Arctigenin alleviates ER stress via activating AMPK

Acta Pharmacologica Sinica

Volumn 33, Issue 7, 2012, Pages 941-952

  Gu, Yuan ^a   Sun, Xiao Xiao ^a   Ye, Ji Ming ^b   He, Li ^a   Yan, Shou Sheng ^a   Zhang, Hao Hao ^a   Hu, Li Hong ^a   Yuan, Jun Ying ^c   Yu, Qiang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b RMIT UNIVERSITY   (Australia)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

cell death; AMPK; arctigenin; ER stress; eukaryotic translation elongation factor 2 (eEF2); human hepatocellular liver carcinoma cell; mitochondrial respiration; mTOR p70S6K

Indexed keywords

ADENYLATE KINASE; ARCTIGENIN;

ANIMAL CELL; ARCTIUM LAPPA; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; RNA INTERFERENCE; UNFOLDED PROTEIN RESPONSE; WESTERN BLOTTING;

ANIMALS; ARCTIUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FURANS; HEP G2 CELLS; HUMANS; INSULIN-SECRETING CELLS; LIGNANS; MALE; PALMITATES; PROTEIN BIOSYNTHESIS; PROTEIN KINASES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

EID: 84863639626     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.60     Document Type: Article

References (42)

1. Sood R, Porter AC, Ma K, Quilliam LA, Wek RC. Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress. Biochem J 2000; 346: 281-93.
2. Shen J, Chen X, Hendershot L, Prywes R. ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev Cell 2002; 3: 99-111.
3. Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 2001; 107: 881-91.
4. Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 2007; 8: 519-29.
5. Kim I, Xu W, Reed JC. Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov 2008; 7: 1013-30.
6. Eizirik DL, Cardozo AK, Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 2008; 29: 42-61.
7. Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004; 306: 457-61.
8. Laybutt DR, Preston AM, Akerfeldt MC, Kench JG, Busch AK, Biankin AV, et al. Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia 2007; 50: 752-63.
9. Cho MK, Jang YP, Kim YC, Kim SG. Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition. Int Immunopharmacol 2004; 4: 1419-29.
10. Zhao F, Wang L, Liu K. In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L, through inhibition on iNOS pathway. J Ethnopharmacol 2009; 122: 457-62.
11. Chan YS, Cheng LN, Wu JH, Chan E, Kwan YW, Lee SM, et al. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology 2011; 19: 245-54.
12. Cervellati R, Speroni E, Govoni P, Guerra MC, Costa S, Arnold UW, et al. Wulfenia carinthiaca Jacq., antioxidant and pharmacological activities. Z Naturforsch C 2004; 59: 255-62.
13. Charlton JL. Antiviral activity of lignans. J Nat Prod 1998; 61: 1447-51.
14. Awale S, Lu J, Kalauni SK, Kurashima Y, Tezuka Y, Kadota S, et al. Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation. Cancer Res 2006; 66: 1751-7.
15. Sun S, Wang X, Wang C, Nawaz A, Wei W, Li J, et al. Arctigenin suppresses unfolded protein response and sensitizes glucose deprivation-mediated cytotoxicity of cancer cells. Planta Med 2011; 77: 141-5.
16. Kim JY, Hwang JH, Cha MR, Yoon MY, Son ES, Tomida A, et al. Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity. J Cell Physiol 2010; 224: 33-40.
17. Hayashi K, Narutaki K, Nagaoka Y, Hayashi T, Uesato S. Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus. Biol Pharm Bull 2010; 33: 1199-205.
18. Turner N, Li JY, Gosby A, To SW, Cheng Z, Miyoshi H, et al. Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. Diabetes 2008; 57: 1414-8.
19. Bi M, Naczki C, Koritzinsky M, Fels D, Blais J, Hu N, et al. ER stressregulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J 2005; 24: 3470-81.
20. Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, et al. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science 2005; 307: 935-9.
21. Ron D. Translational control in the endoplasmic reticulum stress response. J Clin Invest 2002; 110: 1383-8.
22. Cheng SW, Fryer LG, Carling D, Shepherd PR. Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status. J Biol Chem 2004; 279: 15719-22.
23. Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003; 115: 577-90.
24. Mamane Y, Petroulakis E, LeBacquer O, Sonenberg N. mTOR, translation initiation and cancer. Oncogene 2006; 25: 6416-22.
25. Browne GJ, Finn SG, Proud CG. Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. J Biol Chem 2004; 279: 12220-31.
26. Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG. Regulation of elongation factor 2 kinase by p90 (RSK1) and p70 S6 kinase. EMBO J 2001; 20: 4370-9.
27. Redpath NT, Price NT, Severinov KV, Proud CG. Regulation of elongation factor-2 by multisite phosphorylation. Eur J Biochem 1993; 213: 689-99.
28. Carlson CA, Kim KH. Regulation of hepatic acetyl coenzyme A carboxylase by phosphorylation and dephosphorylation. J Biol Chem 1973; 248: 378-80.
29. Hardie DG. The AMP-activated protein kinase pathway-new players upstream and downstream. J Cell Sci 2004; 117: 5479-87.
30. Hardie DG. Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology 2003; 144: 5179-83.
31. Elouil H, Bensellam M, Guiot Y, Vander Mierde D, Pascal SM, Schuit FC, et al. Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets. Diabetologia 2007; 50: 1442-52.
32. Pick A, Clark J, Kubstrup C, Levisetti M, Pugh W, Bonner-Weir S, et al. Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. Diabetes 1998; 47: 358-64.
33. Bonner-Weir S. Islet growth and development in the adult. J Mol Endocrinol 2000; 24: 297-302.
34. Cnop M. Fatty acids and glucolipotoxicity in the pathogenesis of type 2 diabetes. Biochem Soc Trans 2008; 36: 348-52.
35. Kitamura M. Endoplasmic reticulum stress and unfolded protein response in renal pathophysiology: Janus faces. Am J Physiol Renal Physiol 2008; 295: F323-34.
36. Chan AY, Dyck JR. Activation of AMP-activated protein kinase (AMPK) inhibits protein synthesis: a potential strategy to prevent the development of cardiac hypertrophy. Can J Physiol Pharmacol 2005; 83: 24-8.
37. Terai K, Hiramoto Y, Masaki M, Sugiyama S, Kuroda T, Hori M, et al. AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress. Mol Cell Biol 2005; 25: 9554-75.
38. Musi N, Hirshman MF, Nygren J, Svanfeldt M, Bavenholm P, Rooyackers O, et al. Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes. Diabetes 2002; 51: 2074-81.
39. Kim DS, Jeong SK, Kim HR, Chae SW, Chae HJ. Metformin regulates palmitate-induced apoptosis and ER stress response in HepG2 liver cells. Immunopharmacol Immunotoxicol 2010; 32: 251-7.
40. Hao X, Yao A, Gong J, Zhu W, Li N, Li J. Berberine ameliorates pro-inflammatory cytokine-induced endoplasmic reticulum stress in human intestinal epithelial cells in vitro. Inflammation 2012; 35: 841-9.
41. Wang ZS, Lu FE, Xu LJ, Dong H. Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells. Acta Pharmacol Sin 2010; 31: 578-84.
42. Tang X, Zhuang J, Chen J, Yu L, Hu L, Jiang H, et al. Arctigenin efficiently enhanced sedentary mice treadmill endurance. PLoS One 2011; 6: e24224.