Accumulation of natural and synthetic betaines by a mammalian renal cell line

Biochemistry and Cell Biology

Volumn 74, Issue 2, 1996, Pages 283-287

  Randall, K ^a  

^a CANTERBURY HEALTH LABORATORIES   (New Zealand)

Author keywords

Betaine accumulation; Betaine analogues; MDCK cells; Osmolytes

Indexed keywords

ANTIINFECTIVE AGENT; BETAINE; BETAINE PLASMA MEMBRANE TRANSPORT PROTEINS; CARNITINE; CARRIER PROTEIN; CATION; DRUG DERIVATIVE; HYPERTONIC SOLUTION; PROLINE;

ANIMAL; ARTICLE; BACTERIUM; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DOG; DRUG DESIGN; EPITHELIUM; INTRACELLULAR FLUID; KIDNEY MEDULLA; METABOLISM; OSMOTIC PRESSURE; SPECIES DIFFERENCE; SYNTHESIS;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA; BETAINE; CARNITINE; CARRIER PROTEINS; CATIONS; CELL LINE; DOGS; DRUG DESIGN; EPITHELIUM; HYPERTONIC SOLUTIONS; INTRACELLULAR FLUID; KIDNEY MEDULLA; MOLECULAR STRUCTURE; OSMOTIC PRESSURE; PROLINE; SPECIES SPECIFICITY;

EID: 0030338350     PISSN: 08298211     EISSN: None     Source Type: Journal    
DOI: 10.1139/o96-030     Document Type: Article

References (4)

1. Abdel-Ghany, Y.S., Ihnat, M.A., Miller, D.D., Kunin, C.M., and Tong, H.M. 1993. Structure-activity relationship of glycine betaine analogs on osmotolerance of enteric bacteria. J. Med. Chem. 36: 784-789.
2. Bagnasco, S., Balaban, R.S., Fales, H., Yang, Y.-M., and Burg, M. 1986. Predominantly osmotically active organic solutes in rat and rabbit renal medullas. J. Biol. Chem. 261: 5872-5877.
3. Chambers, S.T., and Kunin, C.M. 1985. The osmoprotective properties of urine for bacteria: the protective effect of betaine and human urine against low pH and high concentrations of electrolytes, sugars and urea. J. Infect. Dis. 152: 1308-1316.
4. Chambers, S.T., and Kunin, C.M. 1987. Isolation of glycine betaine and proline betaine from human urine. Assessment of their role as osmoprotective agents for bacteria and the kidney. J. Clin. Invest. 79: 731-737.