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Volumn 19, Issue 21, 2012, Pages 3523-3531

Trigonelline: A plant alkaloid with therapeutic potential for diabetes and central nervous system disease

Author keywords

Alkaloid; Anti tumor; Antibacterial; Antihyperlipidemia; Central nervous system disease; Diabetes; Diabetic complications; Hypoglycemia; Neuroprotective; Pharmacokinetics; Toxicology; Trigonella foenum graecum L; Trigonelline

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; AMYLOID BETA PROTEIN; ANTIHISTAMINIC AGENT; ANTIMIGRAINE AGENT; ANTIPARASITIC AGENT; CHOLINESTERASE INHIBITOR; INCRETIN; TRIGONELLINE;

EID: 84863746781     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712801323171     Document Type: Review
Times cited : (320)

References (67)
  • 1
    • 0035070501 scopus 로고    scopus 로고
    • Evaluation of the oral hypoglycaemic effect of Trigonella foenum-graecum L. (methi) in normal mice
    • Zia, T.; Hasnain, S.N.; Hasan, S.K. Evaluation of the oral hypoglycaemic effect of Trigonella foenum-graecum L. (methi) in normal mice. J. Ethnopharmacol. 2001, 75 (2-3), 191-195.
    • (2001) J. Ethnopharmacol , vol.75 , Issue.2-3 , pp. 191-195
    • Zia, T.1    Hasnain, S.N.2    Hasan, S.K.3
  • 2
    • 3343015265 scopus 로고    scopus 로고
    • Handbook of medicinal plants-A complete source book
    • Prajapati; Purohit; Sharma; Kumar A Handbook of Medicinal Plants-A Complete Source Book. In Agrobios; 2003; pp. 523.
    • (2003) Agrobios , pp. 523
    • Prajapati, P.1    Sharma Kumar, A.2
  • 3
    • 84863740940 scopus 로고    scopus 로고
    • State Administration of Traditional Chinese Medicine Chinese Materia Medica (IV). In Shanghai Science and Technology Press: Shanghai
    • State Administration of Traditional Chinese Medicine "Chinese Materia Medica" Editorial Board. Chinese Materia Medica (IV). In Shanghai Science and Technology Press: Shanghai, 1999; pp. 674.
    • (1999) "chinese Materia Medica" Editorial Board , pp. 674
  • 4
    • 0023025947 scopus 로고
    • Effect of fenugreek seeds and leaves on blood glucose and serum insulin responses in human subjects
    • Sharma, R. Effect of fenugreek seeds and leaves on blood glucose and serum insulin responses in human subjects. Nutr. Res. 1986, 6 (12), 1353-1364.
    • (1986) Nutr. Res. , vol.6 , Issue.12 , pp. 1353-1364
    • Sharma, R.1
  • 5
    • 34248216793 scopus 로고    scopus 로고
    • Fenugreek: The genus Trigonella
    • Petropoulos, G.A. Fenugreek: the genus Trigonella; CRC: 2002; Vol. 11, pp. 1-201.
    • (2002) CRC , vol.11 , pp. 1-201
    • Petropoulos, G.A.1
  • 6
    • 0025108079 scopus 로고
    • Hypoglycaemic effect of fenugreek seeds in non-insulin dependent diabetic subjects
    • Sharma, R.; Raghuram, T. Hypoglycaemic effect of fenugreek seeds in non-insulin dependent diabetic subjects. Nutr. Res. 1990, 10 (7), 731-739.
    • (1990) Nutr. Res. , vol.10 , Issue.7 , pp. 731-739
    • Sharma, R.1    Raghuram, T.2
  • 7
    • 0023695959 scopus 로고
    • Effect of fenugreek and lupine seeds on the development of experimental diabetes in rats
    • Riyad, M.A.; Abdul-Salam, S.A.; Mohammad, S.S. Effect of fenugreek and lupine seeds on the development of experimental diabetes in rats. Planta Med. 1988, 54 (4), 286-290.
    • (1988) Planta Med. , vol.54 , Issue.4 , pp. 286-290
    • Riyad, M.A.1    Abdul-Salam, S.A.2    Mohammad, S.S.3
  • 9
    • 73649166036 scopus 로고
    • Nutritive value of some leaf-proteins. I. Amino-acid composition of Trigonella foenum-graecum and Hibiscus cannabinus
    • Talwalkar, R.T.; Patel, S.M. Nutritive value of some leaf-proteins. I. Amino-acid composition of Trigonella foenum-graecum and Hibiscus cannabinus. Ann. Biochem. Exp. Med. 1962, 22, 289-294.
    • (1962) Ann. Biochem. Exp. Med. , Issue.22 , pp. 289-294
    • Talwalkar, R.T.1    Patel, S.M.2
  • 10
    • 78651159525 scopus 로고
    • A phytochemical investigation of Trigonella Corniculata Linn
    • Atal, C.K.; Sood, S.P. A phytochemical investigation of Trigonella Corniculata Linn. J. Pharm. Pharmacol. 1964, 16, 627-629.
    • (1964) J. Pharm. Pharmacol. , vol.16 , pp. 627-629
    • Atal, C.K.1    Sood, S.P.2
  • 11
    • 70349308395 scopus 로고    scopus 로고
    • Trigonelline is a novel phytoestrogen in coffee beans
    • Allred, K.F.; Yackley, K.M.; Vanamala, J.; Allred, C.D. Trigonelline is a novel phytoestrogen in coffee beans. J. Nutr. 2009, 139 (10), 1833-1838.
    • (2009) J. Nutr. , vol.139 , Issue.10 , pp. 1833-1838
    • Allred, K.F.1    Yackley, K.M.2    Vanamala, J.3    Allred, C.D.4
  • 13
    • 67049159773 scopus 로고    scopus 로고
    • Anti-diabetic effects of pumpkin and its components, trigonelline and nicotinic acid, on Goto-Kakizaki rats
    • Yoshinari, O.; Sato, H.; Igarashi, K. Anti-diabetic effects of pumpkin and its components, trigonelline and nicotinic acid, on Goto-Kakizaki rats. Biosci. Biotechnol. Biochem. 2009, 73 (5), 1033-1041.
    • (2009) Biosci. Biotechnol. Biochem. , vol.73 , Issue.5 , pp. 1033-1041
    • Yoshinari, O.1    Sato, H.2    Igarashi, K.3
  • 14
    • 20944450901 scopus 로고    scopus 로고
    • Search for natural products related to regeneration of the neuronal network
    • Tohda, C.; Kuboyama, T.; Komatsu, K. Search for natural products related to regeneration of the neuronal network. Neurosignals 2005, 14 (1-2), 34-45.
    • (2005) Neurosignals , vol.14 , Issue.1-2 , pp. 34-45
    • Tohda, C.1    Kuboyama, T.2    Komatsu, K.3
  • 15
    • 79953102034 scopus 로고    scopus 로고
    • Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids
    • Ozcelik, B.; Kartal, M.; Orhan, I. Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids. Pharm. Biol. 2011, 49 (4), 396-402.
    • (2011) Pharm. Biol. , vol.49 , Issue.4 , pp. 396-402
    • Ozcelik, B.1    Kartal, M.2    Orhan, I.3
  • 16
    • 47249139019 scopus 로고    scopus 로고
    • Coffee improves auditory neuropathy in diabetic mice
    • Hong, B.N.; Yi, T.H.; Park, R.; Kim, S.Y.; Kang, T.H. Coffee improves auditory neuropathy in diabetic mice. Neurosci. Lett. 2008, 441 (3), 302-306.
    • (2008) Neurosci. Lett. , vol.441 , Issue.3 , pp. 302-306
    • Hong, B.N.1    Yi, T.H.2    Park, R.3    Kim, S.Y.4    Kang, T.H.5
  • 17
    • 65249149637 scopus 로고    scopus 로고
    • High-dosage pyridoxine-induced auditory neuropathy and protection with coffee in mice
    • Hong, B.N.; Yi, T.H.; Kim, S.Y.; Kang, T.H. High-dosage pyridoxine-induced auditory neuropathy and protection with coffee in mice. Biol. Pharm. Bull. 2009, 32 (4), 597-603.
    • (2009) Biol. Pharm. Bull. , vol.32 , Issue.4 , pp. 597-603
    • Hong, B.N.1    Yi, T.H.2    Kim, S.Y.3    Kang, T.H.4
  • 18
    • 17844385608 scopus 로고    scopus 로고
    • Anti-invasive activity of niacin and trigonelline against cancer cells
    • Hirakawa, N.; Okauchi, R.; Miura, Y.; Yagasaki, K. Anti-invasive activity of niacin and trigonelline against cancer cells. Biosci. Biotechnol. Biochem. 2005, 69 (3), 653-658.
    • (2005) Biosci. Biotechnol. Biochem. , vol.69 , Issue.3 , pp. 653-658
    • Hirakawa, N.1    Okauchi, R.2    Miura, Y.3    Yagasaki, K.4
  • 19
    • 22644447054 scopus 로고
    • Biosynthesis of trigonelline
    • Joshi, J.G.; Handler, P. Biosynthesis of trigonelline. J. Biol. Chem. 1960, 235, 2981-2983.
    • (1960) J. Biol. Chem. , vol.235 , pp. 2981-2983
    • Joshi, J.G.1    Handler, P.2
  • 20
    • 0025364724 scopus 로고
    • Proton release from flavoprotein D-amino acid oxidase on complexation with the zwitterionic ligand, trigonelline
    • Nishina, Y.; Sato, K.; Shiga, K. Proton release from flavoprotein D-amino acid oxidase on complexation with the zwitterionic ligand, trigonelline. J. Biochem. 1990, 107 (5), 726-731.
    • (1990) J. Biochem. , vol.107 , Issue.5 , pp. 726-731
    • Nishina, Y.1    Sato, K.2    Shiga, K.3
  • 21
    • 77953391731 scopus 로고    scopus 로고
    • Pharmacological actions and potential uses of Trigonella foenum-graecum: A review
    • Toppo, F.A.; Akhand, R.; Pathak, A. Pharmacological actions and potential uses of Trigonella foenum-graecum: A review. Asian J. Pharm. Clin. Res. 2009, 2 (4), 28-38.
    • (2009) Asian J. Pharm. Clin. Res. , vol.2 , Issue.4 , pp. 28-38
    • Toppo, F.A.1    Akhand, R.2    Pathak, A.3
  • 22
    • 79960638172 scopus 로고    scopus 로고
    • A review on biology, cultivation and biotechnology of fenugreek (Trigonella foenum-graecum L) as a valuable medicinal plant and multipurpose
    • Mehrafarin, A.; Rezazadeh, S.; Naghdi Badi, H.; Noormohammadi, G.; Zand, E.; Qaderi, A. A review on biology, cultivation and biotechnology of fenugreek (Trigonella foenum-graecum L.) as a valuable medicinal plant and multipurpose. J. Med. Plants 2011, 10 (37), 6-24.
    • (2011) J. Med. Plants , vol.10 , Issue.37 , pp. 6-24
    • Mehrafarin, A.1    Rezazadeh, S.2    Naghdi Badi, H.3    Noormohammadi, G.4    Zand, E.5    Qaderi, A.6
  • 23
    • 33646456195 scopus 로고    scopus 로고
    • Fenugreek (Trigonella foenum-graecum): A review of health beneficial physiological effects
    • Srinivasan, K. Fenugreek (Trigonella foenum-graecum): A review of health beneficial physiological effects. Food Rev. Int. 2006, 22 (2), 203-224.
    • (2006) Food Rev. Int. , vol.22 , Issue.2 , pp. 203-224
    • Srinivasan, K.1
  • 25
    • 56249127562 scopus 로고    scopus 로고
    • Trigonelline (N-methylnicotinic acid) biosynthesis and its biological role in plants
    • Ashihara, H. Trigonelline (N-methylnicotinic acid) biosynthesis and its biological role in plants. Nat. Prod. Commun. 2008, 3 (9), 1423-1428.
    • (2008) Nat. Prod. Commun. , vol.3 , Issue.9 , pp. 1423-1428
    • Ashihara, H.1
  • 26
    • 84877801646 scopus 로고    scopus 로고
    • Experimental diabetes treated with trigonelline: Effect on beta cell and pancreatic oxidative parameters
    • doi: 10.1111/j.1472-8206.2011.01022.x
    • Zhou, J.; Zhou, S.; Zeng, S. Experimental diabetes treated with trigonelline: effect on beta cell and pancreatic oxidative parameters. Fundam. Clin. Pharmacol. 2011, doi: 10.1111/j.1472-8206.2011.01022.x.
    • (2011) Fundam. Clin. Pharmacol.
    • Zhou, J.1    Zhou, S.2    Zeng, S.3
  • 27
    • 0016264635 scopus 로고
    • Hypoglycaemic effect of Trigonella foenum graecum and Lupinus termis (leguminosae) seeds and their major alkaloids in alloxan-diabetic and normal rats
    • Mishkinsky, J.S.; Goldschmied, A.; Joseph, B.; Ahronson, Z.; Sulman, F.G. Hypoglycaemic effect of Trigonella foenum graecum and Lupinus termis (leguminosae) seeds and their major alkaloids in alloxan-diabetic and normal rats. Arch. Int. Pharmacodyn. Ther. 1974, 210 (1), 27-37.
    • (1974) Arch. Int. Pharmacodyn. Ther. , vol.210 , Issue.1 , pp. 27-37
    • Mishkinsky, J.S.1    Goldschmied, A.2    Joseph, B.3    Ahronson, Z.4    Sulman, F.G.5
  • 28
    • 0014208934 scopus 로고
    • Hypoglycaemic effect of trigonelline
    • Mishkinsky, J.; Joseph, B.; Sulman, F.G. Hypoglycaemic effect of trigonelline. Lancet 1967, 2 (7529), 1311-1312.
    • (1967) Lancet , vol.2 , Issue.7529 , pp. 1311-1312
    • Mishkinsky, J.1    Joseph, B.2    Sulman, F.G.3
  • 29
    • 0034767317 scopus 로고    scopus 로고
    • Vitro effect of fenugreek extracts on intestinal sodium-dependent glucose uptake and hepatic glycogen phosphorylase A
    • Al-Habori, M.; Raman, A.; Lawrence, M.J.; Skett, P. In vitro effect of fenugreek extracts on intestinal sodium-dependent glucose uptake and hepatic glycogen phosphorylase A. Int. J. Exp. Diabetes Res. 2001, 2 (2), 91-99.
    • (2001) Int. J. Exp. Diabetes Res. , vol.2 , Issue.2 , pp. 91-99
    • Al-Habori, M.1    Raman, A.2    Lawrence, M.J.3    Skett, P.4
  • 30
    • 66549126196 scopus 로고    scopus 로고
    • Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance
    • van Dijk, A.E.; Olthof, M.R.; Meeuse, J.C.; Seebus, E.; Heine, R.J.; van Dam, R.M. Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance. Diabetes Care 2009, 32 (6), 1023-1025.
    • (2009) Diabetes Care , vol.32 , Issue.6 , pp. 1023-1025
    • Van Dijk, A.E.1    Olthof, M.R.2    Meeuse, J.C.3    Seebus, E.4    Heine, R.J.5    Van Dam, R.M.6
  • 31
    • 79551642386 scopus 로고    scopus 로고
    • Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on incretin hormones
    • Olthof, M.R.; van Dijk, A.E.; Deacon, C.F.; Heine, R.J.; van Dam, R.M. Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on incretin hormones. Nutr. Metab. (Lond) 2011, 8, 10.
    • (2011) Nutr. Metab. (Lond) , vol.8 , pp. 10
    • Olthof, M.R.1    Van Dijk, A.E.2    Deacon, C.F.3    Heine, R.J.4    Van Dam, R.M.5
  • 32
    • 79958099469 scopus 로고
    • Effect of betaines and taurine and its derivatives on plasma cholesterol levels in rats
    • Abe, S.; Kaneda, T. Effect of betaines and taurine and its derivatives on plasma cholesterol levels in rats. Eiyo To Shokuryo 1975, 28 (3), 125-128.
    • (1975) Eiyo to Shokuryo , vol.28 , Issue.3 , pp. 125-128
    • Abe, S.1    Kaneda, T.2
  • 33
  • 34
    • 16344386399 scopus 로고    scopus 로고
    • Antioxidant properties of roasted coffee residues
    • Yen, W.J.; Wang, B.S.; Chang, L.W.; Duh, P.D. Antioxidant properties of roasted coffee residues. J. Agric. Food Chem. 2005, 53 (7), 2658-2663.
    • (2005) J. Agric. Food Chem. , vol.53 , Issue.7 , pp. 2658-2663
    • Yen, W.J.1    Wang, B.S.2    Chang, L.W.3    Duh, P.D.4
  • 36
    • 0016195579 scopus 로고
    • Biopharmacological effects of coffee substances other than caffeine
    • Czok, G. Biopharmacological effects of coffee substances other than caffeine. Arch. Sci. Med. (Torino) 1974, 131 (1), 15-17.
    • (1974) Arch. Sci. Med. (Torino) , vol.131 , Issue.1 , pp. 15-17
    • Czok, G.1
  • 39
    • 0032779216 scopus 로고    scopus 로고
    • Trigonelline-induced neurite outgrowth in human neuroblastoma SK-N-SH cells
    • Tohda, C.; Nakamura, N.; Komatsu, K.; Hattori, M. Trigonelline-induced neurite outgrowth in human neuroblastoma SK-N-SH cells. Biol. Pharm. Bull. 1999, 22 (7), 679-682.
    • (1999) Biol. Pharm. Bull. , vol.22 , Issue.7 , pp. 679-682
    • Tohda, C.1    Nakamura, N.2    Komatsu, K.3    Hattori, M.4
  • 40
    • 33747202181 scopus 로고    scopus 로고
    • A pyridinium derivative from Red Sea soft corals inhibited voltage-activated potassium conductances and increased excitability of rat cultured sensory neurones
    • Temraz, T.A.; Houssen, W.E.; Jaspars, M.; Woolley, D.R.; Wease, K.N.; Davies, S.N.; Scott, R.H. A pyridinium derivative from Red Sea soft corals inhibited voltage-activated potassium conductances and increased excitability of rat cultured sensory neurones. BMC Pharmacol. 2006, 6, 10.
    • (2006) BMC Pharmacol. , vol.6 , pp. 10
    • Temraz, T.A.1    Houssen, W.E.2    Jaspars, M.3    Woolley, D.R.4    Wease, K.N.5    Davies, S.N.6    Scott, R.H.7
  • 42
    • 75249098801 scopus 로고    scopus 로고
    • Acetylcholinesterase enzyme inhibitory potential of standardized extract of Trigonella foenum graecum L and its constituents
    • Satheeshkumar, N.; Mukherjee, P.K.; Bhadra, S.; Saha, B.P. Acetylcholinesterase enzyme inhibitory potential of standardized extract of Trigonella foenum graecum L and its constituents. Phytomedicine 2010, 17 (3-4), 292-295.
    • (2010) Phytomedicine , vol.17 , Issue.3-4 , pp. 292-295
    • Satheeshkumar, N.1    Mukherjee, P.K.2    Bhadra, S.3    Saha, B.P.4
  • 44
    • 84855267433 scopus 로고    scopus 로고
    • Identification of coffee components that stimulate dopamine release from pheochromocytoma cells (PC-12)
    • Walker, J.; Rohm, B.; Lang, R.; Pariza, M.W.; Hofmann, T.; Somoza, V. Identification of coffee components that stimulate dopamine release from pheochromocytoma cells (PC-12). Food Chem. Toxicol. 2012, 50 (2), 390-398.
    • (2012) Food Chem. Toxicol. , vol.50 , Issue.2 , pp. 390-398
    • Walker, J.1    Rohm, B.2    Lang, R.3    Pariza, M.W.4    Hofmann, T.5    Somoza, V.6
  • 45
    • 79953854349 scopus 로고    scopus 로고
    • Surface plasmon resonance based biosensors for exploring the influence of alkaloids on aggregation of amyloid-beta peptide
    • Krazinski, B.E.; Radecki, J.; Radecka, H. Surface plasmon resonance based biosensors for exploring the influence of alkaloids on aggregation of amyloid-beta peptide. Sensors (Basel) 2011, 11 (4), 4030-4042.
    • (2011) Sensors (Basel) , vol.11 , Issue.4 , pp. 4030-4042
    • Krazinski, B.E.1    Radecki, J.2    Radecka, H.3
  • 46
    • 0038324270 scopus 로고    scopus 로고
    • Assessment of antimicrobial activity of hydrophilic betaines in osmotically stressed bacteria
    • Peddie, B.A.; Wood, J.E.; Lever, M.; Happer, D.A.; de Zwart, F.; Chambers, S.T. Assessment of antimicrobial activity of hydrophilic betaines in osmotically stressed bacteria. Antonie Van Leeuwenhoek 2003, 83 (2), 175-181.
    • (2003) Antonie Van Leeuwenhoek , vol.83 , Issue.2 , pp. 175-181
    • Peddie, B.A.1    Wood, J.E.2    Lever, M.3    Happer, D.A.4    De Zwart, F.5    Chambers, S.T.6
  • 48
    • 0032032163 scopus 로고    scopus 로고
    • Osmoprotective properties and accumulation of betaine analogues by Staphylococcus aureus
    • Peddie, B.A.; Wong-She, J.; Randall, K.; Lever, M.; Chambers, S.T. Osmoprotective properties and accumulation of betaine analogues by Staphylococcus aureus. FEMS Microbiol. Lett. 1998, 160 (1), 25-30.
    • (1998) FEMS Microbiol. Lett. , vol.160 , Issue.1 , pp. 25-30
    • Peddie, B.A.1    Wong-She, J.2    Randall, K.3    Lever, M.4    Chambers, S.T.5
  • 49
    • 0037180990 scopus 로고    scopus 로고
    • Antiadhesive effect of green and roasted coffee on Streptococcus mutans' adhesive properties on saliva-coated hydroxyapatite beads
    • Daglia, M.; Tarsi, R.; Papetti, A.; Grisoli, P.; Dacarro, C.; Pruzzo, C.; Gazzani, G. Antiadhesive effect of green and roasted coffee on Streptococcus mutans' adhesive properties on saliva-coated hydroxyapatite beads. J. Agric. Food Chem. 2002, 50 (5), 1225-1229.
    • (2002) J. Agric. Food Chem. , vol.50 , Issue.5 , pp. 1225-1229
    • Daglia, M.1    Tarsi, R.2    Papetti, A.3    Grisoli, P.4    Dacarro, C.5    Pruzzo, C.6    Gazzani, G.7
  • 50
    • 33751303989 scopus 로고    scopus 로고
    • Antibacterial activity of coffee extracts and selected coffee chemical compounds against enterobacteria
    • Almeida, A.A.; Farah, A.; Silva, D.A.; Nunan, E.A.; Gloria, M.B. Antibacterial activity of coffee extracts and selected coffee chemical compounds against enterobacteria. J. Agric. Food Chem. 2006, 54 (23), 8738-8743.
    • (2006) J. Agric. Food Chem. , vol.54 , Issue.23 , pp. 8738-8743
    • Almeida, A.A.1    Farah, A.2    Silva, D.A.3    Nunan, E.A.4    Gloria, M.B.5
  • 51
    • 0032920143 scopus 로고    scopus 로고
    • Inhibitors of bacterial growth in urine: What is the role of betaines?
    • Chambers, S.T.; Peddie, B.A.; Randall, K.; Lever, M. Inhibitors of bacterial growth in urine: what is the role of betaines? Int. J. Antimicrob. Agents 1999, 11 (3-4), 293-296.
    • (1999) Int. J. Antimicrob. Agents , vol.11 , Issue.3-4 , pp. 293-296
    • Chambers, S.T.1    Peddie, B.A.2    Randall, K.3    Lever, M.4
  • 52
    • 0030338350 scopus 로고    scopus 로고
    • Accumulation of natural and synthetic betaines by a mammalian renal cell line
    • Randall, K.; Lever, M.; Peddie, B.A.; Chambers, S.T. Accumulation of natural and synthetic betaines by a mammalian renal cell line. Biochem. Cell Biol. 1996, 74 (2), 283-287.
    • (1996) Biochem. Cell Biol. , vol.74 , Issue.2 , pp. 283-287
    • Randall, K.1    Lever, M.2    Peddie, B.A.3    Chambers, S.T.4
  • 53
    • 80055084803 scopus 로고    scopus 로고
    • Structure and in vitro antiparasitic activity of constituents of Citropsis articulata root bark
    • Lacroix, D.; Prado, S.; Kamoga, D.; Kasenene, J.; Bodo, B. Structure and in vitro antiparasitic activity of constituents of Citropsis articulata root bark. J. Nat. Prod. 2011, 74 (10), 2286-2289.
    • (2011) J. Nat. Prod. , vol.74 , Issue.10 , pp. 2286-2289
    • Lacroix, D.1    Prado, S.2    Kamoga, D.3    Kasenene, J.4    Bodo, B.5
  • 54
    • 0025911228 scopus 로고
    • Review: Quaternary ammonium compounds in the biosphere-an example of a versatile adaptive strategy
    • Anthoni, U.; Christophersen, C.; Hougaard, L.; Nielsen, P.H. Review: Quaternary ammonium compounds in the biosphere-an example of a versatile adaptive strategy. Comp. Biochem. Physiol. 1991, 99B (1), 1-18.
    • (1991) Comp. Biochem. Physiol. , vol.99 B , Issue.1 , pp. 1-18
    • Anthoni, U.1    Christophersen, C.2    Hougaard, L.3    Nielsen, P.H.4
  • 56
    • 0018771888 scopus 로고
    • Chemical characterization of a hormone that promotes cell arrest in g2 in complex tissues
    • Evans, L.S.; Almeida, M.S.; Lynn, D.G.; Nakanishi, K. Chemical characterization of a hormone that promotes cell arrest in g2 in complex tissues. Science 1979, 203 (4385), 1122-1123.
    • (1979) Science , vol.203 , Issue.4385 , pp. 1122-1123
    • Evans, L.S.1    Almeida, M.S.2    Lynn, D.G.3    Nakanishi, K.4
  • 57
  • 58
    • 2142857218 scopus 로고    scopus 로고
    • Determination of trigonelline by HPLC and study on its pharmacokinetics
    • in Chinese
    • Zhao, H.Q.; Qu, Y.; Wang, X.Y.; Lu, X.Y.; Zhang, X.H.; Hattori, M. Determination of trigonelline by HPLC and study on its pharmacokinetics. Yao Xue Xue Bao 2003, 38 (4), 279-282 (in Chinese).
    • (2003) Yao Xue Xue Bao , vol.38 , Issue.4 , pp. 279-282
    • Zhao, H.Q.1    Qu, Y.2    Wang, X.Y.3    Lu, X.Y.4    Zhang, X.H.5    Hattori, M.6
  • 59
    • 33646455586 scopus 로고    scopus 로고
    • HPLC-MSn analysis of trigonelline and its metabolites in rat urine
    • in Chinese
    • Chen, Y.; Shen, S.L.; Chen, H.X.; Pan, J.; Han, F.M. HPLC-MSn analysis of trigonelline and its metabolites in rat urine. Yao Xue Xue Bao 2006, 41 (3), 216-220 (in Chinese).
    • (2006) Yao Xue Xue Bao , vol.41 , Issue.3 , pp. 216-220
    • Chen, Y.1    Shen, S.L.2    Chen, H.X.3    Pan, J.4    Han, F.M.5
  • 60
    • 0034467938 scopus 로고    scopus 로고
    • Absorption of trigonelline from the small intestine of the specific pathogen-free (SPF) and germ-free (GF) rats in vivo
    • Yuyama, S. Absorption of trigonelline from the small intestine of the specific pathogen-free (SPF) and germ-free (GF) rats in vivo. Adv. Exp. Med. Biol. 1999, 467, 723-727.
    • (1999) Adv. Exp. Med. Biol. , vol.467 , pp. 723-727
    • Yuyama, S.1
  • 61
    • 84863766851 scopus 로고    scopus 로고
    • Studying on interaction between trigonelline and humen serum albumin by fluorescence quenching method
    • in Chinese
    • Wu, W.; Zhao, Y.; Cao, Y.; Han, F.; Chen, Y. Studying on interaction between trigonelline and humen serum albumin by fluorescence quenching method. Acta Chin. Med. Pharm. 2010, 38 (6), 57-59 (in Chinese).
    • (2010) Acta Chin. Med. Pharm. , vol.38 , Issue.6 , pp. 57-59
    • Wu, W.1    Zhao, Y.2    Cao, Y.3    Han, F.4    Chen, Y.5
  • 62
    • 0030333754 scopus 로고    scopus 로고
    • 1-methyl-2-pyridone-5-carboxylic acid and the fate of remaining of trigonelline
    • 1-methyl-2- pyridone-5-carboxylic acid and the fate of remaining of trigonelline. Adv. Exp. Med. Biol. 1996, 398, 599-603.
    • (1996) Adv. Exp. Med. Biol. , vol.398 , pp. 599-603
    • Yuyama, S.1    Kawano, Y.2
  • 63
    • 0025949162 scopus 로고
    • 1-methyl-2-pyridone-5-carboxylic acid and related compounds in human subjects after oral administration of nicotinic acid, trigonelline and N1-methyl-2-pyridone-5-carboxylic acid
    • 1-methyl-2-pyridone- 5-carboxylic acid and related compounds in human subjects after oral administration of nicotinic acid, trigonelline and N1-methyl-2-pyridone-5- carboxylic acid. Adv. Exp. Med. Biol. 1991, 294, 475-479.
    • (1991) Adv. Exp. Med. Biol. , vol.294 , pp. 475-479
    • Yuyama, S.1    Suzuki, T.2
  • 64
    • 0023554942 scopus 로고
    • Effect of dietary N'-methylnicotinamide or trigonelline on the growth and niacin metabolism in weanling rats
    • Shibata, K.; Taguchi, H. Effect of dietary N'-methylnicotinamide or trigonelline on the growth and niacin metabolism in weanling rats. Vitamins 1991, 61 (10), 493-499.
    • (1991) Vitamins , vol.61 , Issue.10 , pp. 493-499
    • Shibata, K.1    Taguchi, H.2
  • 65
    • 85041184686 scopus 로고
    • Preliminary studies of the toxicity of locoweed extracts
    • Faulkner, K.K.; Smith, J. Preliminary studies of the toxicity of locoweed extracts. Proc. Oklahoma Acad. Sci. 1950, 31, 48-50.
    • (1950) Proc. Oklahoma Acad. Sci. , vol.31 , pp. 48-50
    • Faulkner, K.K.1    Smith, J.2
  • 66
    • 0026796053 scopus 로고
    • Cholinomimetic compound distinct from caffeine contained in coffee. II: Muscarinic actions
    • Tse, S.Y. Cholinomimetic compound distinct from caffeine contained in coffee. II: Muscarinic actions. J. Pharm. Sci. 1992, 81 (5), 449-452.
    • (1992) J. Pharm. Sci. , vol.81 , Issue.5 , pp. 449-452
    • Tse, S.Y.1
  • 67
    • 0030752248 scopus 로고    scopus 로고
    • Trigonelline, a naturally occurring constituent of green coffee beans behind the mutagenic activity of roasted coffee?
    • Wu, X.; Skog, K.; Jagerstad, M. Trigonelline, a naturally occurring constituent of green coffee beans behind the mutagenic activity of roasted coffee? Mutat. Res. 1997, 391 (3), 171-177.
    • (1997) Mutat. Res. , vol.391 , Issue.3 , pp. 171-177
    • Wu, X.1    Skog, K.2    Jagerstad, M.3


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