RGD peptides induce apoptosis by direct caspase-3 activation

Nature

Volumn 397, Issue 6719, 1999, Pages 534-539

  Buckley, Christopher D ^a   Pilling, Darrell ^a   Henriquez, Nick V ^a,b   Parsonage, Greg ^a   Threifall, Katy ^a   Scheel Toellner, Dagmar ^a   Simmons, David L ^b   Akbarf, Arne N ^c   Lord, Janet M ^a   Salmon, Mike ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; SYNTHETIC PEPTIDE;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; CELL CULTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

AMINO ACID SEQUENCE; APOPTOSIS; CASPASE 3; CASPASES; CELL LINE; ENZYME ACTIVATION; ENZYME PRECURSORS; HUMANS; INTEGRINS; JURKAT CELLS; LYMPHOCYTES; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PROTEIN PROCESSING, POST-TRANSLATIONAL; TUMOR CELLS, CULTURED;

MINK CELL FOCUS-FORMING VIRUS; STAPHYLOCOCCUS PHAGE 3A;

EID: 0033545294     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/17409     Document Type: Article

References (30)

1. Ruoslahti, E. RGD and other recognition sequences for integrins. Annu. Rev. Cell Dev. Biol. 12, 697-715 (1996).
2. Meredith, J. E. & Schwartz, M. A. Integrins, adhesion and apoptosis. Trends Cell Biol. 7, 146-150 (1997).
3. Werb, Z. ECM and cell surface proteolysis: regulating cellular ecology. Cell 91, 439-442 (1997).
4. Pasqualini, R., Koivunen, E. & Ruoslahti, E. A peptide isolated from phage display libraries is a structural and functional mimic of an RGD-binding site on integrins. J. Cell Biol. 130, 1189-1196 (1995).
5. Nicholson, D. W. et al. Identification and inhibition of the ICE/ced-3 protease necessary for mammalian apoptosis. Nature 376, 37-43 (1995).
6. Du, X. P. et al. Ligands activate integrin αIIbβ3 (platelet gpIIb-IIIa). Cell 65, 409-416 (1991).
7. Humphries, M. J., Olden, K. & Yamada, K. M. A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma-cells. Science 233, 467-470 (1986).
8. Ferguson, T. A., Mizutani, H. & Kupper, T. S. Two integrin-binding peptides abrogate T cell-mediated immune-responses in vivo. Proc. Natl Acad. Sci. USA 88, 8072-8076 (1991).
9. Brooks, P. C. et al. Integrin αvβ3 antagonists promote tumor-regression by inducing apoptosis of angiogenic blood-vessels. Cell 79, 1157-1164 (1994).
10. Salmon, M. et al. Inhibition of T cell apoptosis in the rheumatoid synovium. J. Clin. Invest. 99, 439-446 (1997).
11. 2+ -enhanced, RGD-dependent adhesion technique for isolation of adult rat type II alveolar epithelial cells for immediate functional studies. Am. J. Resp. Cell Mol. Biol. 10, 347-354 (1994).
12. Yamada, K. M. & Miyamoto, S. Integrin transmembrane signaling and cytoskeletal control. Curr. Opin. Cell Biol. 7, 681-689 (1995).
13. Jacobson, M. D. Programmed cell death: a missing link is found. Trends Cell Biol. 7, 467-469 (1997).
14. Salvesen, G. S. & Dixit, V. M. Caspases: intracellular signaling by proteolysis. Cell 91, 443-446 (1997).
15. Thornberry, N. A. & Lazebnik, Y. Caspases: enemies within. Science 281, 1312-1316 (1998).
16. Henkart, P. A. ICE family proteases - mediators of all apoptotic cell death? Immunity 4, 195-201 (1996).
17. Martin, D. A., Siegel, R. M., Zheng, I., X. & Lenardo, M. J. Membrane oligomerization and cleavage activates the caspase-8 (FLICE/mach α 1) death signal. J. Biol. Chem. 273, 4345-4349 (1998).
18. MacCorkle, R. A., Freeman, K. W. & Spencer, D. M. Synthetic activation of caspases: artificial death switches. Proc. Nalt Acad. Sci. USA 95, 3655-3660 (1998).
19. Yang, X. L., Chang, H. Y. & Baltimore, D. Essential role of ced-4 oligomerization in ced-3 activation and apoptosis. Science 281, 1335-1357 (1998).
20. Pan, G. H., O'Rourke, K. & Dixit, V. M. Caspase-9, Bcl-xL, and APAF-1 form a ternary complex. J. Biol. Chem. 273, 5841-5845 (1998).
21. Janicke, R. U., Sprengart, M. L., Wati, M. R. & Porter, A. G. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J. Biol. Chem. 273, 9357-9360 (1998).
22. Frisch, S. M. & Francis, H. Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124, 619-626 (1994).
23. McGill, G., Shimamura, A., Bates, R. C., Savage, R. E. & Fisher, D. E. Loss of matrix adhesion triggers rapid transformation-selective apoptosis in fibroblasts. J. Cell Biol. 138, 901-911 (1997).
24. Hayman, E. G., Pierschbacher, M. D. & Ruoslahti, E. Detachment of cells from culture substrate by soluble fibronectin peptides. J. Cell Biol. 100, 1948-1954 (1985).
25. Boucaut, J. C. et al. Biologically-active synthetic peptides as probes of embryonic-development - a competitive peptide inhibitor of fibronectin function inhibits gastrulation in amphibian embryos and neural crest cell-migration in avian embryos. J. Cell Biol. 99, 1822-1830 (1984).
26. Dsouza, S. E., Ginsberg, M. H. & Plow, E. F. Arginyl-glycyl-aspartic acid (RGD) - a cell-adhesion motif. Trends Biochem. Sci. 16, 246-250 (1991).
27. Zou, H., Henzel, W. J., Liu, X. S., Lutschg, A. & Wang, X. D. APAF-1, a human protein homologous to C-elegans ced-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90, 405-413 (1997).
28. Chinnaiyan, A. M., O'Rourke, K., Lane, B. R. & Dixit, V. M. Interaction of ced-4 with ced-3 and ced-9: a molecular framework for cell death. Science 275, 1122-1126 (1997).
29. Li, C. J., Friedman, D. J., Wang, C. I., Metelev, V. & Pardee, A. B. Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science 268, 429-431 (1995).
30. Hu, Y. M., Benedict, M. A., Wu, D. Y., Inohara, N. & Nunez, G. Bcl-xl. interacts with APAF-1 and inhibits APAF-1-dependent caspase-9 activation. Proc. Natl Acad. Sci. USA 95, 4386-4391 (1998).