메뉴 건너뛰기




Volumn 27, Issue 3, 2013, Pages 279-287

Experimental diabetes treated with trigonelline: Effect on β cell and pancreatic oxidative parameters

Author keywords

Antioxidant; Diabetes; Insulin; Oxidative stress; Pancreas; Trigonelline

Indexed keywords

CHOLESTEROL; GLIBENCLAMIDE; GLUCOSE; GLUTATHIONE; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; MALONALDEHYDE; NITRIC OXIDE; STREPTOZOCIN; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; TRIGONELLINE;

EID: 84877801646     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2011.01022.x     Document Type: Article
Times cited : (117)

References (46)
  • 1
    • 57249098943 scopus 로고    scopus 로고
    • The barrier of hypoglycemia in diabetes
    • Cryer P.E.The barrier of hypoglycemia in diabetes. Diabetes (2008) 57 3169-3176.
    • (2008) Diabetes , vol.57 , pp. 3169-3176
    • Cryer, P.E.1
  • 2
    • 77952558121 scopus 로고    scopus 로고
    • Quercitrin, a bioflavonoid improves glucose homeostasis in streptozotocin-induced diabetic tissues by altering glycolytic and gluconeogenic enzymes
    • Babujanarthanam R., Kavitha P., Pandian M.R.Quercitrin, a bioflavonoid improves glucose homeostasis in streptozotocin-induced diabetic tissues by altering glycolytic and gluconeogenic enzymes. Fundam. Clin. Pharmacol. (2010) 24 357-364.
    • (2010) Fundam. Clin. Pharmacol. , vol.24 , pp. 357-364
    • Babujanarthanam, R.1    Kavitha, P.2    Pandian, M.R.3
  • 3
    • 68749101167 scopus 로고    scopus 로고
    • Syzygium cumini inhibits adenosine deaminase activity and reduces glucose levels in hyperglycemic patients
    • Bopp A., De Bona K.S., Belle L.P., Moresco R.N., Moretto M.B.Syzygium cumini inhibits adenosine deaminase activity and reduces glucose levels in hyperglycemic patients. Fundam. Clin. Pharmacol. (2009) 23 501-507.
    • (2009) Fundam. Clin. Pharmacol. , vol.23 , pp. 501-507
    • Bopp, A.1    De Bona, K.S.2    Belle, L.P.3    Moresco, R.N.4    Moretto, M.B.5
  • 4
    • 40849085405 scopus 로고    scopus 로고
    • Medicinal plants and the treatment of diabetes in Senegal: survey with patients
    • Dieye A.M., Sarr A., Diop S.N. et al.Medicinal plants and the treatment of diabetes in Senegal: survey with patients. Fundam. Clin. Pharmacol. (2008) 22 211-216.
    • (2008) Fundam. Clin. Pharmacol. , vol.22 , pp. 211-216
    • Dieye, A.M.1    Sarr, A.2    Diop, S.N.3
  • 5
    • 77949905065 scopus 로고    scopus 로고
    • Biochemical evaluation of the protective effect of Aegle marmelos (L.), Corr. leaf extract on tissue antioxidant defense system and histological changes of pancreatic beta-cells in streptozotocin-induced diabetic rats
    • Narendhirakannan R.T., Subramanian S.Biochemical evaluation of the protective effect of Aegle marmelos (L.), Corr. leaf extract on tissue antioxidant defense system and histological changes of pancreatic beta-cells in streptozotocin-induced diabetic rats. Drug Chem. Toxicol. (2010) 33 120-130.
    • (2010) Drug Chem. Toxicol. , vol.33 , pp. 120-130
    • Narendhirakannan, R.T.1    Subramanian, S.2
  • 6
    • 0036804710 scopus 로고    scopus 로고
    • Free radicals, antioxidants, and nutrition
    • Fang Y.Z., Yang S., Wu G.Free radicals, antioxidants, and nutrition. Nutrition (2002) 18 872-879.
    • (2002) Nutrition , vol.18 , pp. 872-879
    • Fang, Y.Z.1    Yang, S.2    Wu, G.3
  • 7
    • 26844564082 scopus 로고    scopus 로고
    • Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice
    • Johansen J.S., Harris A.K., Rychly D.J., Ergul A.Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice. Cardiovasc. Diabetol. (2005) 4 5.
    • (2005) Cardiovasc. Diabetol. , vol.4 , pp. 5
    • Johansen, J.S.1    Harris, A.K.2    Rychly, D.J.3    Ergul, A.4
  • 8
    • 62849129058 scopus 로고    scopus 로고
    • Evaluation of DNA damage and metabolic syndrome parameters in diabetic rabbits supplemented with antioxidants
    • Jain N., Naseem I., Ahmad J.Evaluation of DNA damage and metabolic syndrome parameters in diabetic rabbits supplemented with antioxidants. Fundam. Clin. Pharmacol. (2009) 23 197-205.
    • (2009) Fundam. Clin. Pharmacol. , vol.23 , pp. 197-205
    • Jain, N.1    Naseem, I.2    Ahmad, J.3
  • 9
    • 78349297565 scopus 로고    scopus 로고
    • Oxidative stress and diabetic complications
    • Giacco F., Brownlee M.Oxidative stress and diabetic complications. Circ. Res. (2010) 107 1058-1070.
    • (2010) Circ. Res. , vol.107 , pp. 1058-1070
    • Giacco, F.1    Brownlee, M.2
  • 10
    • 78049375986 scopus 로고    scopus 로고
    • Effects of antioxidants on postprandial oxidative stress and endothelial dysfunction in subjects with impaired glucose tolerance and type 2 diabetes
    • Neri S., Calvagno S., Mauceri B. et al.Effects of antioxidants on postprandial oxidative stress and endothelial dysfunction in subjects with impaired glucose tolerance and type 2 diabetes. Eur. J. Nutr. (2010) 49 409-416.
    • (2010) Eur. J. Nutr. , vol.49 , pp. 409-416
    • Neri, S.1    Calvagno, S.2    Mauceri, B.3
  • 11
    • 26844548140 scopus 로고    scopus 로고
    • State Administration of Traditional Chinese Medicine "Chinese Materia Medica" Editorial Board. . Shanghai Science and Technology Press, Shanghai
    • State Administration of Traditional Chinese Medicine "Chinese Materia Medica" Editorial Board. Chinese Materia Medica (II). Shanghai Science and Technology Press, Shanghai, 1999, pp. 748-749.
    • (1999) Chinese Materia Medica (II) , pp. 748-749
  • 12
    • 84877824843 scopus 로고
    • Jiangsu New Medical College compiled. . Shanghai People's Publishing House, Shanghai
    • Jiangsu New Medical College compiled. The second volume of Dictionary of Chinese Medicine. Shanghai People's Publishing House, Shanghai, 1977, pp. 2370-2371.
    • (1977) The second volume of Dictionary of Chinese Medicine , pp. 2370-2371
  • 13
    • 0002329777 scopus 로고
    • Studies on the isolation and effect of orally active hypoglycemic principle from the seeds of fenugreek (Trigonella foenum graecum)
    • Moorthy R., Prabhu K., Murthy P.Studies on the isolation and effect of orally active hypoglycemic principle from the seeds of fenugreek (Trigonella foenum graecum). Diabetes Bull. (1989) 9 69-72.
    • (1989) Diabetes Bull. , vol.9 , pp. 69-72
    • Moorthy, R.1    Prabhu, K.2    Murthy, P.3
  • 14
    • 0014208934 scopus 로고
    • Hypoglycaemic effect of trigonelline
    • Mishkinsky J., Joseph B., Sulman F.G.Hypoglycaemic effect of trigonelline. Lancet (1967) 2 1311-1312.
    • (1967) Lancet , vol.2 , pp. 1311-1312
    • Mishkinsky, J.1    Joseph, B.2    Sulman, F.G.3
  • 15
    • 66549126196 scopus 로고    scopus 로고
    • Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance
    • van Dijk A.E., Olthof M.R., Meeuse J.C., Seebus E., Heine R.J., van Dam R.M.Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance. Diabetes Care (2009) 32 1023-1025.
    • (2009) Diabetes Care , vol.32 , pp. 1023-1025
    • van Dijk, A.E.1    Olthof, M.R.2    Meeuse, J.C.3    Seebus, E.4    Heine, R.J.5    van Dam, R.M.6
  • 16
    • 79551642386 scopus 로고    scopus 로고
    • Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on incretin hormones
    • Olthof M.R., van Dijk A.E., Deacon C.F., Heine R.J., van Dam R.M.Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on incretin hormones. Nutr. Metab. (Lond) (2011) 8 10.
    • (2011) Nutr. Metab. (Lond) , vol.8 , pp. 10
    • Olthof, M.R.1    van Dijk, A.E.2    Deacon, C.F.3    Heine, R.J.4    van Dam, R.M.5
  • 17
    • 78649836179 scopus 로고    scopus 로고
    • Antioxidant effectiveness of coffee extracts and selected constituents in cell-free systems and human colon cell lines
    • Bakuradze T., Lang R., Hofmann T. et al.Antioxidant effectiveness of coffee extracts and selected constituents in cell-free systems and human colon cell lines. Mol. Nutr. Food Res. (2010) 54 1734-1743.
    • (2010) Mol. Nutr. Food Res. , vol.54 , pp. 1734-1743
    • Bakuradze, T.1    Lang, R.2    Hofmann, T.3
  • 18
    • 77955624213 scopus 로고    scopus 로고
    • Anti-diabetic effect of trigonelline and nicotinic acid, on KK-A(y) mice
    • Yoshinari O., Igarashi K.Anti-diabetic effect of trigonelline and nicotinic acid, on KK-A(y) mice. Curr. Med. Chem. (2010) 17 2196-2202.
    • (2010) Curr. Med. Chem. , vol.17 , pp. 2196-2202
    • Yoshinari, O.1    Igarashi, K.2
  • 19
    • 67049159773 scopus 로고    scopus 로고
    • Anti-diabetic effects of pumpkin and its components, trigonelline and nicotinic acid, on Goto-Kakizaki rats
    • Yoshinari O., Sato H., Igarashi K.Anti-diabetic effects of pumpkin and its components, trigonelline and nicotinic acid, on Goto-Kakizaki rats. Biosci. Biotechnol. Biochem. (2009) 73 1033-1041.
    • (2009) Biosci. Biotechnol. Biochem. , vol.73 , pp. 1033-1041
    • Yoshinari, O.1    Sato, H.2    Igarashi, K.3
  • 20
    • 45749144363 scopus 로고    scopus 로고
    • Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats
    • Zhou J.Y., Zhou S.W., Zhang K.B. et al.Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats. Biol. Pharm. Bull. (2008) 31 1169-1176.
    • (2008) Biol. Pharm. Bull. , vol.31 , pp. 1169-1176
    • Zhou, J.Y.1    Zhou, S.W.2    Zhang, K.B.3
  • 21
    • 79952362196 scopus 로고    scopus 로고
    • Protective effect of berberine on antioxidant enzymes and positive transcription elongation factor b expression in diabetic rat liver
    • Zhou J.Y., Zhou S.W.Protective effect of berberine on antioxidant enzymes and positive transcription elongation factor b expression in diabetic rat liver. Fitoterapia (2011) 82 184-189.
    • (2011) Fitoterapia , vol.82 , pp. 184-189
    • Zhou, J.Y.1    Zhou, S.W.2
  • 22
    • 1542580384 scopus 로고    scopus 로고
    • Effects of tumor necrosis factor, endothelin and nitric oxide on hyperdynamic circulation of rats with acute and chronic portal hypertension
    • Wang J.J., Gao G.W., Gao R.Z., Liu C.A., Ding X., Yao Z.X.Effects of tumor necrosis factor, endothelin and nitric oxide on hyperdynamic circulation of rats with acute and chronic portal hypertension. World J. Gastroenterol. (2004) 10 689-693.
    • (2004) World J. Gastroenterol. , vol.10 , pp. 689-693
    • Wang, J.J.1    Gao, G.W.2    Gao, R.Z.3    Liu, C.A.4    Ding, X.5    Yao, Z.X.6
  • 23
    • 60949108484 scopus 로고    scopus 로고
    • Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats
    • Zhou J., Zhou S., Tang J. et al.Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats. Eur. J. Pharmacol. (2009) 606 262-268.
    • (2009) Eur. J. Pharmacol. , vol.606 , pp. 262-268
    • Zhou, J.1    Zhou, S.2    Tang, J.3
  • 24
    • 78249285581 scopus 로고    scopus 로고
    • Anti-hyperglycemic compound (GII) from fenugreek (Trigonella foenum-graecum Linn.) seeds, its purification and effect in diabetes mellitus
    • Moorthy R., Prabhu K.M., Murthy P.S.Anti-hyperglycemic compound (GII) from fenugreek (Trigonella foenum-graecum Linn.) seeds, its purification and effect in diabetes mellitus. Indian J. Exp. Biol. (2010) 48 1111-1118.
    • (2010) Indian J. Exp. Biol. , vol.48 , pp. 1111-1118
    • Moorthy, R.1    Prabhu, K.M.2    Murthy, P.S.3
  • 25
    • 75649086459 scopus 로고    scopus 로고
    • Effect of long- and short-term treatments with pravastatin on diabetes mellitus and pancreatic fibrosis in the Otsuka-Long-Evans-Tokushima fatty rat
    • Otani M., Yamamoto M., Harada M., Otsuki M.Effect of long- and short-term treatments with pravastatin on diabetes mellitus and pancreatic fibrosis in the Otsuka-Long-Evans-Tokushima fatty rat. Br. J. Pharmacol. (2010) 159 462-473.
    • (2010) Br. J. Pharmacol. , vol.159 , pp. 462-473
    • Otani, M.1    Yamamoto, M.2    Harada, M.3    Otsuki, M.4
  • 26
    • 0033770540 scopus 로고    scopus 로고
    • Life and death of the pancreatic beta cells
    • Bonner-Weir S.Life and death of the pancreatic beta cells. Trends. Endocrinol. Metab. (2000) 11 375-378.
    • (2000) Trends. Endocrinol. Metab. , vol.11 , pp. 375-378
    • Bonner-Weir, S.1
  • 27
    • 34447340935 scopus 로고    scopus 로고
    • TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis
    • Cauchi S., El Achhab Y., Choquet H. et al.TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis. J. Mol. Med. (Berl) (2007) 85 777-782.
    • (2007) J. Mol. Med. (Berl) , vol.85 , pp. 777-782
    • Cauchi, S.1    El Achhab, Y.2    Choquet, H.3
  • 28
    • 36849011549 scopus 로고    scopus 로고
    • Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies
    • Grarup N., Rose C.S., Andersson E.A. et al.Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10, 705 Danish subjects: validation and extension of genome-wide association studies. Diabetes (2007) 56 3105-3111.
    • (2007) Diabetes , vol.56 , pp. 3105-3111
    • Grarup, N.1    Rose, C.S.2    Andersson, E.A.3
  • 29
    • 38749108893 scopus 로고    scopus 로고
    • Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas
    • Xu X., D'Hoker J., Stange G. et al.Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell (2008) 132 197-207.
    • (2008) Cell , vol.132 , pp. 197-207
    • Xu, X.1    D'Hoker, J.2    Stange, G.3
  • 30
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor Y., Brown J., Martinez O.I., Melton D.A.Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature (2004) 429 41-46.
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 31
    • 33644845569 scopus 로고    scopus 로고
    • Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance
    • Kaneto H., Nakatani Y., Kawamori D. et al.Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance. Int. J. Biochem. Cell Biol. (2006) 38 782-793.
    • (2006) Int. J. Biochem. Cell Biol. , vol.38 , pp. 782-793
    • Kaneto, H.1    Nakatani, Y.2    Kawamori, D.3
  • 32
    • 0029984682 scopus 로고    scopus 로고
    • Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
    • Lenzen S., Drinkgern J., Tiedge M.Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic. Biol. Med. (1996) 20 463-466.
    • (1996) Free Radic. Biol. Med. , vol.20 , pp. 463-466
    • Lenzen, S.1    Drinkgern, J.2    Tiedge, M.3
  • 33
    • 0030689041 scopus 로고    scopus 로고
    • Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells
    • Tiedge M., Lortz S., Drinkgern J., Lenzen S.Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes (1997) 46 1733-1742.
    • (1997) Diabetes , vol.46 , pp. 1733-1742
    • Tiedge, M.1    Lortz, S.2    Drinkgern, J.3    Lenzen, S.4
  • 34
    • 33747828219 scopus 로고    scopus 로고
    • Role of oxidative stress in development of cardiovascular complications in diabetes mellitus
    • Haidara M.A., Yassin H.Z., Rateb M., Ammar H., Zorkani M.A.Role of oxidative stress in development of cardiovascular complications in diabetes mellitus. Curr. Vasc. Pharmacol. (2006) 4 215-227.
    • (2006) Curr. Vasc. Pharmacol. , vol.4 , pp. 215-227
    • Haidara, M.A.1    Yassin, H.Z.2    Rateb, M.3    Ammar, H.4    Zorkani, M.A.5
  • 35
    • 77249130189 scopus 로고    scopus 로고
    • Protective effect of quercetin against intracerebral streptozotocin induced reduction in cerebral blood flow and impairment of memory in mice
    • Tota S., Awasthi H., Kamat P.K., Nath C., Hanif K.Protective effect of quercetin against intracerebral streptozotocin induced reduction in cerebral blood flow and impairment of memory in mice. Behav. Brain Res. (2010) 209 73-79.
    • (2010) Behav. Brain Res. , vol.209 , pp. 73-79
    • Tota, S.1    Awasthi, H.2    Kamat, P.K.3    Nath, C.4    Hanif, K.5
  • 36
    • 36649026948 scopus 로고    scopus 로고
    • Dietary supplementation with vitamin E ameliorates cardiac failure in type I diabetic cardiomyopathy by suppressing myocardial generation of 8-iso-prostaglandin F2alpha and oxidized glutathione
    • Hamblin M., Smith H.M., Hill M.F.Dietary supplementation with vitamin E ameliorates cardiac failure in type I diabetic cardiomyopathy by suppressing myocardial generation of 8-iso-prostaglandin F2alpha and oxidized glutathione. J. Card. Fail. (2007) 13 884-892.
    • (2007) J. Card. Fail. , vol.13 , pp. 884-892
    • Hamblin, M.1    Smith, H.M.2    Hill, M.F.3
  • 38
    • 77955828684 scopus 로고    scopus 로고
    • Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice
    • Feng Y., Huang S.L., Dou W. et al.Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice. Br. J. Pharmacol. (2010) 161 113-126.
    • (2010) Br. J. Pharmacol. , vol.161 , pp. 113-126
    • Feng, Y.1    Huang, S.L.2    Dou, W.3
  • 39
    • 0035411656 scopus 로고    scopus 로고
    • Total antioxidant status in non-insulin-dependent diabetes mellitus patients in Ghana
    • Dosoo D.K., Rana S.V., Offe-Amoyaw K., Tete-Donkor D., Maddy S.Q.Total antioxidant status in non-insulin-dependent diabetes mellitus patients in Ghana. West Afr. J. Med. (2001) 20 184-186.
    • (2001) West Afr. J. Med. , vol.20 , pp. 184-186
    • Dosoo, D.K.1    Rana, S.V.2    Offe-Amoyaw, K.3    Tete-Donkor, D.4    Maddy, S.Q.5
  • 40
    • 0034682916 scopus 로고    scopus 로고
    • Lipid peroxidation, antioxidants and cardiovascular disease: how should we move forward?
    • Halliwell B.Lipid peroxidation, antioxidants and cardiovascular disease: how should we move forward?Cardiovasc. Res. (2000) 47 410-418.
    • (2000) Cardiovasc. Res. , vol.47 , pp. 410-418
    • Halliwell, B.1
  • 41
    • 0034044814 scopus 로고    scopus 로고
    • The role of nitric oxide in the development of streptozotocin-induced diabetes mellitus: experimental and clinical implications
    • Haluzik M., Nedvidkova J.The role of nitric oxide in the development of streptozotocin-induced diabetes mellitus: experimental and clinical implications. Physiol. Res. (2000) 49(Suppl 1) S37-S42.
    • (2000) Physiol. Res. , vol.49 , Issue.SUPPL 1
    • Haluzik, M.1    Nedvidkova, J.2
  • 42
    • 54949144344 scopus 로고    scopus 로고
    • Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes
    • Stadler K., Bonini M.G., Dallas S. et al.Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes. Free Radic. Biol. Med. (2008) 45 866-874.
    • (2008) Free Radic. Biol. Med. , vol.45 , pp. 866-874
    • Stadler, K.1    Bonini, M.G.2    Dallas, S.3
  • 43
    • 0027300736 scopus 로고
    • Lipid peroxidation: its mechanism, measurement, and significance
    • discussion 724S-725S.
    • Halliwell B., Chirico S.Lipid peroxidation: its mechanism, measurement, and significance. Am. J. Clin. Nutr. (1993) 57 715S-724S; discussion 724S-725S.
    • (1993) Am. J. Clin. Nutr. , vol.57
    • Halliwell, B.1    Chirico, S.2
  • 44
    • 1542376929 scopus 로고    scopus 로고
    • Glutathione metabolism and its implications for health
    • Wu G., Fang Y.Z., Yang S., Lupton J.R., Turner N.D.Glutathione metabolism and its implications for health. J. Nutr. (2004) 134 489-492.
    • (2004) J. Nutr. , vol.134 , pp. 489-492
    • Wu, G.1    Fang, Y.Z.2    Yang, S.3    Lupton, J.R.4    Turner, N.D.5
  • 45
    • 77952575012 scopus 로고    scopus 로고
    • Antioxidant drugs for treating beta-cell oxidative stress in type 2 diabetes: glucose-centric versus insulin-centric therapy
    • Robertson R.P.Antioxidant drugs for treating beta-cell oxidative stress in type 2 diabetes: glucose-centric versus insulin-centric therapy. Discov. Med. (2010) 9 132-137.
    • (2010) Discov. Med. , vol.9 , pp. 132-137
    • Robertson, R.P.1
  • 46
    • 5644248079 scopus 로고    scopus 로고
    • Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes
    • Robertson R.P.Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes. J. Biol. Chem. (2004) 279 42351-42354.
    • (2004) J. Biol. Chem. , vol.279 , pp. 42351-42354
    • Robertson, R.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.