Fluorescence image screening for chemical compounds modifying cholesterol metabolism and distribution

Journal of Lipid Research

Volumn 52, Issue 11, 2011, Pages 2084-2094

  Ishitsuka, Reiko ^a   Saito, Tamio ^a   Osada, Hiroyuki ^a   Ohno Iwashita, Yoshiko ^b   Kobayashi, Toshihide ^a,c  

^a RIKEN   (Japan)

^b IWAKI MEISEI UNIVERSITY   (Japan)

^c UNIVERSITÉ LYON 1   (France)

Author keywords

toxin domain 4; Cell based screening; Cholesterol binding toxin; Cholesterol synthesis inhibitor; Filipin; Hydrophobic amines; Late endosome; Microscope based screening

Indexed keywords

2 BENZYL 1,2,3,3A,9,9A HEXAHYDROCHROMENO[2,3 C]PYRROLE; 3,5 DIHYDROXYTETRATIACONTANOIC ACID; 3,5 DIHYDROXYTETRATIACONTANOIC ACID METHYL ESTER; AMITRIPTYLINE; ANDROSTERONE; ASTEMIZOLE; BECLOMETASONE; BINDING PROTEIN; CHEMICAL COMPOUND; CHOLESTEROL BINDING PROTEIN; CINCHOCAINE; CYPROHEPTADINE; DEXAMETHASONE; FILIPIN; FLUOROMETHOLONE; FLUPHENAZINE; FOLIMYCIN; GUANABENZ ACETATE; HYCANTHONE; LOPERAMIDE; MESTRANOL; NICLOSAMIDE; OXYBUTYNIN; PENTOXYVERINE; ROTTLERIN; TAMOXIFEN; TETRACAINE; THETA TOXIN DOMAIN 4; TIOTHIXENE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CELL ASSAY; CELL MEMBRANE; CELL SURFACE; CHEMICAL ANALYSIS; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DRUG STRUCTURE; ENDOSOME; FEMALE; FLUORESCENCE IMAGE SCREENING; FLUORESCENCE MICROSCOPY; HISTOCHEMISTRY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL MEMBRANE; CHO CELLS; CHOLESTEROL; CRICETINAE; CRICETULUS; DRUG EVALUATION, PRECLINICAL; ENDOPLASMIC RETICULUM; FILIPIN; FLUORESCENT DYES; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; MICROSCOPY, FLUORESCENCE; SMALL MOLECULE LIBRARIES;

EID: 80054096601     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.D018184     Document Type: Article

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