Tetrazine-trans-cyclooctene ligation for the rapid construction of integrin α vβ 3 targeted PET tracer based on a cyclic RGD peptide

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 17, 2011, Pages 5011-5014

  Selvaraj, Ramajeyam ^a   Liu, Shuanglong ^b   Hassink, Matthew ^a   Huang, Chiun Wei ^b   Yap, Li Peng ^b   Park, Ryan ^b   Fox, Joseph M ^a   Li, Zibo ^b   Conti, Peter S ^b  

^a UNIVERSITY OF DELAWARE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Fluorine 18; Integrin v 3; Positron emission tomography (PET); RGD peptide; Tetrazine trans cyclooctene ligation

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; CYCLOOCTENE F 18; FLUORINE 18; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

ARTICLE; CANCER DIAGNOSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; DRUG STRUCTURE; IN VIVO STUDY; ISOTOPE LABELING; POSITRON EMISSION TOMOGRAPHY;

ANIMALS; CATALYSIS; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOOCTANES; FEMALE; INTEGRIN ALPHAVBETA3; KINETICS; MICE; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; OLIGOPEPTIDES; POSITRON-EMISSION TOMOGRAPHY; RADIOMETRY; TETRAZOLES; TRANSPLANTATION, HETEROLOGOUS;

EID: 80051795989     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.116     Document Type: Article

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