Effects on DNA integrity and apoptosis induction by a novel antitumor sesquiterpene drug, 6-hydroxymethylacylfulvene (HMAF, MGI 114)

Biochemical Pharmacology

Volumn 54, Issue 11, 1997, Pages 1181-1193

  Woynarowski, Jan M ^a,d   Napier, Cheryl ^a   Koester, Steven K ^a,e   Chen, Shih Fong ^a   Troyer, Dean ^b   Chapman, William ^a   MacDonald, John R ^c  

^a University of Texas Health Science Center at San Antonio   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c GUILFORD PHARMACEUTICALS INC   (United States)

^d CTRC Institute for Drug Development   (United States)

^e Department of Scientific Research   (United States)

Author keywords

6 hydroxymethylacylfulvene; Apoptosis; Cytotoxic activity; DNA fragmentation; S phase block

Indexed keywords

6 HYDROXYMETHYLACYLFULVENE; ANTINEOPLASTIC AGENT; DNA FRAGMENT; SESQUITERPENE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE S PHASE; CELL GROWTH; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA BINDING; DNA DETERMINATION; DNA SYNTHESIS INHIBITION; ELECTRON MICROSCOPY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; DNA; DNA DAMAGE; DNA FRAGMENTATION; FLOW CYTOMETRY; HUMANS; SESQUITERPENES;

EID: 0030718488     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00321-3     Document Type: Article

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