N-Substituted-2′-O,3′-N-carbonimidoyl bridged macrolides: Novel anti-inflammatory macrolides without antimicrobial activity

Journal of Medicinal Chemistry

Volumn 55, Issue 13, 2012, Pages 6111-6123

  Bosnar, Martina ^a   Kragol, Goran ^a   Koštrun, Sanja ^a   Vujasinović, Ines ^a   Bošnjak, Berislav ^a   Bencetić Mihaljević, Vlatka ^a   Marušić Ištuk, Zorica ^a   Kapić, Samra ^a   Hrvačić, Boška ^a   Brajša, Karmen ^a   Tavčar, Branka ^a   Jelić, Dubravko ^a   Glojnarić, Ines ^a   Verbanac, Donatella ^a   Čulić, Ognjen ^a   Padovan, Jasna ^a   Alihodžić, Sulejman ^a   Eraković Haber, Vesna ^a   Spaventi, Radan ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2' O,3' N (N' ETHYLCARBONIMIDOYL) 3'N DEMETHYL 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 2' O,3' N (N' ISOPROPYLCARBONIMIDOYL) 3'N DEMETHYL 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; AZITHROMYCIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MACROLIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACTERIAL INFECTION; BIOAVAILABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG HALF LIFE; DRUG STRUCTURE; DRUG SYNTHESIS; HAEMOPHILUS INFLUENZAE; HUMAN; HUMAN CELL; IMMUNOMODULATION; INFLAMMATION; LUNG LAVAGE; MALE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR LIBRARY; MORAXELLA CATARRHALIS; MOUSE; NEUTROPHILIA; NONHUMAN; RAT; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PYOGENES; SUBSTITUTION REACTION;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AZITHROMYCIN; BRONCHIOLITIS; BRONCHOALVEOLAR LAVAGE FLUID; CELL LINE; CLARITHROMYCIN; CYSTIC FIBROSIS; DRUG INTERACTIONS; DRUG RESISTANCE, BACTERIAL; ERYTHROMYCIN; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HUMANS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LUNG; MACROLIDES; MALE; MICE; MICE, INBRED BALB C; MICROBIAL SENSITIVITY TESTS; MORAXELLA (BRANHAMELLA) CATARRHALIS; NEUTROPHILS; RATS; RATS, SPRAGUE-DAWLEY; STREPTOCOCCUS;

EID: 84863831095     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300356u     Document Type: Article

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