DNA damage caused by metal nanoparticles: Involvement of oxidative stress and activation of ATM

Chemical Research in Toxicology

Volumn 25, Issue 7, 2012, Pages 1402-1411

  Wan, Rong ^a   Mo, Yiqun ^a   Feng, Lingfang ^a   Chien, Sufan ^b   Tollerud, David J ^a   Zhang, Qunwei ^a  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 6 (1 THIANTHRENYL) 4 PYRANONE; 8 HYDROXYDEOXYGUANOSINE; ACETYLCYSTEINE; ATM PROTEIN; CATALASE; COBALT NANOPARTICLE; HISTONE H2AX; METAL NANOPARTICLE; PROTEIN P53; RAD51 PROTEIN; REACTIVE OXYGEN METABOLITE; SCAVENGER; TITANIUM DIOXIDE NANOPARTICLE; UNCLASSIFIED DRUG;

CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DNA CONTENT; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; GENOTOXICITY; HISTONE PHOSPHORYLATION; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ACETYLCYSTEINE; CATALASE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; COBALT; DNA; DNA DAMAGE; DNA-BINDING PROTEINS; HISTONES; HUMANS; METAL NANOPARTICLES; MORPHOLINES; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PYRONES; RAD51 RECOMBINASE; REACTIVE OXYGEN SPECIES; TITANIUM; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

ATAXIA TELANGIECTASIA;

EID: 84863891460     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx200513t     Document Type: Conference Paper

References (46)

1. Chow, J. C., Watson, J. G., Savage, N., Solomon, C. J., Cheng, Y. S., McMurry, P. H., Corey, L. M., Bruce, G. M., Pleus, R. C., Biswas, P., and Wu, C. Y. (2005) Nanoparticles and the environment J. Air Waste Manage. Assoc. 55, 1411-1417
2. Colvin, V. L. (2003) The potential environmental impact of engineered nanomaterials Nat. Biotechnol. 21, 1166-1170
3. Owen, R. and Depledge, M. (2005) Nanotechnology and the environment: risk and rewards Mar. Pollut. Bull. 50, 609-612
4. Oberdorster, G., Oberdoster, E., and Oberdorster, L. (2005) Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles Environ. Health Perspect. 113, 823-839
5. Xia, T., Li, N., and Nel, A. E. (2009) Potential health impact of nanoparticles Annu. Rev. Public Health. 30, 137-150
6. Valko, M., Morris, H., and Cronin, M. T. D. (2005) Metal, toxicity, and oxidative stress Curr. Med. Chem. 12, 1161-1208
7. Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., and Mazur, M. (2006) Free radicals, metals and antioxidants in oxidative stress-induced cancer Chem.-Biol. Interact. 160, 1-40
8. Gonealez Lison, D. and Krisch-Volders, M. (2008) Genotoxicity of engineered nanomaterials: a critical review Nanotoxicology 2, 252-273
9. Landsiedel, R., Kapp, M. D., Schulz, M., Wiench, K., and Oesch, F. (2009) Genotoxicity investigation on nanomaterials: methods, preparation and characterization of test material, potential artifacts and limitations-many questions, some answers Mutat. Res. 681, 541-528
10. Wang, K., Xu, J. J., and Chen, H. Y. (2005) A novel glucose biosensor based on the nanoscaled cobalt phthalocyanine glucose oxidase biocomposite Biosens. Bioelectron. 20, 1388-1396
11. Yang, M. H., Jiang, J. H., Yang, Y. H., Chen, X. H., Shen, G. L., and Yu, R. Q. (2006) Carbon nanotube/cobalt hexacyanoferrate nanoparticle-biopolymer system for the fabrication of biosensors Biosens. Bioelectron. 21, 1791-1797
12. Galanis, A., Karapetsas, A., and Sandaltzopoulos, R. (2009) Metal-induced carcinogenesis, oxidative stress and hypoxia signaling Mutat. Res. 674, 31-35
13. Pulido, M. D. and Parrish, A. R. (2003) Metal-induced apoptosis: mechanism Mutat. Res. 533, 227-241
14. Risom, L., Moller, P., and Loft, S. (2005) Oxidative stress-induced DNA damage by particulate air pollution Mutat. Res. 592, 119-137
15. Barchowsky, A. and O'Hara, K. A. (2003) Metal-induced cell signaling and gene activation in lung disease Free Radical Biol. Med 34, 1130-1135
16. Banin, S., Moyal, L., Shieh, S., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., and Ziv, Y. (1998) Enhanced phosphorylation of p53 by ATM in response to DNA damage Science 81, 1674-1677
17. Suzuki, K., Inageda, K., Nishitai, G., and Matsuoka, M. (2007) Phosphorylation of p53 at serine 15 A549 pulmonary epithelail cells exposure to vanadate: involvement of ATM pathway Toxicol. Appl. Pharmacol. 220, 83-91
18. Vousden, K. H. and Lane, D. P. (2007) P53 in health and disease Nat. Rev. Mol. Cell Biol. 8, 275-283
19. Zhao, H., Traganos, F., and Darzynkiewicz, Z. (2008) Phosphorylation p53 on Ser 15 during cell cycle caused by Topo I and Topo II inhibitor in relation to ATM and Chk2 activation Cell Cycle 7, 3048-3055
20. Lavin, M. F. and Kozlov, S. (2007) ATM activation and DNA damage response Cell Cycle 6, 931-942
21. Tanaka, T., Halicka, X. D., Huang, X., Traganos, F., and Darzynkiewicz, Z. (2006) Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants Cell Cycle 5, 1940-1945
22. Kurz, E. U. and Lees-Miller, S. P. (2004) DNA damage-induced activation of ATM and ATM-dependent signaling pathways DNA Repair 3, 889-900
23. De Boeck, M., Krisch-Volders, M., and Lison, D. (2003) Cobalt and antimony: genotoxicity and carcinogenicity Mutat. Res. 533, 135-152
24. De Boeck, M., Hoet, P., Lombaert, N., Nemery, B., Kirsch-Volders, M., and Lison, D. (2003) In vivo genotoxicity of hard metal dust: induction of micronuclei in rat type II epithelial lung cells Carcinogenesis 24, 1793-1800
25. Colognato, R., Bonelli, A., Ponti, J., Farina, M., Bergamaschi, E., Sabbioni, E., and Migliore, L. (2008) Comparative genotoxicity of cobalt nanoparticles and ions on human peripheral leukocytes in vitro Mutagenesis 23, 377-382
26. Hoeijmakers, J., H. (2001) Genome maintenance mechanisms for preventing cancer Nature 411, 366-374
27. IARC Working Group (1992) Cobalt and Cobalt Compounds, in IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man, Vol. 52, pp 263-473, IARC, Lyon, France.
28. Karlsson, H. L. (2010) The Comet assay in nanotoxicology research Anal. Bioanal. Chem. 398, 651-666
29. Ponti, J., Sabbioni, E., Munaro, B., Broggi, F., Marmorato, P., Franchini, F., Colognato, R., and Rossi, F. (2009) Genotoxicity and morphological transformation induced by cobalt nanoparticles and cobalt chloride: an in vitro study in Balb/3T3 mouse fibroblasts Mutagenesis 24, 439-445
30. Lison, D., De Boeck, M., Verougstraete, V., and Kirsch-Volders, M. (2001) Update on the genotoxicity and carcinogenicity of cobalt compounds Occup. Environ. Med. 58, 619-625
31. Sedelnikova, O. A., Pilch, D. R., Redon, C., and Bonner, W. M. (2003) Histone H2AX in DNA damage and repair Cancer Biol. Ther. 2, 233-235
32. Mah, L. J., El-Osta, A., and Karagiannis, T. C. (2010) GammaH2AX as a molecular marker of aging and disease Epigenetics 5, 129-136
33. Mah, L. J., El-Osta, A., and Karagiannis, T. C. (2010) GammaH2AX: a sensitive molecular marker of DNA damage and repair Leukemia 24, 679-686
34. Paull, T. T., Rogakou, E. P., Yamazaki., V., Kirchgessner, C. U., Gellert, M., and Bonner, W. M. (2000) A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage Curr. Biol. 10, 886-895
35. Shieh, S. Y., Ikeda, M., Taya, Y., and Prives, C. (1997) DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2 Cell 3191, 325-334
36. Siliciano, J. D., Canman, C. E., Taya, Y., Sakaguchi, K., Appella, E., and Kastan, M. B. (1997) DNA damage induces phosphorylation of the amino terminus of p53 Genes. Dev. 11, 3471-3481
37. Ismail, I. H., Nyström, S., Nygren, J., and Hammarsten, O. (2005) Activation of ataxia telangiectasia mutated by DNA strand break-inducing agents correlates closely with the number of DNA double strand breaks J. Biol. Chem. 280, 4649-4655
38. Xie, H., Wise, S. S., Holmes, A. L., Xu, B., Wakeman, T. P., Pelsue, S. C., Singh, N. P., and Wise, J. P., Sr. (2005) Carcinogenic lead chromate induces DNA double-strand breaks in human lung cells Mutat. Res. 586, 160-172
39. Canman, C. E., Lim, D. S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., and Siliciano, J. D. (1998) Activation of the ATM kinase by ionizing radiation and phosphorylation of p53 Science 281, 1677-1679
40. Kyono, H., Kusaka, Y., Homma, K., Kubota, H., and Endo-ichikawa, Y. (1992) Reversible lung lesions in rats due to short-term exposure to ultrafine cobalt particles Ind. Health 30, 103-118
41. Wan, R., Mo, Y., Chien, S., Li, Y., Li, Y., Tollerud, D. J., and Zhang, Q. (2011) The role of hypoxia inducible factor-1α in MMP-2 and MMP-9 production by human monocytes exposed to nickel nanoparticles Nanotoxicology 5 (4) 568-582
42. Yu, M., Mo, Y., Wan, R., Chien, S., Zhang, X., and Zhang, Q. (2010) Regulation of plasminogen activator inhibitor-1 expression in endothelial cells with exposure to metal nanoparticles Toxicol. Lett. 195, 82-89
43. Mo, Y., Wan, R., Wang, J., Chien, S., Tollerud, D. J., and Zhang, Q. (2009) Diabetes is associated with increased sensitivity of alveolar macrophages to urban particulate matter exposure Toxicology 262, 130-137
44. Wan, R., Mo, Y., Zhang, X., Chien, S., Tollerud, D. J., and Zhang, Q. (2008) Matrix metalloproteinase-2 and -9 are induced differently by metal nanoparticles in human monocytes: the role of oxidative stress and protein tyrosine kinase activation Toxicol. Appl. Pharmacol. 233, 276-285
45. Gojova, A., Guo, B., Kota, R. S., Rutledge, J. C., Kennedy, I. M., and Barakat, A. I. (2007) Induction of inflammation in vascular endothelial cells by metal oxide nanoparticles: effect of particle composition Environ. Health Perspect. 115, 403-409
46. Cho, E. C., Zhang, Q., and Xia, Y. (2011) The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles Nat. Nanotechnol. 6 (6) 385-391