An automated flow for directed evolution based on detection of promiscuous scaffolds using spatial and electrostatic properties of catalytic residues

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Chakraborty, Sandeep ^a  

^a TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE; LEUKOCYTE ELASTASE; PENICILLIN BINDING PROTEIN;

ANALYTIC METHOD; ARTICLE; AUTOMATION; CALCULATION; CONTROLLED STUDY; DIRECTED EVOLUTION USING CLASP AN AUTOMATED FLOW; ENZYME ACTIVITY; NONHUMAN; PROTEIN STRUCTURE; PROTEIN TARGETING; SCORING SYSTEM; SITE DIRECTED MUTAGENESIS; STATIC ELECTRICITY; STEREOCHEMISTRY;

AMINO ACID MOTIFS; AUTOMATION, LABORATORY; BETA-LACTAMASES; CATALYTIC DOMAIN; COMPUTATIONAL BIOLOGY; DIRECTED MOLECULAR EVOLUTION; ESCHERICHIA COLI PROTEINS; MODELS, MOLECULAR; PANCREATIC ELASTASE; PENICILLIN-BINDING PROTEINS; STATIC ELECTRICITY;

EID: 84863836923     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040408     Document Type: Article

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