Insulin resistance and cancer risk: An overview of the pathogenetic mechanisms

Experimental Diabetes Research

Volumn 2012, Issue , 2012, Pages

  Arcidiacono, Biagio ^a   Iiritano, Stefania ^a   Nocera, Aurora ^a   Possidente, Katiuscia ^a   Nevolo, Maria T ^a   Ventura, Valeria ^a   Foti, Daniela ^a   Chiefari, Eusebio ^a   Brunetti, Antonio ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ACTIVATING TRANSCRIPTION FACTOR 2; ALPHA TOCOPHEROL; ASCORBIC ACID; ESTRADIOL; GROWTH HORMONE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; INSULIN RECEPTOR; INTERLEUKIN 1; INTERLEUKIN 6; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN C FOS; PROTEIN C JUN; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; QUERCETIN; RETINOL; SELENIUM; SOMATOMEDIN C RECEPTOR; TESTOSTERONE; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR ELK 1; TRANSCRIPTION FACTOR FOXO; TUMOR NECROSIS FACTOR ALPHA; REACTIVE OXYGEN METABOLITE; SEX HORMONE BINDING GLOBULIN; SOMATOMEDIN C; STEROID;

ADIPOCYTE; APOPTOSIS; BILIARY TRACT CANCER; BIOAVAILABILITY; BLADDER CANCER; BODY WEIGHT; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CANCER RISK; CANCER TISSUE; CARCINOGENESIS; CELL CYCLE ARREST; CELL METABOLISM; CELL PROLIFERATION; CELL SIZE; CELL SURVIVAL; CHRONIC DISEASE; COLON CANCER; DNA PROTEIN COMPLEX; DYSLIPIDEMIA; ENDOMETRIUM CANCER; ENZYME ACTIVITY; ESOPHAGUS CANCER; GENE ACTIVATION; GENE EXPRESSION; GLYCOLYSIS; HUMAN; HYPERINSULINEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; KIDNEY CANCER; LIVER CANCER; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHODGKIN LYMPHOMA; OBESITY; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; DNA DAMAGE; FEMALE; GENE EXPRESSION REGULATION; METABOLISM; NEOPLASM; OVARY; PATHOLOGY; PATHOPHYSIOLOGY; RISK;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; DIABETES MELLITUS, TYPE 2; DNA DAMAGE; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR I; MODELS, BIOLOGICAL; NEOPLASMS; OBESITY; OVARY; REACTIVE OXYGEN SPECIES; RISK; SEX HORMONE-BINDING GLOBULIN; STEROIDS;

EID: 84863666187     PISSN: 16875214     EISSN: 16875303     Source Type: Journal    
DOI: 10.1155/2012/789174     Document Type: Review

References (126)

1. Reaven G. M., Role of insulin resistance in human disease Diabetes 1988 37 12 1595 1607 (Pubitemid 19004941)
2. Defronzo R. A., From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus Diabetes 2009 58 4 773 795
3. Rao G., Insulin resistance syndrome American Family Physician 2001 63 6 1159 1163 (Pubitemid 32238877)
4. Mayer E. J., Newman B., Austin M. A., Zhang D., Quesenberry C. P., Edwards K., Selby J. V., Genetic and environmental influences on insulin levels and the insulin resistance syndrome: an analysis of women twins The American Journal of Epidemiology 1996 143 4 323 332 (Pubitemid 26056464)
5. Unger R. H., Reinventing type 2 diabetes: pathogenesis, treatment, and prevention Journal of the American Medical Association 2008 299 10 1185 1187 (Pubitemid 351398434)
6. Semple R. K., Savage D. B., Cochran E. K., Gorden P., O'Rahilly S., Genetic syndromes of severe insulin resistance Endocrine Reviews 2011 32 4 498 514
7. Resnick H. E., Jones K., Ruotolo G., Jain A. K., Henderson J., Lu W., Howard B. V., Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease in nondiabetic American Indians: The Strong Heart Study Diabetes Care 2003 26 3 861 867 (Pubitemid 36929356)
8. Hanson R. L., Imperatore G., Bennett P. H., Knowler W. C., Components of the metabolic syndrome and incidence of type 2 diabetes Diabetes 2002 51 10 3120 3127
9. Cowey S., Hardy R. W., The metabolic syndrome: a high-risk state for cancer? American Journal of Pathology 2006 169 5 1505 1522 (Pubitemid 351181984)
10. Kaaks R., Lukanova A., Energy balance and cancer: the role of insulin and insulin-like growth factor-I Proceedings of the Nutrition Society 2001 60 1 91 106 (Pubitemid 32183103)
11. Pollak M., Insulin and insulin-like growth factor signalling in neoplasia Nature Reviews Cancer 2008 8 12 915 928
12. Frasca F., Pandini G., Scalia P., Sciacca L., Mineo R., Costantino A., Goldfine I. D., Belfiore A., Vigneri R., Insulin receptor isoform A, a newly recognized, high-affinity insulin- like growth factor II receptor in fetal and cancer cells Molecular and Cellular Biology 1999 19 5 3278 3288 (Pubitemid 29193789)
13. Vigneri P., Frasca F., Sciacca L., Pandini G., Vigneri R., Diabetes and cancer Endocrine-Related Cancer 2009 16 4 1103 1123
14. Giovannucci E., Harlan D. M., Archer M. C., Bergenstal R. M., Gapstur S. M., Habel L. A., Pollak M., Regensteiner J. G., Yee D., Diabetes and cancer: a consensus report Diabetes Care 2010 33 7 1674 1685
15. Goldfine I. D., The insulin receptor: molecular biology and transmembrane signaling Endocrine Reviews 1987 8 3 235 255
16. Ullrich A., Bell J. R., Chen E. Y., Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes Nature 1985 313 6005 756 761 (Pubitemid 15130823)
17. White M. F., Kahn C. R., The insulin signaling system The Journal of Biological Chemistry 1994 269 1 1 4 (Pubitemid 24026607)
18. Rosen O. M., Structure and function of insulin receptors Diabetes 1989 38 12 1508 1511 (Pubitemid 20006674)
19. Samani A. A., Yakar S., LeRoith D., Brodt P., The role of the IGF system in cancer growth and metastasis: overview and recent insights Endocrine Reviews 2007 28 1 20 47 (Pubitemid 46220849)
20. Singh S. K., Brito C., Tan Q. W., De Len M., De Len D., Differential expression and signaling activation of insulin receptor isoforms A and B: a link between breast cancer and diabetes? Growth Factors 2011 29 6 278 289
21. Denley A., Wallace J. C., Cosgrove L. J., Forbes B. E., The insulin receptor isoform exon 11- (IR-A) in cancer and other diseases: a review Hormone and Metabolic Research 2003 35 11-12 778 785 (Pubitemid 38058183)
22. Taylor S. I., Deconstructing type 2 diabetes Cell 1999 97 1 9 12 (Pubitemid 29165884)
23. DeFronzo R. A., Simonson D., Ferrannini E., Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus Diabetologia 1982 23 4 313 319 (Pubitemid 12020666)
24. Hollenbeck C. B., Chen Y. D., Reaven G. M., A comparison of the relative effects of obesity and non-insulin-dependent diabetes mellitus on in vivo insulin-stimulated glucose utilization Diabetes 1984 33 7 622 626 (Pubitemid 14087552)
25. Biddinger S. B., Kahn C. R., From mice to men: insights into the insulin resistance syndromes Annual Review of Physiology 2006 68 123 158
26. Foti D., Chiefari E., Fedele M., Iuliano R., Brunetti L., Paonessa F., Manfioletti G., Barbetti F., Brunetti A., Croce C. M., Fusco A., Brunetti A., Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice Nature Medicine 2005 11 7 765 773 (Pubitemid 41021209)
27. Chiefari E., Tanyola S., Paonessa F., Pullinger C. R., Capula C., Iiritano S., Mazza T., Forlin M., Fusco A., Durlach V., Durlach A., Malloy M. J., Kane J. P., Heiner S. W., Filocamo M., Foti D. P., Goldfine I. D., Brunetti A., Functional variants of the HMGA1 gene and type 2 diabetes mellitus Journal of the American Medical Association 2011 305 9 903 912
28. Massoner P., Ladurner-Rennau M., Eder I. E., Klocker H., Insulin-like growth factors and insulin control a multifunctional signalling network of significant importance in cancer British Journal of Cancer 2010 103 10 1479 1484
29. Frasca F., Pandini G., Sciacca L., Pezzino V., Squatrito S., Belfiore A., Vigneri R., The role of insulin receptors and IGF-I receptors in cancer and other diseases Archives of Physiology and Biochemistry 2008 114 1 23 37 (Pubitemid 351998752)
30. Papa V., Pezzino V., Costantino A., Belfiore A., Giuffrida D., Frittitta L., Vannelli G. B., Brand R., Goldfine I. D., Vigneri R., Elevated insulin receptor content in human breast cancer Journal of Clinical Investigation 1990 86 5 1503 1510 (Pubitemid 20372597)
31. Law J. H., Habibi G., Hu K., Masoudi H., Wang M. Y. C., Stratford A. L., Park E., Gee J. M. W., Finlay P., Jones H. E., Nicholson R. I., Carboni J., Gottardis M., Pollak M., Dunn S. E., Phosphorylated insulin-like growth factor-I/insulin receptor is present in all breast cancer subtypes and is related to poor survival Cancer Research 2008 68 24 10238 10246
32. Kalli K. R., Falowo O. I., Bale L. K., Zschunke M. A., Roche P. C., Conover C. A., Functional insulin receptors on human epithelial ovarian carcinoma cells: implications for IGF-II mitogenic signaling Endocrinology 2002 143 9 3259 3267 (Pubitemid 34925700)
33. Cox M. E., Gleave M. E., Zakikhani M., Bell R. H., Piura E., Vickers E., Cunningham M., Larsson O., Fazli L., Pollak M., Insulin receptor expression by human prostate cancers Prostate 2009 69 1 33 40
34. Schiel R., Beltschikow W., Steiner T., Stein G., Diabetes, insulin, and risk of cancer Methods and Findings in Experimental and Clinical Pharmacology 2006 28 3 169 175 (Pubitemid 43938540)
35. Giovannucci E., Michaud D., The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas Gastroenterology 2007 132 6 2208 2225 (Pubitemid 46693749)
36. Osborne C. K., Bolan G., Monaco M. E., Lippman M. E., Hormone responsive human breast cancer in long term tissue culture: effect of insulin Proceedings of the National Academy of Sciences of the United States of America 1976 73 12 4536 4540 (Pubitemid 8013935)
37. Paonessa F., Foti D., Costa V., Chiefari E., Brunetti G., Leone F., Luciano F., Wu F., Lee A. S., Gulletta E., Fusco A., Brunetti A., Activator protein-2 overexpression accounts for increased insulin receptor expression in human breast cancer Cancer Research 2006 66 10 5085 5093 (Pubitemid 43844930)
38. Kolb S., Fritsch R., Saur D., Reichert M., Schmid R. M., Schneider G., HMGA1 controls transcription of insulin receptor to regulate cyclin D1 translation in pancreatic cancer cells Cancer Research 2007 67 10 4679 4686 (Pubitemid 46910173)
39. Foti D. P., Paonessa F., Chiefari E., Brunetti A., New target genes for the peroxisome proliferator-activated receptor- (PPAR) antitumour activity: perspectives from the insulin receptor PPAR Research 2009
40. Tontonoz P., Hu E., Spiegelman B. M., Stimulation of adipogenesis in fibroblasts by PPAR 2, a lipid-activated transcription factor Cell 1994 79 7 1147 1156
41. Mueller E., Sarraf P., Tontonoz P., Evans R. M., Martin K. J., Zhang M., Fletcher C., Singer S., Spiegelman B. M., Terminal differentiation of human breast cancer through PPAR Molecular Cell 1998 1 3 465 470 (Pubitemid 128378895)
42. Costa V., Foti D., Paonessa F., Chiefari E., Palaia L., Brunetti G., Gulletta E., Fusco A., Brunetti A., The insulin receptor: a new anticancer target for peroxisome proliferator-activated receptor- (PPAR ) and thiazolidinedione- PPAR agonists Endocrine-Related Cancer 2008 15 1 325 335 (Pubitemid 351449750)
43. Mamula P. W., McDonald A. R., Brunetti A., Okabayashi Y., Wong K. Y., Maddux B. A., Logsdon C., Goldfine I. D., Regulating insulin-receptor-gene expression by differentiation and hormones Diabetes Care 1990 13 3 288 301 (Pubitemid 20092114)
44. Araki E., Shimada F., Uzawa H., Mori M., Ebina Y., Characterization of the promoter region of the human insulin receptor gene: evidence for promoter activity The Journal of Biological Chemistry 1987 262 33 16186 16191 (Pubitemid 17165209)
45. Seino S., Seino M., Nishi S., Bell G. I., Structure of the human insulin receptor gene and characterization of its promoter Proceedings of the National Academy of Sciences of the United States of America 1989 86 1 114 118 (Pubitemid 19036344)
46. Brunetti A., Foti D., Goldfine I. D., Identification of unique nuclear regulatory proteins for the insulin receptor gene, which appear during myocyte and adipocyte differentiation Journal of Clinical Investigation 1993 92 3 1288 1295 (Pubitemid 23273904)
47. Bustin M., Reeves R., High-mobility-group chromosomal proteins: architectural components that facilitate chromatin function Progress in Nucleic Acid research and Molecular Biology 1996 54 35 100
48. Reeves R., Beckerbauer L., HMGI/Y proteins: flexible regulators of transcription and chromatin structure Biochimica et Biophysica Acta 2001 1519 1-2 13 29 (Pubitemid 32530787)
49. Merika M., Thanos D., Enhanceosomes Current Opinion in Genetics and Development 2001 11 2 205 208 (Pubitemid 32209206)
50. Brunetti A., Manfioletti G., Chiefari E., Goldfine I. D., Foti D., Transcriptional regulation of human insulin receptor gene by the high-mobility group protein HMGI(Y) The FASEB Journal 2001 15 2 492 500 (Pubitemid 32141441)
51. Foti D., Iuliano R., Chiefari E., Brunetti A., A nucleoprotein complex containing Sp1, C/EBP, and HMGI-Y controls human insulin receptor gene transcription Molecular and Cellular Biology 2003 23 8 2720 2732 (Pubitemid 36403073)
52. Osborne C. K., Monaco M. E., Lippman M. E., Kahn C. R., Correlation among insulin binding, degradation, and biological activity in human breast cancer cells in long term tissue culture Cancer Research 1978 38 1 94 102 (Pubitemid 8253520)
53. Milazzo G., Giorgino F., Damante G., Sung C., Stampfer M. R., Vigneri R., Goldfine I. D., Belfiore A., Insulin receptor expression and function in human breast cancer cell lines Cancer Research 1992 52 14 3924 3930
54. Farid N. R., Shi Y., Zou M., Molecular basis of thyroid cancer Endocrine Reviews 1994 15 2 202 232 (Pubitemid 24129183)
55. Jones J. I., Clemmons D. R., Insulin-like growth factors and their binding proteins: biological actions Endocrine Reviews 1995 16 1 3 34
56. Clemmons D. R., Underwood L. E., Nutritional regulation of IGF-I and IGF binding proteins Annual Review of Nutrition 1991 11 393 412 (Pubitemid 21903836)
57. Straus D. S., Nutritional regulation of hormones and growth factors that control mammalian growth The FASEB Journal 1994 8 1 6 12 (Pubitemid 24047405)
58. Thissen J. P., Ketelslegers J. M., Underwood L. E., Nutritional regulation of the insulin-like growth factors Endocrine Reviews 1994 15 1 80 101 (Pubitemid 24058597)
59. Calle E. E., Kaaks R., Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms Nature Reviews Cancer 2004 4 8 579 591 (Pubitemid 39025053)
60. Clemmons D. R., Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer Nature Reviews Drug Discovery 2007 6 10 821 833 (Pubitemid 47500506)
61. Soos M. A., Whittaker J., Lammers R., Ullrich A., Siddle K., Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells The Biochemical Journal 1990 270 2 383 390 (Pubitemid 20273478)
62. Ullrich A., Gray A., Tam A. W., Yang-Feng T., Tsubokawa M., Collins C., Henzel W., Le Bon T., Kathuria S., Chen E., Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity The EMBO Journal 1986 5 10 2503 2512
63. Drakas R., Tu X., Baserga R., Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase Proceedings of the National Academy of Sciences of the United States of America 2004 101 25 9272 9276 (Pubitemid 38812865)
64. Kahn C. R., The Gordon Wilson Lecture. Lessons about the control of glucose homeostasis and the pathogenesis of diabetes from knockout mice Transactions of the American Clinical and Climatological Association 2003 114 125 148
65. Ottensmeyer F. P., Beniac D. R., Luo R. Z.-T., Yip C. C., Mechanism of transmembrane signaling: insulin binding and the insulin receptor Biochemistry 2000 39 40 12103 12112
66. Carvalheira J. B., Zecchin H. G., Saad M. J., Vias de sinalizao da insulina Arquivos Brasileiros de Endocrinologia Metabologia 2002 46 4 419 425
67. Cantley L. C., The phosphoinositide 3-kinase pathway Science 2002 296 5573 1655 1657 (Pubitemid 34579158)
68. Barthel A., Schmoll D., Unterman T. G., FoxO proteins in insulin action and metabolism Trends in Endocrinology and Metabolism 2005 16 4 183 189 (Pubitemid 40603098)
69. Zou Y., Tsai W. B., Cheng C. J., Hsu C., Chung Y. M., Li P. C., Lin S. H., Hu M. C. T., Forkhead box transcription factor FOXO3a suppresses estrogen-dependent breast cancer cell proliferation and tumorigenesis Breast Cancer Research 2008 10 1, article R21
70. Hay N., Sonenberg N., Upstream and downstream of mTOR Genes and Development 2004 18 16 1926 1945 (Pubitemid 39071573)
71. Sarbassov D. D., Ali S. M., Sabatini D. M., Growing roles for the mTOR pathway Current Opinion in Cell Biology 2005 17 6 596 603 (Pubitemid 41540408)
72. Inoki K., Li Y., Zhu T., Wu J., Guan K. L., TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling Nature Cell Biology 2002 4 9 648 657 (Pubitemid 34993700)
73. Osrio-Costa F., Rocha G. Z., Dias M. M., Carvalheira J. B. C., Epidemiological and molecular mechanisms aspects linking obesity and cancer Arquivos Brasileiros de Endocrinologia e Metabologia 2009 53 2 213 226
74. Stambolic V., Suzuki A., de la Pompa J. L., Brothers G. M., Mirtsos C., Sasaki T., Ruland J., Penninger J. M., Siderovski D. P., Mak T. W., Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN Cell 1998 95 1 29 39 (Pubitemid 28458022)
75. Simpson L., Parsons R., PTEN: life as a tumor suppressor Experimental Cell Research 2001 264 1 29 41 (Pubitemid 32989079)
76. Ceresa B. P., Pessin J. E., Insulin regulation of the Ras activation/inactivation cycle Molecular and Cellular Biochemistry 1998 182 1-2 23 29 (Pubitemid 28181645)
77. Brunet A., Roux D., Lenormand P., Dowd S., Keyse S., Pouysségur J., Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry The EMBO Journal 1999 18 3 664 674 (Pubitemid 29057251)
78. Roux P. P., Blenis J., ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions Microbiology and Molecular Biology Reviews 2004 68 2 320 344 (Pubitemid 38756868)
79. Murphy L. O., Blenis J., MAPK signal specificity: the right place at the right time Trends in Biochemical Sciences 2006 31 5 268 275 (Pubitemid 43674354)
80. Ryan P. D., Goss P. E., The emerging role of the insulin-like growth factor pathway as a therapeutic target in cancer Oncologist 2008 13 1 16 24 (Pubitemid 351206693)
81. El-Serag H. B., Hampel H., Javadi F., The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence Clinical Gastroenterology and Hepatology 2006 4 3 369 380 (Pubitemid 43343895)
82. Wang C., Wang X., Gong G., Ben Q., Qiu W., Chen Y., Li G., Wang L., Increased risk of hepatocellular carcinoma in patients with diabetes mellitus: a systematic review and meta-analysis of cohort studies International Journal of Cancer 2011 7 6 1639 1648
83. Friberg E., Orsini N., Mantzoros C. S., Wolk A., Diabetes mellitus and risk of endometrial cancer: a meta-analysis Diabetologia 2007 50 7 1365 1374 (Pubitemid 46879010)
84. Huxley R., Ansary-Moghaddam A., Berrington de Gonzlez A., Barzi F., Woodward M., Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies British Journal of Cancer 2005 92 11 2076 2083 (Pubitemid 40897433)
85. Li D., Tang H., Hassan M. M., Holly E. A., Bracci P. M., Silverman D. T., Diabetes and risk of pancreatic cancer: a pooled analysis of three large case-control studies Cancer Causes and Control 2011 22 2 189 197
86. Ben Q., Xu M., Ning X., Liu J., Hong S., Huang W., Zhang H., Li Z., Diabetes mellitus and risk of pancreatic cancer: a meta-analysis of cohort studies European Journal of Cancer 2011 47 13 1928 1937
87. Larsson S. C., Wolk A., Diabetes mellitus and incidence of kidney cancer: a meta-analysis of cohort studies Diabetologia 2011 54 5 1013 1018
88. Ren H. B., Yu T., Liu C., Li Y. Q., Diabetes mellitus and increased risk of biliary tract cancer: systematic review and meta-analysis Cancer Causes and Control 2011 22 6 837 847
89. Jing W., Jin G., Zhou X., Diabetes mellitus and increased risk of cholangiocarcinoma: a meta-analysis European Journal of Cancer Prevention 2011 21 1 24 31
90. Larsson S. C., Orsini N., Brismar K., Wolk A., Diabetes mellitus and risk of bladder cancer: a meta-analysis Diabetologia 2006 49 12 2819 2823 (Pubitemid 44730282)
91. Larsson S. C., Orsini N., Wolk A., Diabetes mellitus and risk of colorectal cancer: a meta-analysis Journal of the National Cancer Institute 2005 97 22 1679 1687 (Pubitemid 41672234)
92. Yuhara H., Steinmaus C., Cohen S. E., Corley D. A., Tei Y., Buffler P. A., Is diabetes mellitus an independent risk factor for colon cancer and rectal cancer? The American Journal of Gastroenterology 2011 106 11 1911 1921
93. Huang W., Ren H., Ben Q., Cai Q., Zhu W., Li Z., Risk of esophageal cancer in diabetes mellitus: a meta-analysis of observational studies Cancer Causes and Control 2011 18 263 272
94. Mitri J., Castillo J., Pittas A. G., Diabetes and risk of non-hodgkin's lymphoma: a meta-analysis of observational studies Diabetes Care 2008 31 12 2391 2397
95. Chao C., Page J. H., Type 2 diabetes mellitus and risk of non-hodgkin lymphoma: a systematic review and meta-analysis The American Journal of Epidemiology 2008 168 5 471 480
96. Larsson S. C., Mantzoros C. S., Wolk A., Diabetes mellitus and risk of breast cancer: a meta-analysis International Journal of Cancer 2007 121 4 856 862 (Pubitemid 47106217)
97. Kershaw E. E., Flier J. S., Adipose tissue as an endocrine organ Journal of Clinical Endocrinology and Metabolism 2004 89 6 2548 2556 (Pubitemid 38766330)
98. Tilg H., Moschen A. R., Adipocytokines: mediators linking adipose tissue, inflammation and immunity Nature Reviews Immunology 2006 6 10 772 783 (Pubitemid 44453463)
99. Kanda H., Tateya S., Tamori Y., Kotani K., Hiasa K. I., Kitazawa R., Kitazawa S., Miyachi H., Maeda S., Egashira K., Kasuga M., MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity Journal of Clinical Investigation 2006 116 6 1494 1505
100. Vona-Davis L., Rose D. P., Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression Endocrine-Related Cancer 2007 14 2 189 206 (Pubitemid 47242622)
101. Iyengar P., Combs T. P., Shah S. J., Gouon-Evans V., Pollard J. W., Albanese C., Flanagan L., Tenniswood M. P., Guha C., Lisanti M. P., Pestell R. G., Scherer P. E., Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization Oncogene 2003 22 41 6408 6423 (Pubitemid 37281689)
102. Macci A., Madeddu C., Obesity, inflammation, and postmenopausal breast cancer: therapeutic implications The Scientific World Journal 2011 11 2020 2036
103. Fantuzzi G., Adipose tissue, adipokines, and inflammation Journal of Allergy and Clinical Immunology 2005 115 5 911 919
104. Li S., Shin H. J., Ding E. L., van Dam R. M., Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis Journal of the American Medical Association 2009 302 2 179 188
105. Schffler A., Schlmerich J., Buechler C., Mechanisms of disease: adipokines and breast cancerendocrine and paracrine mechanisms that connect adiposity and breast cancer Nature Clinical Practice Endocrinology and Metabolism 2007 3 4 345 354 (Pubitemid 46474652)
106. Pignatelli M., Cocca C., Santos A., Perez-Castillo A., Enhancement of BRCA1 gene expression by the peroxisome proliferator-activated receptor in the MCF-7 breast cancer cell line Oncogene 2003 22 35 5446 5450 (Pubitemid 37072199)
107. Furukawa S., Fujita T., Shimabukuro M., Iwaki M., Yamada Y., Nakajima Y., Nakayama O., Makishima M., Matsuda M., Shimomura I., Increased oxidative stress in obesity and its impact on metabolic syndrome Journal of Clinical Investigation 2004 114 12 1752 1761 (Pubitemid 40385531)
108. Sotgia F., Martinez-Outschoorn U. E., Lisanti M. P., Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention? BMC Medicine 2011 9, article 62
109. Hursting S. D., Berger N. A., Energy balance, host-related factors, and cancer progression Journal of Clinical Oncology 2010 28 26 4058 4065
110. Bubici C., Papa S., Dean K., Franzoso G., Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance Oncogene 2006 25 51 6731 6748 (Pubitemid 44657849)
111. Chiavarina B., Whitaker-Menezes D., Migneco G., Martinez-Outschoorn U. E., Pavlides S., Howell A., Tanowitz H. B., Casimiro M. C., Wang C., Pestell R. G., Grieshaber P., Caro J., Sotgia F., Lisanti M. P., HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: autophagy drives compartment-specific oncogenesis Cell Cycle 2010 9 17 3534 3551
112. Martinez-Outschoorn U. E., Balliet R. M., Rivadeneira D. B., Chiavarina B., Pavlides S., Wang C., Whitaker-Menezes D., Daumer K. M., Lin Z., Witkiewicz A. K., Flomenberg N., Howell A., Pestell R. G., Knudsen E. S., Sotgia F., Lisanti M. P., Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: a new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells Cell Cycle 2010 9 16 3256 3276
113. Tuncman G., Hirosumi J., Solinas G., Chang L., Karin M., Hotamisligil G. S., Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance Proceedings of the National Academy of Sciences of the United States of America 2006 103 28 10741 10746 (Pubitemid 44078046)
114. Curat C. A., Miranville A., Sengens C., Diehl M., Tonus C., Busse R., Bouloumié A., From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes Diabetes 2004 53 5 1285 1292 (Pubitemid 38569015)
115. Aron-Wisnewsky J., Minville C., Tordjman J., Chronic intermittent hypoxia is a major trigger for non-alcoholic fatty liver disease in morbid obese Journal of Hepatology 2012 56 1 225 233
116. Grivennikov S. I., Greten F. R., Karin M., Immunity, inflammation, and cancer Cell 2010 140 6 883 899
117. Hotamisligil G. S., Peraldi P., Budavari A., Ellis R., White M. F., Spiegelman B. M., IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF- -and obesity-induced insulin resistance Science 1996 271 5249 665 668 (Pubitemid 26052915)
118. Hotamisligil G. S., Shargill N. S., Spiegelman B. M., Adipose expression of tumor necrosis factor- : direct role in obesity-linked insulin resistance Science 1993 259 5091 87 91 (Pubitemid 23036092)
119. Yu H., Pardoll D., Jove R., STATs in cancer inflammation and immunity: a leading role for STAT3 Nature Reviews Cancer 2009 9 11 798 809
120. Vozarova B., Weyer C., Hanson K., Tataranni P. A., Bogardus C., Pratley R. E., Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion Obesity Research 2001 9 7 414 417 (Pubitemid 33603868)
121. Gonullu G., Ersoy C., Ersoy A., Evrensel T., Basturk B., Kurt E., Oral B., Gokgoz S., Manavoglu O., Relation between insulin resistance and serum concentrations of IL-6 and TNF- in overweight or obese women with early stage breast cancer Cytokine 2005 31 4 264 269 (Pubitemid 41097362)
122. Khandekar M. J., Cohen P., Spiegelman B. M., Molecular mechanisms of cancer development in obesity Nature Reviews Cancer 2011 11 886 895
123. Zheng L., Dai H., Zhou M., Li M., Singh P., Qiu J., Tsark W., Huang Q., Kernstine K., Zhang X., Lin D., Shen B., Fen1 mutations result in autoimmunity, chronic inflammation and cancers Nature Medicine 2007 13 7 812 819 (Pubitemid 47038189)
124. Vakkila J., Lotze M. T., Inflammation and necrosis promote tumour growth Nature Reviews Immunology 2004 4 8 641 648 (Pubitemid 39025049)
125. Hammes H. P., Martin S., Federlin K., Geisen K., Brownlee M., Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy Proceedings of the National Academy of Sciences of the United States of America 1991 88 24 11555 11558 (Pubitemid 21916080)
126. Giardino I., Edelstein D., Brownlee M., Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes Journal of Clinical Investigation 1994 94 1 110 117