H, Lindquist D, Bjornestal L, et al: P16(INK4a) correlates to human papillomavirus presence, response to radiotherapy and clinical outcome in tonsillar carcinoma. Anticancer Res 25:4375-4383, 2005
81. Butz K, Whitaker N, Denk C, et al: Induction of the p53-target gene GADD45 in HPV-positive cancer cells. Oncogene 18:2381-2386, 1999
82. Huang H, Li CY, Little JB: Abrogation of P53 function by transfection of HPV16 E6 gene does not enhance resistance of human tumour cells to ionizing radiation. Int J Radiat Biol 70:151-160, 1996
83. Ferris RL, Martinez I, Sirianni N, et al: Human papillomavirus-16 associated squamous cell carcinoma of the head and neck (SCCHN): A natural disease model provides insights into viral carcinogenesis. Eur J Cancer 41:807-815, 2005
84. Hsu KF, Hung CF, Cheng WF, et al: Enhancement of suicidal DNA vaccine potency by inking mycobacterium tumberculosis heat shock protein 70 to an antigen. Gene Ther 8:376-383, 2001
85. Harper DM, Franco EL, Wheeler C, et al: Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: A randomised controlled trial. Lancet 364:1757-1765, 2004
86. Koutsky LA, Ault KA, Wheeler CM, et al: A controlled trial of a human papillomavirus type 16 vaccine. N Engl J Med 347:1645-1651, 2002
87. Maeda H, Kubo K, Sugita Y, et al: DNA vaccine against hamster oral papillomavirus-associated oral cancer. J Int Med Res 33:647-653, 2005
88. Johnston KB, Monteiro JM, Schultz LD, et al: Protection of beagle dogs from mucosal challenge with canine oral papillomavirus by immunization with recombinant adenoviruses expressing codon-optimized early genes. Virology 336:208-218, 2005
89. Lizard G, Demares-Poulet MJ, Roignot P, et al: In situ hybridization detection of single-copy human papillomavirus on isolated cells, using a catalyzed signal amplification system: GenPoint. Diagn Cytopathol 24:112-116, 2001
90. Gravitt PE, Peyton C, Wheeler C, et al: Reproducibility of HPV 16 and HPV 18 viral load quantitation using TaqMan real-time PCR assays. J Virol Methods 112:23-33, 2003
91. Ha PK, Pai SI, Westra WH, et al: Real-time quantitative PCR demonstrates low prevalence of human papillomavirus type 16 in premalignant and malignant lesions of the oral cavity. Clin Cancer Res 8:1203-1209, 2002
92. Capone RB, Pai SI, Koch WM, et al: Detection and quantitation of human papillomavirus (HPV) DNA in the sera of patients with HPV-associated head and neck squamous cell carcinoma. Clin Cancer Res 6:4171-4175, 2000
93. Veltman JA, Hopman AH, Bot FJ, et al: Detection of chromosomal aberrations in cytologic brush specimens from head and neck squamous cell carcinoma. Cancer 81:309-314, 1997
94. Herrero R, Catellsague X, Munoz N, et al. Multicentric case-control study of HPV and oral cancer. Presented at the 20th International Papillomavirus Conference, Paris, France, October 4-9, 2002
95. Zumbach K, Kisseljov F, Sacharova O, et al: Antibodies against oncoproteins E6 and E7 of human papillomavirus types 16 and 18 in cervical-carcinoma patients from Russia. Int J Cancer 85:313-318, 2000