Cln5-deficiency in mice leads to microglial activation, defective myelination and changes in lipid metabolism

Neurobiology of Disease

Volumn 46, Issue 1, 2012, Pages 19-29

  Schmiedt, Mia Lisa ^a,b   Blom, Tea ^a   Blom, Tomas ^c   Kopra, Outi ^c   Wong, Andrew ^d   von Schantz Fant, Carina ^b   Ikonen, Elina ^c   Kuronen, Mervi ^c   Jauhiainen, Matti ^a   Cooper, Jonathan D ^d   Jalanko, Anu ^a,b  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b Institute for Molecular Medicine in Finland (FIMM)   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

ErCln5; Lipid metabolism; Microglia; Myelin; NCL; Neuronal ceroid lipofuscinoses; Oligodendrocytes

Indexed keywords

MESSENGER RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL METABOLISM; CLN5 GENE; CONTROLLED STUDY; DEMYELINATION; EMBRYO; GENE EXPRESSION; GENE LOSS; IN VITRO STUDY; LIPID COMPOSITION; LIPID METABOLISM; LIPID TRANSPORT; MALE; MICROGLIA; MOUSE; MUTATOR GENE; NEURONAL CEROID LIPOFUSCINOSIS; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELLS, CULTURED; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; LIPID METABOLISM; LIPID METABOLISM DISORDERS; MACROPHAGES, PERITONEAL; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; NEURONAL CEROID-LIPOFUSCINOSES; NEURONS;

EID: 84858158434     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2011.12.009     Document Type: Article

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