Limonoid compounds inhibit sphingomyelin biosynthesis by preventing CERT protein-dependent extraction of ceramides from the endoplasmic reticulum

Journal of Biological Chemistry

Volumn 287, Issue 29, 2012, Pages 24397-24411

  Hullin Matsuda, Françoise ^a,b   Tomishige, Nario ^a   Sakai, Shota ^a   Ishitsuka, Reiko ^a   Ishii, Kumiko ^a   Makino, Asami ^a   Greimel, Peter ^a   Abe, Mitsuhiro ^a   Laviad, Elad L ^c   Lagarde, Michel ^b   Vidal, Hubert ^b   Saito, Tamio ^a   Osada, Hiroyuki ^a   Hanada, Kentaro ^d   Futerman, Anthony H ^c   Kobayashi, Toshihide ^a,b  

^a RIKEN   (Japan)

^b CarMeN   (France)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^d NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELL MEMBRANES; CERAMIDES; CHAINS; EXTRACTION; FLUORESCENCE; METABOLISM; PHOSPHOLIPIDS; PHYSIOLOGY;

ANTICANCER ACTIVITIES; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM MEMBRANES; GLYCEROPHOSPHOLIPIDS; GOLGI APPARATUS; MEMBRANE LIPIDS; MODEL MEMBRANES; NATURAL COMPOUNDS;

BIOSYNTHESIS;

3 CHLORO 8BETA HYDROXYCARAPIN 3,8 HEMIACETAL; 8BETA HYDROXYCARAPIN 3,8 HEMIACETAL; BREFELDIN A; CARRIER PROTEIN; CERAMIDE; CERAMIDE TRANSPORTER; GENUDIN; GLYCEROPHOSPHOLIPID; GLYCOLIPID; LIMONOID; LYSENIN; MEMBRANE LIPID; SPHINGOMYELIN; TOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL SURFACE; CHO CELL; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; ENDOPLASMIC RETICULUM; FEMALE; GOLGI COMPLEX; HELA CELL; IN VITRO STUDY; INHIBITION KINETICS; LIPID METABOLISM; LIPID TRANSPORT; MEMBRANE MODEL; MISCIBILITY; NONHUMAN; PHOSPHOLIPID SYNTHESIS; PHOSPHOLIPID SYNTHESIS INHIBITION; PRIORITY JOURNAL;

ANIMALS; CALORIMETRY, DIFFERENTIAL SCANNING; CERAMIDES; CHO CELLS; CRICETINAE; ENDOPLASMIC RETICULUM; HELA CELLS; HUMANS; LIMONINS; LIPID METABOLISM; MICROSCOPY, CONFOCAL; PROTEIN-SERINE-THREONINE KINASES; SPHINGOLIPIDS; SPHINGOMYELINS;

EID: 84863797860     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.344432     Document Type: Article

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