Chemoselective pre-conjugate radiohalogenation of unprotected mono- and multimeric peptides via oxime formation

Radiochimica Acta

Volumn 92, Issue 4-6, 2004, Pages 317-327

  Poethko, Thorsten ^a   Schottelius, Margret ^a   Thumshirn, Georgette ^b   Herz, Michael ^a   Haubner, Roland ^a   Henriksen, Gjermund ^a   Kessler, Horst ^b   Schwaiger, Markus ^a   Wester, Hans Jürgen ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Chemoselective labeling; Fluorine 18; Peptide labeling; PET; Radiohalogenation

Indexed keywords

4 FORMYL N,N,N TRIMETHYLANILINIUM TRIFLATE; ALDEHYDE; AMINO ACID; AMINOOXYACETIC ACID; ARGINYLGLYCYLASPARTIC ACID; ARGINYLGLYCYLASPARTIC ACID DERIVATIVE; BENZALDEHYDE DERIVATIVE; CYCLOPEPTIDE; DIMER; FLUORINE 18; FLUOROBENZALDEHYDE F 18; FUNCTIONAL GROUP; HALOGEN; LEUCYLGLUTAMYLPHENYLALANINE; MONOMER; N (4 FLUOROBENZYLIDENE) OXIME F 18; OXIME; PEPTIDE; POLYMER; TETRAMER; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BIODISTRIBUTION; BLOOD; CATION EXCHANGE; CHEMICAL SELECTIVITY; CONJUGATE; CONJUGATION; FLUORINATION; HALOGENATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; ISOTOPE LABELING; KIDNEY; LIVER; MELANOMA; MELANOMA M21; MOUSE; NONHUMAN; NUDE MOUSE; PEPTIDE SYNTHESIS; PH; POSITRON EMISSION TOMOGRAPHY; PRECONJUGATE; PRECURSOR; PRODUCT RECOVERY; PROTEIN LABELING; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN STABILITY; PROTEIN STRUCTURE; PURIFICATION; RADIO HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; RADIOCHEMICAL YIELD; RADIOHALOGENATION; RADIOISOTOPE DISTRIBUTION; REACTION OPTIMIZATION; SOLID PHASE SYNTHESIS; STRONG CATION EXCHANGE REVERSE PHASE CARTRIDGE SYSTEM; TISSUE DISTRIBUTION;

EID: 3142710802     PISSN: 00338230     EISSN: None     Source Type: Journal    
DOI: 10.1524/ract.92.4.317.35591     Document Type: Article

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