Crystal structure of wild-type penicillin-binding protein 5 from Escherichia coli: Implications for deacylation of the acyl-enzyme complex

Journal of Biological Chemistry

Volumn 278, Issue 52, 2003, Pages 52826-52833

  Nicholas, Robert A ^a   Krings, Sandra ^b   Tomberg, Joshua ^a   Nicola, George ^b   Davies, Christopher ^b,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c CB 7365 Mary Ellen Jones Bldg ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLATION; ANTIBIOTICS; CRYSTAL STRUCTURE; ENZYMES; ESCHERICHIA COLI; HYDROGEN BONDS; HYDROLYSIS; MUTAGENESIS;

CELL WALL; MUTATIONS;

BIOCHEMISTRY;

ACYL COENZYME A; ASPARAGINE; ASPARTIC ACID; BACTERIAL PROTEIN; BETA LACTAM ANTIBIOTIC; GLYCINE; PENICILLIN BINDING PROTEIN; PENICILLIN BINDING PROTEIN 5; SERINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEACYLATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE MUTATION; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN HYDROLYSIS; PROTEIN MOTIF; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

AMINO ACID MOTIFS; BACTERIAL PROTEINS; BINDING SITES; CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; GENE DELETION; HEXOSYLTRANSFERASES; HYDROGEN BONDING; HYDROLYSIS; KINETICS; LYSINE; MODELS, MOLECULAR; MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; MUTATION; PENICILLIN-BINDING PROTEINS; PEPTIDYL TRANSFERASES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; X-RAY DIFFRACTION;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0347362788     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M310177200     Document Type: Article

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