Scalable synthesis of cortistatin A and related structures

Journal of the American Chemical Society

Volumn 133, Issue 20, 2011, Pages 8014-8027

  Shi, Jun ^a   Manolikakes, Georg ^a   Yeh, Chien Hung ^a   Guerrero, Carlos A ^a   Shenvi, Ryan A ^a   Shigehisa, Hiroki ^a   Baran, Phil S ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL STUDIES; CHEMOSELECTIVE; CORTISTATIN A; DIHALOGENATION; ETHERIFICATION REACTIONS; FUNCTIONALIZED; METHYL GROUP; RANEY NI; SCALABLE SYNTHESIS;

BIOLOGY; ETHERS; FUNCTIONAL GROUPS; OLEFINS;

SYNTHESIS (CHEMICAL);

ADAMANTANE; BROMOCYCLOPROPANE; CORTISTATIN; CORTISTATIN A; CORTISTATIN B; CORTISTATIN C; CORTISTATIN D; CORTISTATIN E; CORTISTATIN F; CORTISTATIN G; CORTISTATIN H; CORTISTATIN J; CORTISTATIN K; CORTISTATIN L; CORTISTATINONE; CYCLOPROPANE DERIVATIVE; HETEROADAMANTANE; ISOQUINOLINE DERIVATIVE; NICKEL; PREDNISONE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BIOLOGICAL ACTIVITY; CONFORMATION; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; ETHERIFICATION; FRAGMENTATION REACTION; HALOGENATION; HUMAN; HUMAN CELL; HYDRATION; MOLECULAR EVOLUTION; PEPTIDE SYNTHESIS; PROTEIN STRUCTURE; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

CELLS, CULTURED; HUMANS; POLYCYCLIC COMPOUNDS;

EID: 79957699838     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja202103e     Document Type: Article

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