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Volumn , Issue , 2009, Pages 281-307

Discovery of PHA-739358

Author keywords

PHA 739358 discovery; PHA 739358 profile; Structure of Aurora A in complex with compound 21

Indexed keywords


EID: 84863768282     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470524961.ch11     Document Type: Chapter
Times cited : (3)

References (59)
  • 1
    • 17144405643 scopus 로고    scopus 로고
    • Mitotic kinesins: prospects for antimitotic drug discovery
    • Bergnes, G., Brejc, K., and Belmont, L. (2005). Mitotic kinesins: prospects for antimitotic drug discovery. Curr Top Med Chem. 5 (2), 127-145.
    • (2005) Curr Top Med Chem. , vol.5 , Issue.2 , pp. 127-145
    • Bergnes, G.1    Brejc, K.2    Belmont, L.3
  • 3
    • 0032100685 scopus 로고    scopus 로고
    • A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
    • Bischoff, J. R., Anderson, L., Zhu, Y., et al. (1998). A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J. 17 (11), 3052-3065.
    • (1998) EMBO J. , vol.17 , Issue.11 , pp. 3052-3065
    • Bischoff, J.R.1    Anderson, L.2    Zhu, Y.3
  • 4
    • 3042716081 scopus 로고    scopus 로고
    • A single amino acid exchange inverts susceptibility of related receptor tyrosine kinases for the ATP site inhibitor STI-571
    • Böhmer, F. D., Karagyozov, L., Uecker, A., et al. (2003). A single amino acid exchange inverts susceptibility of related receptor tyrosine kinases for the ATP site inhibitor STI-571. J Biol Chem. 278 (7), 5148-5155.
    • (2003) J Biol Chem. , vol.278 , Issue.7 , pp. 5148-5155
    • Böhmer, F.D.1    Karagyozov, L.2    Uecker, A.3
  • 5
    • 33847724638 scopus 로고    scopus 로고
    • Aurora-A regulation of nuclear factor-kappaB signaling by phosphorylation of IkappaBalpha
    • Briassouli, P., Chan, F., Savage, K., et al. (2007). Aurora-A regulation of nuclear factor-kappaB signaling by phosphorylation of IkappaBalpha. Cancer Res. 67 (4), 1689-1695.
    • (2007) Cancer Res. , vol.67 , Issue.4 , pp. 1689-1695
    • Briassouli, P.1    Chan, F.2    Savage, K.3
  • 6
    • 39049166077 scopus 로고    scopus 로고
    • Aurora kinase inhibitors: identification and preclinical validation of their biomarkers
    • Carpinelli, P., and Moll, J. (2008). Aurora kinase inhibitors: identification and preclinical validation of their biomarkers. Expert Opin Ther Targets. 12 (1), 69-80.
    • (2008) Expert Opin Ther Targets. , vol.12 , Issue.1 , pp. 69-80
    • Carpinelli, P.1    Moll, J.2
  • 7
    • 37549071104 scopus 로고    scopus 로고
    • PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer
    • Carpinelli, P., Ceruti, R., Giorgini, M. L., et al. (2007). PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer. Mol Cancer Ther. 6 (12 Pt 1), 3158-3168.
    • (2007) Mol Cancer Ther. , vol.6 , Issue.1-12 PT , pp. 3158-3168
    • Carpinelli, P.1    Ceruti, R.2    Giorgini, M.L.3
  • 8
    • 34247615972 scopus 로고    scopus 로고
    • Structural basis for potent inhibition of the Aurora kinases and a T315I multi-drug resistant mutant form of Abl kinase by VX-680
    • Cheetham, G. M., Charlton, P. A., Golec, J. M., et al. (2007). Structural basis for potent inhibition of the Aurora kinases and a T315I multi-drug resistant mutant form of Abl kinase by VX-680. Cancer Lett. 251 (2), 323-329.
    • (2007) Cancer Lett. , vol.251 , Issue.2 , pp. 323-329
    • Cheetham, G.M.1    Charlton, P.A.2    Golec, J.M.3
  • 9
    • 59349101062 scopus 로고    scopus 로고
    • Phase I study of the pan aurora kinases (AKs) inhibitor PHA-739358 administered as a 24 h infusion without/ with G-CSF in a 14-day cycle in patients with advanced solid tumors
    • Cohen, R. B., Jones, S. F., von Mehren, M., et al. (2008). Phase I study of the pan aurora kinases (AKs) inhibitor PHA-739358 administered as a 24 h infusion without/ with G-CSF in a 14-day cycle in patients with advanced solid tumors. J Clin Oncol. 26(Suppl), Abst 2520.
    • (2008) J Clin Oncol , vol.14 , Issue.9 , pp. 969-985
    • Cohen, R.B.1    Jones, S.F.2    Von Mehren, M.3
  • 10
    • 34247612847 scopus 로고    scopus 로고
    • Targeting cell cycle kinases for cancer therapy
    • De Carcer, G., Perez de Castro, I., and Malumbres, M. (2007). Targeting cell cycle kinases for cancer therapy. Curr Med Chem. 14 (9), 969-985.
    • (2007) Curr Med Chem. , vol.14 , Issue.9 , pp. 969-985
    • De Carcer, G.1    Perez De Castro, I.2    Malumbres, M.3
  • 11
    • 65349152111 scopus 로고    scopus 로고
    • Phase I study of the Aurora kinases (AKs) inhibitor PHA-739358 administered as a 6 and 3-h IV infusion on days 1, 8, 15 every 4 wks in patients with advanced solid tumors
    • De Jonge, M., Steeghs, N., Verweij, J., et al. (2008). Phase I study of the Aurora kinases (AKs) inhibitor PHA-739358 administered as a 6 and 3-h IV infusion on days 1, 8, 15 every 4 wks in patients with advanced solid tumors. J Clin Oncol. 26 (Suppl), Abst 3507.
    • (2008) J Clin Oncol. , vol.26 , Issue.SUPPL , pp. 3507
    • Jonge, D.M.1    Steeghs, N.2    Verweij, J.3
  • 12
    • 1542287231 scopus 로고    scopus 로고
    • Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle
    • Dewar, H., Tanaka, K., Nasmyth, K., et al. (2004). Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle. Nature. 428 (6978), 93-97.
    • (2004) Nature. , vol.428 , Issue.6978 , pp. 93-97
    • Dewar, H.1    Tanaka, K.2    Nasmyth, K.3
  • 13
    • 24944573674 scopus 로고    scopus 로고
    • Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types
    • Ewart-Toland, A., Dai, Q., Gao, Y. T., et al. (2005). Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types. Carcinogenesis. 26 (8), 1368-1373.
    • (2005) Carcinogenesis. , vol.26 , Issue.8 , pp. 1368-1373
    • Ewart-Toland, A.1    Dai, Q.2    Gao, Y.T.3
  • 15
    • 20944437351 scopus 로고    scopus 로고
    • Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition
    • Fancelli, D., Berta, D., Bindi, S., et al. (2005a). Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition. J Med Chem. 48 (8), 3080-3084.
    • (2005) J Med Chem. , vol.48 , Issue.8 , pp. 3080-3084
    • Fancelli, D.1    Berta, D.2    Bindi, S.3
  • 17
    • 33845367377 scopus 로고    scopus 로고
    • 1,4,5,6-Tetrahydropyrrolo[3,4-c ]pyrazoles:identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile
    • Fancelli, D., Moll, J., Varasi, M., et al. (2006). 1,4,5,6-Tetrahydropyrrolo[3,4-c ]pyrazoles:identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile. J Med Chem. 49 (24), 7247-7251.
    • (2006) J Med Chem. , vol.49 , Issue.24 , pp. 7247-7251
    • Fancelli, D.1    Moll, J.2    Varasi, M.3
  • 18
    • 33846988313 scopus 로고    scopus 로고
    • Roles of Aurora kinases in mitosis and tumorigenesis
    • Fu, J., Bian, M., Jiang, Q., et al. (2007). Roles of Aurora kinases in mitosis and tumorigenesis . Mol Cancer Res. 5 (1), 1-10.
    • (2007) Mol Cancer Res. , vol.5 , Issue.1 , pp. 1-10
    • Fu, J.1    Bian, M.2    Jiang, Q.3
  • 19
    • 45749115811 scopus 로고    scopus 로고
    • Midzone activation of Aurora B in anaphase produces an intracellular phosphorylation gradient
    • Fuller, B. G., Lampson, M. A., Foley, E. A., et al. (2008). Midzone activation of Aurora B in anaphase produces an intracellular phosphorylation gradient. Nature. 453 (7198), 1132-1136.
    • (2008) Nature. , vol.453 , Issue.7198 , pp. 1132-1136
    • Fuller, B.G.1    Lampson, M.A.2    Foley, E.A.3
  • 20
    • 41549122837 scopus 로고    scopus 로고
    • Aurora kinases as anticancer drug targets
    • Gautschi, O., Heighway, J., Mack, P. C., et al. (2008). Aurora kinases as anticancer drug targets. Clin Cancer Res. 14 (6), 1639-1648.
    • (2008) Clin Cancer Res. , vol.14 , Issue.6 , pp. 1639-1648
    • Gautschi, O.1    Heighway, J.2    Mack, P.C.3
  • 21
    • 33846240316 scopus 로고    scopus 로고
    • MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation
    • Giles, F. J., Cortes, J., Jones, D., et al. (2007). MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation. Blood. 109 (2), 500-502.
    • (2007) Blood. , vol.109 , Issue.2 , pp. 500-502
    • Giles, F.J.1    Cortes, J.2    Jones, D.3
  • 22
    • 0028938482 scopus 로고
    • Mutations in Aurora prevent centrosome separation leading to the formation of monopolar spindles
    • Glover, D. M., Leibowitz, M. H., McLean, D. A., et al. (1995). Mutations in Aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell. 81 (1), 95-105.
    • (1995) Cell. , vol.81 , Issue.1 , pp. 95-105
    • Glover, D.M.1    Leibowitz, M.H.2    McLean, D.A.3
  • 23
    • 43249111278 scopus 로고    scopus 로고
    • Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I
    • Gontarewicz, A., Balabanov, S., Keller, G., et al. (2008). Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I. Blood. 111 (8), 4355-4364.
    • (2008) Blood. , vol.111 , Issue.8 , pp. 4355-4364
    • Gontarewicz, A.1    Balabanov, S.2    Keller, G.3
  • 24
    • 0035962664 scopus 로고    scopus 로고
    • Histone H3 phosphorylation and cell division
    • Hans, F., and Dimitrov, S. (2001). Histone H3 phosphorylation and cell division. Oncogene. 20 (24), 3021-3027.
    • (2001) Oncogene. , vol.20 , Issue.24 , pp. 3021-3027
    • Hans, F.1    Dimitrov, S.2
  • 25
    • 2342639645 scopus 로고    scopus 로고
    • VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
    • Harrington, E. A., Bebbington, D., Moore, J., et al. (2004). VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat Med. 10 (3), 262-267.
    • (2004) Nat Med. , vol.10 , Issue.3 , pp. 262-267
    • Harrington, E.A.1    Bebbington, D.2    Moore, J.3
  • 26
    • 0141429171 scopus 로고    scopus 로고
    • Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells
    • Hirota, T., Kunitoku, N., Sasayama, T., et al. (2003). Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell. 114 (5), 585-598.
    • (2003) Cell. , vol.114 , Issue.5 , pp. 585-598
    • Hirota, T.1    Kunitoku, N.2    Sasayama, T.3
  • 28
    • 0036045353 scopus 로고    scopus 로고
    • Fibroblast growth factors in cancer: therapeutic possibilities
    • Jeffers, M., LaRochelle, W. J., and Lichenstein, H. S. (2002). Fibroblast growth factors in cancer: therapeutic possibilities. Expert Opin Ther Targets. 6 (4), 469-482.
    • (2002) Expert Opin Ther Targets. , vol.6 , Issue.4 , pp. 469-482
    • Jeffers, M.1    LaRochelle, W.J.2    Lichenstein, H.S.3
  • 29
    • 0036083301 scopus 로고    scopus 로고
    • Mechanism of action of antitumor drugs that interact with microtubules and tubulin
    • Jordan, M. A. (2002). Mechanism of action of antitumor drugs that interact with microtubules and tubulin. Curr Med Chem Anticancer Agents. 2 (1), 1-17.
    • (2002) Curr Med Chem Anticancer Agents. , vol.2 , Issue.1 , pp. 1-17
    • Jordan, M.A.1
  • 30
    • 1942438028 scopus 로고    scopus 로고
    • Microtubules as a target for anticancer drugs
    • Jordan, M. A., and Wilson, L. (2004). Microtubules as a target for anticancer drugs. Nat Rev Cancer. 4 (4), 253-265.
    • (2004) Nat Rev Cancer. , vol.4 , Issue.4 , pp. 253-265
    • Jordan, M.A.1    Wilson, L.2
  • 31
    • 0038341158 scopus 로고    scopus 로고
    • The Aurora kinases: role in cell transformation and tumorigenesis
    • Katayama, H., Brinkley, W. R., and Sen, S. (2003). The Aurora kinases: role in cell transformation and tumorigenesis. Cancer Metastasis Rev. 22 (4), 451-464.
    • (2003) Cancer Metastasis Rev. , vol.22 , Issue.4 , pp. 451-464
    • Katayama, H.1    Brinkley, W.R.2    Sen, S.3
  • 32
    • 9144251019 scopus 로고    scopus 로고
    • Phosphorylation by Aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53
    • Katayama, H., Sasai, K., Kawai, H., et al. (2004). Phosphorylation by Aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat Genet. 36 (1), 55-62.
    • (2004) Nat Genet. , vol.36 , Issue.1 , pp. 55-62
    • Katayama, H.1    Sasai, K.2    Kawai, H.3
  • 33
    • 0141768273 scopus 로고    scopus 로고
    • Function and regulation of Aurora/Ipl1p kinase family in cell division
    • Ke, Y. W., Dou, Z., Zhang, J., and Yao, X. B. (2003). Function and regulation of Aurora/Ipl1p kinase family in cell division. Cell Res. 13 (2), 69-81.
    • (2003) Cell Res. , vol.13 , Issue.2 , pp. 69-81
    • Ke, Y.W.1    Dou, Z.2    Zhang, J.3    Yao, X.B.4
  • 34
    • 13844317894 scopus 로고    scopus 로고
    • EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
    • Kobayashi, S., Boggon, T. J., Dayaram, T., et al. (2005). EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med. 352 (8), 786-792.
    • (2005) N Engl J Med. , vol.352 , Issue.8 , pp. 786-792
    • Kobayashi, S.1    Boggon, T.J.2    Dayaram, T.3
  • 35
    • 17744373695 scopus 로고    scopus 로고
    • The RET proto-oncogene: a molecular therapeutic target in thyroid cancer
    • Kodama, Y., Asai, N., Kawai, K., et al. (2005). The RET proto-oncogene: a molecular therapeutic target in thyroid cancer. Cancer Sci. 96 (3), 143-148.
    • (2005) Cancer Sci. , vol.96 , Issue.3 , pp. 143-148
    • Kodama, Y.1    Asai, N.2    Kawai, K.3
  • 36
    • 0037135979 scopus 로고    scopus 로고
    • Human TPX2 is required for targeting Aurora-A kinase to the spindle
    • Kufer, T. A., Sillje, H. H., Korner, R., et al. (2002). Human TPX2 is required for targeting Aurora-A kinase to the spindle. J Cell Biol. 158 (4), 617-623.
    • (2002) J Cell Biol. , vol.158 , Issue.4 , pp. 617-623
    • Kufer, T.A.1    Sillje, H.H.2    Korner, R.3
  • 37
    • 10644227569 scopus 로고    scopus 로고
    • Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215
    • Liu, Q., Kaneko, S., Yang, L., et al. (2004). Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215. J Biol Chem. 279 (50), 52175-52182.
    • (2004) J Biol Chem. , vol.279 , Issue.50 , pp. 52175-52182
    • Liu, Q.1    Kaneko, S.2    Yang, L.3
  • 38
    • 34247259822 scopus 로고    scopus 로고
    • Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase
    • Manfredi, M. G., Ecsedy, J. A., Meetze, K. A., et al. (2007). Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase. Proc Natl Acad Sci USA. 104 (10), 4106-4111.
    • (2007) Proc Natl Acad Sci USA. , vol.104 , Issue.10 , pp. 4106-4111
    • Manfredi, M.G.1    Ecsedy, J.A.2    Meetze, K.A.3
  • 39
    • 34548548332 scopus 로고    scopus 로고
    • Crystal structure of the T315I Abl mutant in complex with the Aurora kinases inhibitor PHA-739358
    • Modugno, M., Casale, E., Soncini, C., et al. (2007). Crystal structure of the T315I Abl mutant in complex with the Aurora kinases inhibitor PHA-739358. Cancer Res. 67 (17), 7987-7990.
    • (2007) Cancer Res. , vol.67 , Issue.17 , pp. 7987-7990
    • Modugno, M.1    Casale, E.2    Soncini, C.3
  • 40
    • 34347405054 scopus 로고    scopus 로고
    • Maximal chromosome compaction occurs by axial shortening in anaphase and depends on Aurora kinase
    • Mora-Bermúdez, F., Gerlich, D., and Ellenberg, J. (2007). Maximal chromosome compaction occurs by axial shortening in anaphase and depends on Aurora kinase. Nat Cell Biol. 9 (7), 822-831.
    • (2007) Nat Cell Biol. , vol.9 , Issue.7 , pp. 822-831
    • Mora-Bermúdez, F.1    Gerlich, D.2    Ellenberg, J.3
  • 41
    • 0037018843 scopus 로고    scopus 로고
    • The kinase activity of Aurora B is required for kinetochore-microtubule interactions during mitosis
    • Murata-Hori, M., and Wang, Y. L. (2002). The kinase activity of Aurora B is required for kinetochore-microtubule interactions during mitosis. Curr Biol. 12 (11), 894-899.
    • (2002) Curr Biol. , vol.12 , Issue.11 , pp. 894-899
    • Murata-Hori, M.1    Wang, Y.L.2
  • 42
    • 0038156100 scopus 로고    scopus 로고
    • Mutation, SNP, and isoform analysis of fibroblast growth factor receptor 3 (FGFR3) in 150 newly diagnosed multiple myeloma patients
    • Onwuazor, O. N., Wen, X. Y., Wang, D. Y., et al. (2003). Mutation, SNP, and isoform analysis of fibroblast growth factor receptor 3 (FGFR3) in 150 newly diagnosed multiple myeloma patients. Blood. 102 (2), 772-773.
    • (2003) Blood. , vol.102 , Issue.2 , pp. 772-773
    • Onwuazor, O.N.1    Wen, X.Y.2    Wang, D.Y.3
  • 43
    • 2942522534 scopus 로고    scopus 로고
    • 3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents
    • Pevarello, P., Brasca, M. G., Amici, R., et al. (2004). 3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding. J Med Chem. 47 (13), 3367-3380.
    • (2004) 1. Lead finding. J Med Chem. , vol.47 , Issue.13 , pp. 3367-3380
    • Pevarello, P.1    Brasca, M.G.2    Amici, R.3
  • 44
    • 33645220356 scopus 로고    scopus 로고
    • HEF1-Aurora A interactions: points of dialog between the cell cycle and cell attachment signaling networks
    • Pugacheva, E. N., and Golemis, E. A. (2006). HEF1-Aurora A interactions: points of dialog between the cell cycle and cell attachment signaling networks. Cell Cycle. 5 (4), 384-391.
    • (2006) Cell Cycle. , vol.5 , Issue.4 , pp. 384-391
    • Pugacheva, E.N.1    Golemis, E.A.2
  • 45
    • 21644465065 scopus 로고    scopus 로고
    • Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1
    • Sasayama, T., Marumoto, T., Kunitoku, N., et al. (2005). Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1. Genes Cells. 10 (7), 627-638.
    • (2005) Genes Cells. , vol.10 , Issue.7 , pp. 627-638
    • Sasayama, T.1    Marumoto, T.2    Kunitoku, N.3
  • 46
    • 39049126024 scopus 로고    scopus 로고
    • Inhibitors of cyclin dependent kinases:useful targets for cancer treatment
    • Sharma, P. S., Sharma, R., and Tyagi, R. (2008). Inhibitors of cyclin dependent kinases:useful targets for cancer treatment. Curr Cancer Drug Targets. 8 (1), 53-75.
    • (2008) Curr Cancer Drug Targets. , vol.8 , Issue.1 , pp. 53-75
    • Sharma, P.S.1    Sharma, R.2    Tyagi, R.3
  • 47
    • 0842282616 scopus 로고    scopus 로고
    • Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth kinetics in xenograft models after administration of anticancer agents
    • Simeoni, M., Magni, P., Cammia, C., et al. (2004). Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth kinetics in xenograft models after administration of anticancer agents. Cancer Res. 64 (3), 1094-1101.
    • (2004) Cancer Res. , vol.64 , Issue.3 , pp. 1094-1101
    • Simeoni, M.1    Magni, P.2    Cammia, C.3
  • 48
    • 33746080016 scopus 로고    scopus 로고
    • PHA-680632, a novel Aurora kinase inhibitor with potent antitumoral activity
    • Soncini, C., Carpinelli, P., Gianellini, L., et al. (2006). PHA-680632, a novel Aurora kinase inhibitor with potent antitumoral activity. Clin Cancer Res. 12 (13), 4080-4089.
    • (2006) Clin Cancer Res. , vol.12 , Issue.13 , pp. 4080-4089
    • Soncini, C.1    Carpinelli, P.2    Gianellini, L.3
  • 49
    • 34548217817 scopus 로고    scopus 로고
    • Aurora-C-T191D is a hyperactive Aurora-C mutant
    • Spengler, D. (2007). Aurora-C-T191D is a hyperactive Aurora-C mutant. Cell Cycle. 6 (14), 1803-1804.
    • (2007) Cell Cycle. , vol.6 , Issue.14 , pp. 1803-1804
    • Spengler, D.1
  • 50
    • 33749824425 scopus 로고    scopus 로고
    • Functional analyses and molecular modeling of two c-Kit mutations responsible for imatinib secondary resistance in GIST patients
    • Tamborini, E., Pricl, S., Negri, T., et al. (2006). Functional analyses and molecular modeling of two c-Kit mutations responsible for imatinib secondary resistance in GIST patients. Oncogene. 25 (45), 6140-6146.
    • (2006) Oncogene. , vol.25 , Issue.45 , pp. 6140-6146
    • Tamborini, E.1    Pricl, S.2    Negri, T.3
  • 51
    • 34548407864 scopus 로고    scopus 로고
    • FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer
    • Tomlinson, D. C., Baldo, O., Harnden, P., et al. (2007). FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer. J Pathol. 213 (1), 91-98.
    • (2007) J Pathol. , vol.213 , Issue.1 , pp. 91-98
    • Tomlinson, D.C.1    Baldo, O.2    Harnden, P.3
  • 56
    • 5044236233 scopus 로고    scopus 로고
    • Sequence and structural analysis of kinase ATP pocket residues
    • Vulpetti, A., and Bosotti, R. (2004). Sequence and structural analysis of kinase ATP pocket residues. Farmaco. 59 (10), 759-765.
    • (2004) Farmaco. , vol.59 , Issue.10 , pp. 759-765
    • Vulpetti, A.1    Bosotti, R.2
  • 57
    • 34250739960 scopus 로고    scopus 로고
    • AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis
    • Wilkinson, R. W., Odedra, R., Heaton, S. P., et al. (2007). AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis . Clin Cancer Res. 13 (12), 3682-3688.
    • (2007) Clin Cancer Res. , vol.13 , Issue.12 , pp. 3682-3688
    • Wilkinson, R.W.1    Odedra, R.2    Heaton, S.P.3
  • 58
    • 20444426846 scopus 로고    scopus 로고
    • Mitotic requirement for Aurora A kinase is bypassed in the absence of Aurora B kinase
    • Yang, H., Burke, T., Dempsey, J., et al. (2005). Mitotic requirement for Aurora A kinase is bypassed in the absence of Aurora B kinase. FEBS Lett. 579 (16), 3385-3391.
    • (2005) FEBS Lett. , vol.579 , Issue.16 , pp. 3385-3391
    • Yang, H.1    Burke, T.2    Dempsey, J.3
  • 59
    • 0031714080 scopus 로고    scopus 로고
    • Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
    • Zhou, H., Kuang, J., Zhong, L., et al. (1998). Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet. 20 (2), 189-193
    • (1998) Nat Genet. , vol.20 , Issue.2 , pp. 189-193
    • Zhou, H.1    Kuang, J.2    Zhong, L.3


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