Metal-induced carcinogenesis, oxidative stress and hypoxia signalling

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 674, Issue 1-2, 2009, Pages 31-35

  Galanis, Alex ^a   Karapetsas, Athanasios ^a   Sandaltzopoulos, Raphael ^a  

^a Molecular Diagnosis and Modern Therapeutics   (Greece)

Author keywords

Cancer; Heavy metal; HIF 1 signalling; Oxidative stress; Reactive oxygen species

Indexed keywords

ARSENIC; CHROMIUM; COBALT; GEFITINIB; HEAVY METAL; NICKEL; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; TRASTUZUMAB; VANADIUM;

CANCER GROWTH; CARCINOGENESIS; CELL HYPOXIA; HUMAN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ARSENIC; CARCINOGENS, ENVIRONMENTAL; CELL HYPOXIA; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; METALS, HEAVY; MODELS, BIOLOGICAL; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 61649084200     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2008.10.008     Document Type: Review

References (42)

1. Valko M., Morris H., and Cronin M. Metals, toxicity and oxidative stress. Curr. Med. Chem. 12 (2005) 1161-1208
2. Salnikow K., and Zhitkovich A. Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium. Chem. Res. Toxicol. 21 (2008) 28-44
3. Leonard S., Bower J., and Shi X. Metal-induced toxicity, carcinogenesis, mechanisms and cellular responses. Mol. Cell. Biochem. 255 (2004) 3-10
4. Ke Q., and Costa M. Hypoxia-inducible factor-1 (HIF-1). Mol. Pharmacol. 70 (2006) 1469-1480
5. Galanis A., Pappa A., Giannakakis A., Lanitis E., Dangaj D., and Sandaltzopoulos R. Reactive oxygen species and HIF-1 signalling in cancer. Cancer Lett. 266 (2008) 12-20
6. Valko M., Rhodes C., Moncol J., Izakovic M., and Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem. Biol. Interact. 160 (2006) 1-40
7. Valko M., Leibfritz D., Moncol J., Cronin M., Mazur M., and Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 39 (2007) 44-84
8. Thannickal V., and Fanburg B. Reactive oxygen species in cell signaling. Am. J. Physiol. Lung Cell Mol. Physiol. 279 (2000) 1005-1028
9. Yang S.H., Sharrocks A., and Whitmarsh A. Transcriptional regulation by the MAP kinase signaling cascades. Gene 320 (2003) 3-21
10. Sang N., Stiehl D., Bohensky J., Leshchinsky I., Srinivas V., and Caro J. MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300. J. Biol. Chem. 278 (2003) 14013-14019
11. Mylonis I., Chachami G., Samiotaki M., Panayotou G., Paraskeva E., Kalousi A., Georgatsou E., Bonanou S., and Simos G. Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1alpha. J. Biol. Chem. 281 (2006) 33095-33106
12. Rezvani H., Dedieu S., North S., Belloc F., Rossignol R., Letellier T., de Verneuil H., Taieb A., and Mazurier F. Hypoxia-inducible factor-1α, a key factor in the keratinocyte response to UVB exposure. Toxicol. Appl. Pharmacol. 282 (2007) 16413-16422
13. International Agency for Research on Cancer (IARC). Nickel and nickel compounds. Summ. Eval. 49 (1990) 257
14. Ke Q., Davidson T., Chen H., Kluz T., and Costa M. Alterations of histone modifications and transgene silencing by nickel chloride. Carcinogenesis 27 (2006) 1481-1488
15. Costa M., Davidson T., Chen H., Ke Q., Zhang P., Yan Y., Huang C., and Kluz T. Nickel carcinogenesis: epigenetics and hypoxia signaling. Mut. Res./Fundamental Mol. Mechanisms Mutagen. 592 (2005) 79-88
16. Chen H., Ke Q., Kluz T., Yan Y., and Costa M. Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing. Mol. Cell. Biol. 26 (2006) 3728-3737
17. Maxwell P., and Salnikow K. HIF-1: an oxygen and metal responsive transcription factor. Cancer Biol. Ther. 3 (2004) 29-35
18. Davidson T., Chen H., Di Toro D., D'Angelo G., and Costa M. Soluble nickel inhibits HIF-Prolyl-Hydroxylases creating persistent hypoxic signaling in A549 cells. Mol. Carcinog. 45 (2006) 479-489
19. Salnikow K., Donald S., Bruick R., Zhitkovich A., Phang J., Kasprzak K., and Kazimierz S. Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress. J. Biol. Chem. 279 (2004) 40337-40344
20. Karaczyn A., Ivanov S., Reynolds M., Zhitkovich A., Kasprzak K., and Salnikow K. Ascorbate depletion mediates up-regulation of hypoxia-associated proteins by cell density and nickel. J. Cell. Biochem. 97 (2006) 1025-1035
21. International Agency for Research on Cancer (IARC). Cobalt and cobalt compounds. Summ. Eval. 52 (1991) 363
22. Salnikow K., Su W., Blagosklonny M., and Costa M. Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism. Cancer Res. 60 (2000) 3375-3378
23. Chachami G., Simos G., Hatziefthimiou A., Bonanou S., Molyvdas P., and Paraskeva E. Cobalt induces hypoxia-inducible factor-1α expression in airway smooth muscle cells by a reactive oxygen species- and PI3K-dependent mechanism. Am. J. Respir. Cell Mol. Biol. 31 (2004) 544-551
24. Mukherjee B., Patra B., Mahapatra S., Banerjee P., Tiwari A., and Chatterjee M. Vanadium-an element of atypical biological significance. Toxicol. Lett. 150 (2004) 135-143
25. Caicedo M., Jacobs J., Reddy A., and Hallab N. Analysis of metal ion-induced DNA damage, apoptosis, and necrosis in human (Jurkat) T-cells demonstrates Ni(2+) and V(3+) are more toxic than other metals: Al(3+), Be(2+), Co(2+), Cr(3+), Cu(2+), Fe(3+), Mo(5+), Nb(5+), Zr(2+). J. Biomed. Mater. Res. A 86 (2008) 905-913
26. International Agency for Research on Cancer (IARC). Vanadium pentoxide. IARC Monogr. Eval. Carcinog. Risks Hum. 86 (2003) 227-243
27. Gao N., Ding M., Zheng J., Zhang Z., Leonard S., Liu K., Shi X., and Jiang B. Vanadate-induced expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species. J. Biol. Chem. 277 (2002) 31963-31971
28. Hwang J., Lee M., Jung S., Lee H., Kang I., Kim S., and Ha J. AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1α expression in DU145 cells. Carcinogenesis 25 (2004) 2497-2507
29. Waalkes M., Liu J., Ward J., and Diwan B. Mechanisms underlying arsenic carcinogenesis: hypersensitivity of mice exposed to inorganic arsenic during gestation. Toxicology 198 (2004) 31-38
30. International Agency for Research on Cancer (IARC). Arsenic and arsenic compounds. Summ. Eval. 7 (1987) 100
31. Simeonova P., Wang S., Toriuma W., Kommineni V., Matheson J., Unimye N., Kayama F., Harki D., Ding M., Vallyathan V., and Luster M. Arsenic mediates cell proliferation and gene expression in the bladder epithelium: association with activating protein-1 transactivation. Cancer Res. 60 (2000) 3445-3453
32. Shi H., Shi X., and Liu K. Oxidative mechanism of arsenic toxicity and carcinogenesis. Mol. Cell. Biochem. 255 (2004) 67-78
33. Huang C., Ke Q., Costa M., and Shi X. Molecular mechanisms of arsenic carcinogenesis. Mol. Cell. Biochem. 255 (2004) 57-66
34. Shen G., Zhang Z., Leonard S., He H., Zhang X., Shi X., and Jiang B. Arsenite induces HIF-1α and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells. Mol. Cell. Biochem. 255 (2004) 33-45
35. Skinner H., Zhong X., Gao N., Shi X., and Jiang B. Arsenite induces p70S6K1 activation and HIF-1α expression in prostate cancer cells. Mol. Cell. Biochem. 255 (2004) 19-23
36. Kamat C., Green D., Curilla S., Warnke L., Hamilton J., Sturup S., Clark C., and Ihnat M. Role of HIF signaling on tumorigenesis in response to chronic low-dose arsenic administration. Toxicol. Sci. 86 (2005) 248-257
37. International Agency for Research on Cancer (IARC). Chromium, nickel and welding. IARC Monogr. Eval. Carcinog. Risks Hum. 49 (1990) 49-256
38. Ding M., and Shi X. Molecular mechanisms of Cr(VI)-induced carcinogenesis. Mol. Cell. Biochem. 234/235 (2002) 293-300
39. Beyersmann D., and Hartwig A. Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms. Arch. Toxicol. (2008) 493-512
40. Gao N., Jiang B., Leonard S., Corum L., Zhang Z., Roberts J., Antonini J., Zheng J., Flynn D., Castranova V., and Shi X. p38 Signaling-mediated hypoxia-inducible factor 1alpha and vascular endothelial growth factor induction by Cr(VI) in DU145 human prostate carcinoma cells. J. Biol. Chem. 277 (2002) 45041-45048
41. Mabjeesh N., Post D., Willard M., Kaur B., Van Meir E., Simons J., and Zhong H. Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteasome pathway in prostate cancer cells. Cancer Res. 62 (2002) 2478-2482
42. Welsh S., Williams R., Kirkpatrick L., Paine-Murrieta G., and Powis G. Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Mol. Cancer Ther. 3 (2004) 233-244