Fast Gradient HPLC Method to Determine Compounds Binding to Human Serum Albumin. Relationships with Octanol/Water and Immobilized Artificial Membrane Lipophilicity

Journal of Pharmaceutical Sciences

Volumn 92, Issue 11, 2003, Pages 2236-2248

  Valko, Klara ^a   Nunhuck, Shenaz ^a   Bevan, Chris ^a   Abraham, Michael H ^b   Reynolds, Derek P ^c  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c Reytek Ltd   (United Kingdom)

Author keywords

HPLC; HSA binding; Immobilized Artificial Membrane; Lipophilicity

Indexed keywords

ACETYLSALICYLIC ACID; ACICLOVIR; AMILORIDE; AMOXICILLIN; AMPICILLIN; AMRINONE; BECLOMETASONE; BETAMETHASONE; BROMAZEPAM; BUDESONIDE; BUMETANIDE; CARBAMAZEPINE; CEFALEXIN; CEFAZOLIN; CEFTAZIDIME; CHLORPHENIRAMINE; CHLORPROMAZINE; CHLORPROPAMIDE; DICLOFENAC; HUMAN SERUM ALBUMIN; INDOMETACIN; KETOPROFEN; NICARDIPINE; NIZATIDINE; OCTANOL; PARACETAMOL; PIROXICAM; UNINDEXED DRUG; WARFARIN; WATER;

ARTICLE; ARTIFICIAL MEMBRANE; BINDING AFFINITY; BINDING SITE; CALIBRATION; DRUG PROTEIN BINDING; DRUG SCREENING; EQUILIBRIUM CONSTANT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMOBILIZATION; IONIZATION; LIPOPHILICITY; PARTITION COEFFICIENT; PH; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SOLVATION; SURFACE CHARGE;

EID: 0242290408     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10494     Document Type: Article

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