Stereoselective synthesis and structure-activity relationship of novel ceramide trafficking inhibitors. (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide and its analogues

Journal of Medicinal Chemistry

Volumn 46, Issue 17, 2003, Pages 3688-3695

  Nakamura, Yoshitaka ^a   Matsubara, Ryosuke ^a   Kitagawa, Hidetoshi ^a   Kobayashi, Shu ^a   Kumagai, Keigo ^b   Yasuda, Satoshi ^b   Hanada, Kentaro ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; CERAMIDE; CERAMIDE DERIVATIVE; COPPER COMPLEX; DIAMINE; HPA 12; HYDROXYL GROUP; N (3 HYDROXY 1 HYDROXYMETHYL 3 PHENYLPROPYL)DODECANAMIDE; N (3 HYDROXY 1 HYDROXYMETHYL 3 PHENYLPROPYL)DODECANAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CATALYST; CHIRALITY; CHO CELL; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIASTEREOISOMER; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; IC 50; MANNICH REACTION; METHYLATION; NONHUMAN; PHOSPHOLIPID SYNTHESIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMIDES; ANIMALS; BIOLOGICAL TRANSPORT; CERAMIDES; CHO CELLS; CRICETINAE; SPHINGOMYELINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0042732934     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0300779     Document Type: Article

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