The promise and peril of continuous in vitro evolution

Journal of Molecular Evolution

Volumn 61, Issue 2, 2005, Pages 253-263

  Johns, Glenn C ^a   Joyce, Gerald F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Continuous evolution; In vitro evolution; Isothermal amplification; Ligase; Mutation; Ribozyme; Selection

Indexed keywords

COMPLEMENTARY DNA; DNA POLYMERASE; NUCLEIC ACID; PRIMER DNA; RIBONUCLEASE H; RIBOZYME; RNA POLYMERASE;

AMINO ACID SEQUENCE; CATALYSIS; DNA RNA HYBRIDIZATION; DNA STRAND; DNA STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; GENE CONSTRUCT; GENETIC DRIFT; IN VITRO SELECTION; INBREEDING; MOLECULAR EVOLUTION; MOLECULAR RECOGNITION; NUCLEIC ACID AMPLIFICATION; PH MEASUREMENT; POLYMERASE CHAIN REACTION; PROMOTER REGION; REVERSE TRANSCRIPTION; REVIEW; RNA METABOLISM; SEQUENCE ANALYSIS; STOCHASTIC MODEL; THERMOSTABILITY;

DIRECTED MOLECULAR EVOLUTION; LIGASES; NUCLEIC ACID CONFORMATION; RNA, CATALYTIC;

CANDIDA;

EID: 24744453533     PISSN: 00222844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00239-004-0307-1     Document Type: Review

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