Selective spatiotemporal patterns of glial activation and neuron loss in the sensory thalamocortical pathways of neuronal ceroid lipofuscinosis 8 mice

Neurobiology of Disease

Volumn 47, Issue 3, 2012, Pages 444-457

  Kuronen, Mervi ^a,b   Lehesjoki, Anna Elina ^a,b   Jalanko, Anu ^c   Cooper, Jonathan D ^d   Kopra, Outi ^a,b  

^a FOLKHÄLSAN INSTITUTE OF GENETICS   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Batten disease; Cluster of differentiation 68; Glial fibrillary acidic protein; Gliosis; Lysosomal storage; Neurodegeneration; Stereology; Thalamus

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BRAIN REGION; CELL ACTIVATION; CELL LOSS; DISEASE COURSE; GLIA; INTERNEURON; LATERAL GENICULATE BODY; MICROGLIA; MOUSE; NEURONAL CEROID LIPOFUSCINOSIS; NEUROTRANSMISSION; NONHUMAN; ONSET AGE; PATHOLOGY; PRIMARY SOMATOSENSORY CORTEX; PRIORITY JOURNAL; SOMATOSENSORY SYSTEM; STRIATE CORTEX; TARGET CELL; THALAMOCORTICAL TRACT; THALAMUS POSTERIOR NUCLEUS; THALAMUS VENTRAL NUCLEUS; VISUAL SYSTEM;

AFFERENT PATHWAYS; AGE FACTORS; ANALYSIS OF VARIANCE; ANIMALS; CELL COUNT; DISEASE MODELS, ANIMAL; GLIAL FIBRILLARY ACIDIC PROTEIN; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEUROGLIA; NEURONAL CEROID-LIPOFUSCINOSES; NEURONS; SOMATOSENSORY CORTEX; THALAMUS;

EID: 84863494513     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2012.04.018     Document Type: Article

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