Crystal structures of the CERT START domain with inhibitors provide insights into the mechanism of ceramide transfer

Journal of Molecular Biology

Volumn 396, Issue 2, 2010, Pages 245-251

  Kudo, Norio ^a   Kumagai, Keigo ^b   Matsubara, Ryosuke ^c   Kobayashi, Shu ^c   Hanada, Kentaro ^b   Wakatsuki, Soichi ^a   Kato, Ryuichi ^a  

^a INSTITUTE OF MATERIALS STRUCTURE SCIENCE   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Ceramide; CERT START domain; Crystal structure; Lipid transfer; Membrane interaction

Indexed keywords

AMIDE; AMINO ACID; CELL MEMBRANE PROTEIN; CERAMIDE DERIVATIVE; CERAMIDE TRANSFER PROTEIN; HYDROGEN; HYDROXYL GROUP; N (3 HYDROXY 1 HYDROXYMETHYL 3 PHENYLPROPYL)ALKANAMIDE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TRYPTOPHAN; UNCLASSIFIED DRUG; CERAMIDE; COL4A3BP PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE;

ARTICLE; CELL MEMBRANE TRANSPORT; CRYSTAL STRUCTURE; HUMAN; HYDROGEN BOND; LIPID TRANSPORT; MEMBRANE BINDING; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SURFACE PLASMON RESONANCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; CRICETULUS; DRUG ANTAGONISM; HAMSTER; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; TRANSPORT AT THE CELLULAR LEVEL; X RAY CRYSTALLOGRAPHY;

AMIDES; ANIMALS; BIOLOGICAL TRANSPORT; CERAMIDES; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

EID: 77449112767     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.12.029     Document Type: Article

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